Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice

Grace G. Hendricks, Lilit Grigoryan, Mary Jane Navarro, Nicholas J. Catanzaro, Miranda L. Hubbard, John M. Powers, Melissa Mattocks, Catherine Treichel, Alexandra C. Walls, Jimin Lee, Daniel Ellis, Jing Yang (John) Wang, Suna Cheng, Marcos C. Miranda, Adian Valdez, Cara W. Chao, Sidney Chan, Christine Men, Max R. Johnson, Samantha K. Zepeda, Sebastian Ols, Harold Hui, Sheng-Yang Wu, Victor Lujan, Hiromi Muramatsu, Paulo J.C. Lin, Molly M.H. Sung, Ying K. Tam, Elizabeth M. Leaf, Norbert Pardi, Ralph S. Baric, Bali Pulendran, David Veesler, Alexandra Schäfer, Neil P. King

Open source

DOI: 10.1126/scitranslmed.adu2085
Published: 2025-10-15
Container: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1126/scitranslmed.adu2085,
  title = {Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice},
  author = {Grace G. Hendricks and Lilit Grigoryan and Mary Jane Navarro and Nicholas J. Catanzaro and Miranda L. Hubbard and John M. Powers and Melissa Mattocks and Catherine Treichel and Alexandra C. Walls and Jimin Lee and Daniel Ellis and Jing Yang (John) Wang and Suna Cheng and Marcos C. Miranda and Adian Valdez and Cara W. Chao and Sidney Chan and Christine Men and Max R. Johnson and Samantha K. Zepeda and Sebastian Ols and Harold Hui and Sheng-Yang Wu and Victor Lujan and Hiromi Muramatsu and Paulo J.C. Lin and Molly M.H. Sung and Ying K. Tam and Elizabeth M. Leaf and Norbert Pardi and Ralph S. Baric and Bali Pulendran and David Veesler and Alexandra Schäfer and Neil P. King},
  year = {2025},
  journal = {Science Translational Medicine},
  doi = {10.1126/scitranslmed.adu2085},
  url = {https://doi.org/10.1126/scitranslmed.adu2085}
}

RIS

TY  - JOUR
TI  - Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
AU  - Grace G. Hendricks
AU  - Lilit Grigoryan
AU  - Mary Jane Navarro
AU  - Nicholas J. Catanzaro
AU  - Miranda L. Hubbard
AU  - John M. Powers
AU  - Melissa Mattocks
AU  - Catherine Treichel
AU  - Alexandra C. Walls
AU  - Jimin Lee
AU  - Daniel Ellis
AU  - Jing Yang (John) Wang
AU  - Suna Cheng
AU  - Marcos C. Miranda
AU  - Adian Valdez
AU  - Cara W. Chao
AU  - Sidney Chan
AU  - Christine Men
AU  - Max R. Johnson
AU  - Samantha K. Zepeda
AU  - Sebastian Ols
AU  - Harold Hui
AU  - Sheng-Yang Wu
AU  - Victor Lujan
AU  - Hiromi Muramatsu
AU  - Paulo J.C. Lin
AU  - Molly M.H. Sung
AU  - Ying K. Tam
AU  - Elizabeth M. Leaf
AU  - Norbert Pardi
AU  - Ralph S. Baric
AU  - Bali Pulendran
AU  - David Veesler
AU  - Alexandra Schäfer
AU  - Neil P. King
PY  - 2025
JO  - Science Translational Medicine
DO  - 10.1126/scitranslmed.adu2085
UR  - https://doi.org/10.1126/scitranslmed.adu2085
ER  -

APA

Hendricks, G. G., Grigoryan, L., Navarro, M. J., Catanzaro, N. J., Hubbard, M. L., Powers, J. M., Mattocks, M., Treichel, C., Walls, A. C., Lee, J., Ellis, D., Wang, J. Y. (., Cheng, S., Miranda, M. C., Valdez, A., Chao, C. W., Chan, S., Men, C., Johnson, M. R., Zepeda, S. K., Ols, S., Hui, H., Wu, S., Lujan, V., Muramatsu, H., Lin, P. J., Sung, M. M., Tam, Y. K., Leaf, E. M., Pardi, N., Baric, R. S., Pulendran, B., Veesler, D., Schäfer, A., & King, N. P. (2025). Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.adu2085

Source records

crossref · retrieved 2026-09-26T23:34:48.610Z