Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind controlled trial

Renuka P Dias, Kristian Brock, Kun Hu, Rajat Gupta, Una Martin, Andrew Peet, Martin Wilson, Patrick Yu-Wai-Man, Benjamin Wright, Susan Mollan, Archana Kulkarni, Isabelle Meunier, Lucinda Billingham, Zsuzsanna Nagy, Heather Rose, Sulev Koks, Malgorzata Zatyka, Dewi Astuti, Tracy Lynch, Karen E Morrison, Darren Barton, Sabrina Cronier, Rebecca Malpass, Ruth Evans, Amandip Malhi, Pooja Takhar, Amy Lamb, Gema Esteban-Bueno, Wojciech Młynarski, Christophe Orssaud, Agathe Roubertie, Victoria Homer, Timothy Barrett

Open source

DOI: 10.1136/bmjopen-2024-091495
Published: 2025-02
Container: BMJ Open
Publisher: BMJ
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1136/bmjopen-2024-091495,
  title = {Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind controlled trial},
  author = {Renuka P Dias and Kristian Brock and Kun Hu and Rajat Gupta and Una Martin and Andrew Peet and Martin Wilson and Patrick Yu-Wai-Man and Benjamin Wright and Susan Mollan and Archana Kulkarni and Isabelle Meunier and Lucinda Billingham and Zsuzsanna Nagy and Heather Rose and Sulev Koks and Malgorzata Zatyka and Dewi Astuti and Tracy Lynch and Karen E Morrison and Darren Barton and Sabrina Cronier and Rebecca Malpass and Ruth Evans and Amandip Malhi and Pooja Takhar and Amy Lamb and Gema Esteban-Bueno and Wojciech Młynarski and Christophe Orssaud and Agathe Roubertie and Victoria Homer and Timothy Barrett},
  year = {2025},
  journal = {BMJ Open},
  doi = {10.1136/bmjopen-2024-091495},
  url = {https://doi.org/10.1136/bmjopen-2024-091495}
}

RIS

TY  - JOUR
TI  - Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind controlled trial
AU  - Renuka P Dias
AU  - Kristian Brock
AU  - Kun Hu
AU  - Rajat Gupta
AU  - Una Martin
AU  - Andrew Peet
AU  - Martin Wilson
AU  - Patrick Yu-Wai-Man
AU  - Benjamin Wright
AU  - Susan Mollan
AU  - Archana Kulkarni
AU  - Isabelle Meunier
AU  - Lucinda Billingham
AU  - Zsuzsanna Nagy
AU  - Heather Rose
AU  - Sulev Koks
AU  - Malgorzata Zatyka
AU  - Dewi Astuti
AU  - Tracy Lynch
AU  - Karen E Morrison
AU  - Darren Barton
AU  - Sabrina Cronier
AU  - Rebecca Malpass
AU  - Ruth Evans
AU  - Amandip Malhi
AU  - Pooja Takhar
AU  - Amy Lamb
AU  - Gema Esteban-Bueno
AU  - Wojciech Młynarski
AU  - Christophe Orssaud
AU  - Agathe Roubertie
AU  - Victoria Homer
AU  - Timothy Barrett
PY  - 2025
JO  - BMJ Open
DO  - 10.1136/bmjopen-2024-091495
UR  - https://doi.org/10.1136/bmjopen-2024-091495
ER  -

APA

Dias, R. P., Brock, K., Hu, K., Gupta, R., Martin, U., Peet, A., Wilson, M., Yu-Wai-Man, P., Wright, B., Mollan, S., Kulkarni, A., Meunier, I., Billingham, L., Nagy, Z., Rose, H., Koks, S., Zatyka, M., Astuti, D., Lynch, T., Morrison, K. E., Barton, D., Cronier, S., Malpass, R., Evans, R., Malhi, A., Takhar, P., Lamb, A., Esteban-Bueno, G., Młynarski, W., Orssaud, C., Roubertie, A., Homer, V., & Barrett, T. (2025). Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind controlled trial. BMJ Open. https://doi.org/10.1136/bmjopen-2024-091495

Source records

crossref · retrieved 2026-09-27T00:42:54.563Z