Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Thilo von Groote, Melanie Meersch, Stefano Romagnoli, Marlies Ostermann, Javier Ripollés-Melchor, Antoine Guillaume Schneider, Wim Vandenberghe, Céline Monard, Silvia De Rosa, Lucia Cattin, Tim Rahmel, Michael Adamzik, Diego Parise, Angel Candela-Toha, Jan Gerrit Haaker, Ulrich Göbel, Alice Bernard, Nuttha Lumlertgul, Paula Fernández-Valdes-Bango, Irene Romero Bhathal, A Suarez-de-la-Rica, Jan Larmann, Gianluca Villa, Savino Spadaro, Hinnerk Wulf, Christian Arndt, Christian Putensen, Raquel García-Álvarez, Timo Brandenburger, Antonio Siniscalchi, Richard Ellerkmann, Florian Espeter, Christian Porschen, Mahan Sadjadi, Khaschayar Saadat-Gilani, Raphael Weiss, Joachim Gerss, John Kellum, Alexander Zarbock

Open source

DOI: 10.1136/bmjopen-2022-070240
Published: 2023-03
Container: BMJ Open
Publisher: BMJ
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1136/bmjopen-2022-070240,
  title = {Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial},
  author = {Thilo von Groote and Melanie Meersch and Stefano Romagnoli and Marlies Ostermann and Javier Ripollés-Melchor and Antoine Guillaume Schneider and Wim Vandenberghe and Céline Monard and Silvia De Rosa and Lucia Cattin and Tim Rahmel and Michael Adamzik and Diego Parise and Angel Candela-Toha and Jan Gerrit Haaker and Ulrich Göbel and Alice Bernard and Nuttha Lumlertgul and Paula Fernández-Valdes-Bango and Irene Romero Bhathal and A Suarez-de-la-Rica and Jan Larmann and Gianluca Villa and Savino Spadaro and Hinnerk Wulf and Christian Arndt and Christian Putensen and Raquel García-Álvarez and Timo Brandenburger and Antonio Siniscalchi and Richard Ellerkmann and Florian Espeter and Christian Porschen and Mahan Sadjadi and Khaschayar Saadat-Gilani and Raphael Weiss and Joachim Gerss and John Kellum and Alexander Zarbock},
  year = {2023},
  journal = {BMJ Open},
  doi = {10.1136/bmjopen-2022-070240},
  url = {https://doi.org/10.1136/bmjopen-2022-070240}
}

RIS

TY  - JOUR
TI  - Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial
AU  - Thilo von Groote
AU  - Melanie Meersch
AU  - Stefano Romagnoli
AU  - Marlies Ostermann
AU  - Javier Ripollés-Melchor
AU  - Antoine Guillaume Schneider
AU  - Wim Vandenberghe
AU  - Céline Monard
AU  - Silvia De Rosa
AU  - Lucia Cattin
AU  - Tim Rahmel
AU  - Michael Adamzik
AU  - Diego Parise
AU  - Angel Candela-Toha
AU  - Jan Gerrit Haaker
AU  - Ulrich Göbel
AU  - Alice Bernard
AU  - Nuttha Lumlertgul
AU  - Paula Fernández-Valdes-Bango
AU  - Irene Romero Bhathal
AU  - A Suarez-de-la-Rica
AU  - Jan Larmann
AU  - Gianluca Villa
AU  - Savino Spadaro
AU  - Hinnerk Wulf
AU  - Christian Arndt
AU  - Christian Putensen
AU  - Raquel García-Álvarez
AU  - Timo Brandenburger
AU  - Antonio Siniscalchi
AU  - Richard Ellerkmann
AU  - Florian Espeter
AU  - Christian Porschen
AU  - Mahan Sadjadi
AU  - Khaschayar Saadat-Gilani
AU  - Raphael Weiss
AU  - Joachim Gerss
AU  - John Kellum
AU  - Alexander Zarbock
PY  - 2023
JO  - BMJ Open
DO  - 10.1136/bmjopen-2022-070240
UR  - https://doi.org/10.1136/bmjopen-2022-070240
ER  -

APA

Groote, T. V., Meersch, M., Romagnoli, S., Ostermann, M., Ripollés-Melchor, J., Schneider, A. G., Vandenberghe, W., Monard, C., Rosa, S. D., Cattin, L., Rahmel, T., Adamzik, M., Parise, D., Candela-Toha, A., Haaker, J. G., Göbel, U., Bernard, A., Lumlertgul, N., Fernández-Valdes-Bango, P., Bhathal, I. R., Suarez-de-la-Rica, A., Larmann, J., Villa, G., Spadaro, S., Wulf, H., Arndt, C., Putensen, C., García-Álvarez, R., Brandenburger, T., Siniscalchi, A., Ellerkmann, R., Espeter, F., Porschen, C., Sadjadi, M., Saadat-Gilani, K., Weiss, R., Gerss, J., Kellum, J., & Zarbock, A. (2023). Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial. BMJ Open. https://doi.org/10.1136/bmjopen-2022-070240

Source records

crossref · retrieved 2026-09-26T05:43:53.004Z