Circulating extracellular vesicles carrying PD-1, PD-L1 and CTLA-4 inform resistance to anti-PD-L1-based therapy in HCC.

Gorgulho J, Masood R, Buescher G, Giehren F, Salié H, David D, Pagani F, Kocheise L, Schmidt C, Waldmann M, Shafiq M, Möller K, Bokemeyer C, Renné T, Huber S, Lohse AW, Wege H, Maire CL, Ricklefs F, Lamszus K, Breitwieser K, Saul MJ, Zimpel C, Marquardt J, Scheiner B, Balcar L, Pinter M, de Toni E, Piseddu I, Ben Khaled N, Schulze K, von Felden J

Open source

DOI: 10.1136/gutjnl-2025-337617
Published: 2026 Aug 6
Container: Gut
Publisher: Not recorded
Open access: no

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1136/gutjnl-2025-337617,
  title = {Circulating extracellular vesicles carrying PD-1, PD-L1 and CTLA-4 inform resistance to anti-PD-L1-based therapy in HCC.},
  author = {Gorgulho J and Masood R and Buescher G and Giehren F and Salié H and David D and Pagani F and Kocheise L and Schmidt C and Waldmann M and Shafiq M and Möller K and Bokemeyer C and Renné T and Huber S and Lohse AW and Wege H and Maire CL and Ricklefs F and Lamszus K and Breitwieser K and Saul MJ and Zimpel C and Marquardt J and Scheiner B and Balcar L and Pinter M and de Toni E and Piseddu I and Ben Khaled N and Schulze K and von Felden J},
  year = {2026},
  journal = {Gut},
  doi = {10.1136/gutjnl-2025-337617},
  url = {https://doi.org/10.1136/gutjnl-2025-337617}
}

RIS

TY  - JOUR
TI  - Circulating extracellular vesicles carrying PD-1, PD-L1 and CTLA-4 inform resistance to anti-PD-L1-based therapy in HCC.
AU  - Gorgulho J
AU  - Masood R
AU  - Buescher G
AU  - Giehren F
AU  - Salié H
AU  - David D
AU  - Pagani F
AU  - Kocheise L
AU  - Schmidt C
AU  - Waldmann M
AU  - Shafiq M
AU  - Möller K
AU  - Bokemeyer C
AU  - Renné T
AU  - Huber S
AU  - Lohse AW
AU  - Wege H
AU  - Maire CL
AU  - Ricklefs F
AU  - Lamszus K
AU  - Breitwieser K
AU  - Saul MJ
AU  - Zimpel C
AU  - Marquardt J
AU  - Scheiner B
AU  - Balcar L
AU  - Pinter M
AU  - de Toni E
AU  - Piseddu I
AU  - Ben Khaled N
AU  - Schulze K
AU  - von Felden J
PY  - 2026
JO  - Gut
DO  - 10.1136/gutjnl-2025-337617
UR  - https://doi.org/10.1136/gutjnl-2025-337617
ER  -

APA

J, G., R, M., G, B., F, G., H, S., D, D., F, P., L, K., C, S., M, W., M, S., K, M., C, B., T, R., S, H., AW, L., H, W., CL, M., F, R., K, L., K, B., MJ, S., C, Z., J, M., B, S., L, B., M, P., E, D. T., I, P., N, B. K., K, S., & J, V. F. (2026). Circulating extracellular vesicles carrying PD-1, PD-L1 and CTLA-4 inform resistance to anti-PD-L1-based therapy in HCC.. Gut. https://doi.org/10.1136/gutjnl-2025-337617

Source records

pubmed · retrieved 2026-09-26T01:08:06.266Z
europe-pmc · retrieved 2026-09-26T01:08:06.280Z