A Novel CDK12 Inhibitor Induces Homologous Recombination Deficiency to Enhance PARP Inhibitor Efficacy in Uterine Serous Carcinoma

Shunsuke Kawahara, Mana Taki, Junzo Hamanishi, Shunsuke Ebara, Ryusuke Murakami, Kohei Hamada, Koichi Watanabe, Yuko Hosoe, Yuka Mise, Shiro Takamatsu, Taito Miyamoto, Rin Mizuno, Koji Yamanoi, Ken Yamaguchi, Hiroko Yamakawa, Nobuyuki Kakiuchi, Tsukasa Baba, Seishi Ogawa, Daisuke Morishita, Kosuke Yusa, Masaki Mandai

Open source

DOI: 10.1158/1535-7163.mct-25-0954
Published: 2026-03-12
Container: Molecular Cancer Therapeutics
Publisher: American Association for Cancer Research (AACR)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1158/1535-7163.mct-25-0954,
  title = {A Novel CDK12 Inhibitor Induces Homologous Recombination Deficiency to Enhance PARP Inhibitor Efficacy in Uterine Serous Carcinoma},
  author = {Shunsuke Kawahara and Mana Taki and Junzo Hamanishi and Shunsuke Ebara and Ryusuke Murakami and Kohei Hamada and Koichi Watanabe and Yuko Hosoe and Yuka Mise and Shiro Takamatsu and Taito Miyamoto and Rin Mizuno and Koji Yamanoi and Ken Yamaguchi and Hiroko Yamakawa and Nobuyuki Kakiuchi and Tsukasa Baba and Seishi Ogawa and Daisuke Morishita and Kosuke Yusa and Masaki Mandai},
  year = {2026},
  journal = {Molecular Cancer Therapeutics},
  doi = {10.1158/1535-7163.mct-25-0954},
  url = {https://doi.org/10.1158/1535-7163.mct-25-0954}
}

RIS

TY  - JOUR
TI  - A Novel CDK12 Inhibitor Induces Homologous Recombination Deficiency to Enhance PARP Inhibitor Efficacy in Uterine Serous Carcinoma
AU  - Shunsuke Kawahara
AU  - Mana Taki
AU  - Junzo Hamanishi
AU  - Shunsuke Ebara
AU  - Ryusuke Murakami
AU  - Kohei Hamada
AU  - Koichi Watanabe
AU  - Yuko Hosoe
AU  - Yuka Mise
AU  - Shiro Takamatsu
AU  - Taito Miyamoto
AU  - Rin Mizuno
AU  - Koji Yamanoi
AU  - Ken Yamaguchi
AU  - Hiroko Yamakawa
AU  - Nobuyuki Kakiuchi
AU  - Tsukasa Baba
AU  - Seishi Ogawa
AU  - Daisuke Morishita
AU  - Kosuke Yusa
AU  - Masaki Mandai
PY  - 2026
JO  - Molecular Cancer Therapeutics
DO  - 10.1158/1535-7163.mct-25-0954
UR  - https://doi.org/10.1158/1535-7163.mct-25-0954
ER  -

APA

Kawahara, S., Taki, M., Hamanishi, J., Ebara, S., Murakami, R., Hamada, K., Watanabe, K., Hosoe, Y., Mise, Y., Takamatsu, S., Miyamoto, T., Mizuno, R., Yamanoi, K., Yamaguchi, K., Yamakawa, H., Kakiuchi, N., Baba, T., Ogawa, S., Morishita, D., Yusa, K., & Mandai, M. (2026). A Novel CDK12 Inhibitor Induces Homologous Recombination Deficiency to Enhance PARP Inhibitor Efficacy in Uterine Serous Carcinoma. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.mct-25-0954

Source records

crossref · retrieved 2026-09-26T15:25:08.303Z