MAPK Pathway Mutations Emerge in Mutant IDH1 Inhibitor–Resistant Cholangiocarcinoma and Attenuate the IFN Response

Jinkai Wan, Hatice Duygu Saatcioglu, Haley Ellis, Elia Aguado-Fraile, Qin Xu, Hiroshi Kondo, Robert T. Manguso, Ilaria Gritti, Bryanna L. Norden, Carolina Noble, Ryan B. Corcoran, Sam J. Lubner, Milind Javle, Ghassan K. Abou-Alfa, James M. Cleary, Robin K. Kelley, Mitesh J. Borad, Teresa Macarulla, Do Youn Oh, Scott Daigle, Camelia Gliser, Susan Pandya, Sung Choe, Adriana E. Tron, Nabeel Bardeesy

Open source

DOI: 10.1158/1078-0432.ccr-25-3284
Published: 2025-12-29
Container: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1158/1078-0432.ccr-25-3284,
  title = {MAPK Pathway Mutations Emerge in Mutant IDH1 Inhibitor–Resistant Cholangiocarcinoma and Attenuate the IFN Response},
  author = {Jinkai Wan and Hatice Duygu Saatcioglu and Haley Ellis and Elia Aguado-Fraile and Qin Xu and Hiroshi Kondo and Robert T. Manguso and Ilaria Gritti and Bryanna L. Norden and Carolina Noble and Ryan B. Corcoran and Sam J. Lubner and Milind Javle and Ghassan K. Abou-Alfa and James M. Cleary and Robin K. Kelley and Mitesh J. Borad and Teresa Macarulla and Do Youn Oh and Scott Daigle and Camelia Gliser and Susan Pandya and Sung Choe and Adriana E. Tron and Nabeel Bardeesy},
  year = {2025},
  journal = {Clinical Cancer Research},
  doi = {10.1158/1078-0432.ccr-25-3284},
  url = {https://doi.org/10.1158/1078-0432.ccr-25-3284}
}

RIS

TY  - JOUR
TI  - MAPK Pathway Mutations Emerge in Mutant IDH1 Inhibitor–Resistant Cholangiocarcinoma and Attenuate the IFN Response
AU  - Jinkai Wan
AU  - Hatice Duygu Saatcioglu
AU  - Haley Ellis
AU  - Elia Aguado-Fraile
AU  - Qin Xu
AU  - Hiroshi Kondo
AU  - Robert T. Manguso
AU  - Ilaria Gritti
AU  - Bryanna L. Norden
AU  - Carolina Noble
AU  - Ryan B. Corcoran
AU  - Sam J. Lubner
AU  - Milind Javle
AU  - Ghassan K. Abou-Alfa
AU  - James M. Cleary
AU  - Robin K. Kelley
AU  - Mitesh J. Borad
AU  - Teresa Macarulla
AU  - Do Youn Oh
AU  - Scott Daigle
AU  - Camelia Gliser
AU  - Susan Pandya
AU  - Sung Choe
AU  - Adriana E. Tron
AU  - Nabeel Bardeesy
PY  - 2025
JO  - Clinical Cancer Research
DO  - 10.1158/1078-0432.ccr-25-3284
UR  - https://doi.org/10.1158/1078-0432.ccr-25-3284
ER  -

APA

Wan, J., Saatcioglu, H. D., Ellis, H., Aguado-Fraile, E., Xu, Q., Kondo, H., Manguso, R. T., Gritti, I., Norden, B. L., Noble, C., Corcoran, R. B., Lubner, S. J., Javle, M., Abou-Alfa, G. K., Cleary, J. M., Kelley, R. K., Borad, M. J., Macarulla, T., Oh, D. Y., Daigle, S., Gliser, C., Pandya, S., Choe, S., Tron, A. E., & Bardeesy, N. (2025). MAPK Pathway Mutations Emerge in Mutant IDH1 Inhibitor–Resistant Cholangiocarcinoma and Attenuate the IFN Response. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-25-3284

Source records

crossref · retrieved 2026-09-26T17:18:17.058Z