A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates with diverse phenotypic and genotypic resistance mechanisms

Ramya Mahadevan, Estefany Garcia, Rajnikant Sharma, Hongqiang Qiu, Ahmed Elsheikh, Robert Parambi, Cely Saad Abboud, Fernando Pasteran, Maria Soledad Ramirez, Keith S. Kaye, Robert A. Bonomo, Gauri G. Rao

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DOI: 10.1128/aac.00782-25
Published: 2026-02-04
Container: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1128/aac.00782-25,
  title = {A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant
                    <i>Klebsiella pneumoniae</i>
                    isolates with diverse phenotypic and genotypic resistance mechanisms},
  author = {Ramya Mahadevan and Estefany Garcia and Rajnikant Sharma and Hongqiang Qiu and Ahmed Elsheikh and Robert Parambi and Cely Saad Abboud and Fernando Pasteran and Maria Soledad Ramirez and Keith S. Kaye and Robert A. Bonomo and Gauri G. Rao},
  year = {2026},
  journal = {Antimicrobial Agents and Chemotherapy},
  doi = {10.1128/aac.00782-25},
  url = {https://doi.org/10.1128/aac.00782-25}
}

RIS

TY  - JOUR
TI  - A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant
                    <i>Klebsiella pneumoniae</i>
                    isolates with diverse phenotypic and genotypic resistance mechanisms
AU  - Ramya Mahadevan
AU  - Estefany Garcia
AU  - Rajnikant Sharma
AU  - Hongqiang Qiu
AU  - Ahmed Elsheikh
AU  - Robert Parambi
AU  - Cely Saad Abboud
AU  - Fernando Pasteran
AU  - Maria Soledad Ramirez
AU  - Keith S. Kaye
AU  - Robert A. Bonomo
AU  - Gauri G. Rao
PY  - 2026
JO  - Antimicrobial Agents and Chemotherapy
DO  - 10.1128/aac.00782-25
UR  - https://doi.org/10.1128/aac.00782-25
ER  -

APA

Mahadevan, R., Garcia, E., Sharma, R., Qiu, H., Elsheikh, A., Parambi, R., Abboud, C. S., Pasteran, F., Ramirez, M. S., Kaye, K. S., Bonomo, R. A., & Rao, G. G. (2026). A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant <i>Klebsiella pneumoniae</i> isolates with diverse phenotypic and genotypic resistance mechanisms. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00782-25

Source records

crossref · retrieved 2026-09-26T22:53:39.533Z