Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial

Floriane Le Vilain-Abraham, Jean-Michel Halimi, Patrick Rossignol, Maurice Laville, Michel Azizi, Bénédicte Stengel, Valentin Maisons, Agnès Rouzès, Agnès Caille, Bénédicte Sautenet

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DOI: 10.1136/bmjopen-2026-122192
Published: 2026-09
Container: BMJ Open
Publisher: BMJ
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1136/bmjopen-2026-122192,
  title = {Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial},
  author = {Floriane Le Vilain-Abraham and Jean-Michel Halimi and Patrick Rossignol and Maurice Laville and Michel Azizi and Bénédicte Stengel and Valentin Maisons and Agnès Rouzès and Agnès Caille and Bénédicte Sautenet},
  year = {2026},
  journal = {BMJ Open},
  doi = {10.1136/bmjopen-2026-122192},
  url = {https://doi.org/10.1136/bmjopen-2026-122192}
}

RIS

TY  - JOUR
TI  - Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial
AU  - Floriane Le Vilain-Abraham
AU  - Jean-Michel Halimi
AU  - Patrick Rossignol
AU  - Maurice Laville
AU  - Michel Azizi
AU  - Bénédicte Stengel
AU  - Valentin Maisons
AU  - Agnès Rouzès
AU  - Agnès Caille
AU  - Bénédicte Sautenet
PY  - 2026
JO  - BMJ Open
DO  - 10.1136/bmjopen-2026-122192
UR  - https://doi.org/10.1136/bmjopen-2026-122192
ER  -

APA

Vilain-Abraham, F. L., Halimi, J., Rossignol, P., Laville, M., Azizi, M., Stengel, B., Maisons, V., Rouzès, A., Caille, A., & Sautenet, B. (2026). Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial. BMJ Open. https://doi.org/10.1136/bmjopen-2026-122192

Source records

crossref · retrieved 2026-09-25T10:59:13.240Z