O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis

Anna Borgenvik, Sean A. Misek, Daniel Christen, Gloria Kyrila, Alexander Zhang, Sarah Reel, Michelle Boisvert, Kelly Y. Cai, Anna Kovarzin, Hongyu Li, Kevin N. Zhou, Elizabeth M. Gonzalez, Sara C. Buch-Larsen, Ivo A. Hendriks, Jesper V. Olsen, Corina Anastasaki, Enquan Xu, Amy Goodale, Lorena Lazo de la Vega, Timothy J. Ragnoni, Zohra Kalani, Nicole S. Persky, Tanaz Abid, Esteban A. Miglietta, Sergey Y. Vakhrushev, Michael Stumpe, Jacquelyn S. Jones, Seth Malinowski, Lobna A. Elsadek, Julie Parikh, Alexandra L. Condurat, Aaron Fultineer, Seung Hyun Choi, Merve Ozdemir, Zachary Eisenbies, Joohee Lee, Dana Novikov, Sher Bahadur, April A. Apfelbaum, Jenna Robinson, Louise M. Clark, Noah Schulman, Gianluca Lopez, Daniela Kocher, Carolina Ortiz-Cordero, Kira Tang, Antonio Maldera, Daniel P. Bondeson, Jason J. Kwon, Mounica Vallurupalli, Hyesung Jeon, Sangita Pal, Sandra Jacobs, Todd R. Golub, William C. Hahn, Frederik De Smet, Romain Sigaud, Eric S. Fischer, Jesse S. Boehm, Jörn Dengjel, Henrik Clausen, Nada Jabado, Till Milde, Anne E. Carpenter, David H. Gutmann, Beth A. Cimini, Keith L. Ligon, Katherine A. Janeway, Michael J. Eck, Brittany C. Parker Kerrigan, David E. Root, David T.W. Jones, Tanaz Sharifnia, Timothy N. Phoenix, Rameen Beroukhim, Hiren J. Joshi, Tilman Brummer, Adnan Halim, Pratiti Bandopadhayay

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DOI: 10.1158/2159-8290.cd-25-1114
Published: 2026-09-09
Container: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1158/2159-8290.cd-25-1114,
title = {O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis},
author = {Anna Borgenvik and Sean A. Misek and Daniel Christen and Gloria Kyrila and Alexander Zhang and Sarah Reel and Michelle Boisvert and Kelly Y. Cai and Anna Kovarzin and Hongyu Li and Kevin N. Zhou and Elizabeth M. Gonzalez and Sara C. Buch-Larsen and Ivo A. Hendriks and Jesper V. Olsen and Corina Anastasaki and Enquan Xu and Amy Goodale and Lorena Lazo de la Vega and Timothy J. Ragnoni and Zohra Kalani and Nicole S. Persky and Tanaz Abid and Esteban A. Miglietta and Sergey Y. Vakhrushev and Michael Stumpe and Jacquelyn S. Jones and Seth Malinowski and Lobna A. Elsadek and Julie Parikh and Alexandra L. Condurat and Aaron Fultineer and Seung Hyun Choi and Merve Ozdemir and Zachary Eisenbies and Joohee Lee and Dana Novikov and Sher Bahadur and April A. Apfelbaum and Jenna Robinson and Louise M. Clark and Noah Schulman and Gianluca Lopez and Daniela Kocher and Carolina Ortiz-Cordero and Kira Tang and Antonio Maldera and Daniel P. Bondeson and Jason J. Kwon and Mounica Vallurupalli and Hyesung Jeon and Sangita Pal and Sandra Jacobs and Todd R. Golub and William C. Hahn and Frederik De Smet and Romain Sigaud and Eric S. Fischer and Jesse S. Boehm and Jörn Dengjel and Henrik Clausen and Nada Jabado and Till Milde and Anne E. Carpenter and David H. Gutmann and Beth A. Cimini and Keith L. Ligon and Katherine A. Janeway and Michael J. Eck and Brittany C. Parker Kerrigan and David E. Root and David T.W. Jones and Tanaz Sharifnia and Timothy N. Phoenix and Rameen Beroukhim and Hiren J. Joshi and Tilman Brummer and Adnan Halim and Pratiti Bandopadhayay},
year = {2026},
journal = {Cancer Discovery},
doi = {10.1158/2159-8290.cd-25-1114},
url = {https://doi.org/10.1158/2159-8290.cd-25-1114}
}

RIS

TY  - JOUR
TI  - O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis
AU  - Anna Borgenvik
AU  - Sean A. Misek
AU  - Daniel Christen
AU  - Gloria Kyrila
AU  - Alexander Zhang
AU  - Sarah Reel
AU  - Michelle Boisvert
AU  - Kelly Y. Cai
AU  - Anna Kovarzin
AU  - Hongyu Li
AU  - Kevin N. Zhou
AU  - Elizabeth M. Gonzalez
AU  - Sara C. Buch-Larsen
AU  - Ivo A. Hendriks
AU  - Jesper V. Olsen
AU  - Corina Anastasaki
AU  - Enquan Xu
AU  - Amy Goodale
AU  - Lorena Lazo de la Vega
AU  - Timothy J. Ragnoni
AU  - Zohra Kalani
AU  - Nicole S. Persky
AU  - Tanaz Abid
AU  - Esteban A. Miglietta
AU  - Sergey Y. Vakhrushev
AU  - Michael Stumpe
AU  - Jacquelyn S. Jones
AU  - Seth Malinowski
AU  - Lobna A. Elsadek
AU  - Julie Parikh
AU  - Alexandra L. Condurat
AU  - Aaron Fultineer
AU  - Seung Hyun Choi
AU  - Merve Ozdemir
AU  - Zachary Eisenbies
AU  - Joohee Lee
AU  - Dana Novikov
AU  - Sher Bahadur
AU  - April A. Apfelbaum
AU  - Jenna Robinson
AU  - Louise M. Clark
AU  - Noah Schulman
AU  - Gianluca Lopez
AU  - Daniela Kocher
AU  - Carolina Ortiz-Cordero
AU  - Kira Tang
AU  - Antonio Maldera
AU  - Daniel P. Bondeson
AU  - Jason J. Kwon
AU  - Mounica Vallurupalli
AU  - Hyesung Jeon
AU  - Sangita Pal
AU  - Sandra Jacobs
AU  - Todd R. Golub
AU  - William C. Hahn
AU  - Frederik De Smet
AU  - Romain Sigaud
AU  - Eric S. Fischer
AU  - Jesse S. Boehm
AU  - Jörn Dengjel
AU  - Henrik Clausen
AU  - Nada Jabado
AU  - Till Milde
AU  - Anne E. Carpenter
AU  - David H. Gutmann
AU  - Beth A. Cimini
AU  - Keith L. Ligon
AU  - Katherine A. Janeway
AU  - Michael J. Eck
AU  - Brittany C. Parker Kerrigan
AU  - David E. Root
AU  - David T.W. Jones
AU  - Tanaz Sharifnia
AU  - Timothy N. Phoenix
AU  - Rameen Beroukhim
AU  - Hiren J. Joshi
AU  - Tilman Brummer
AU  - Adnan Halim
AU  - Pratiti Bandopadhayay
PY  - 2026
JO  - Cancer Discovery
DO  - 10.1158/2159-8290.cd-25-1114
UR  - https://doi.org/10.1158/2159-8290.cd-25-1114
ER  -

APA

Borgenvik, A., Misek, S. A., Christen, D., Kyrila, G., Zhang, A., Reel, S., Boisvert, M., Cai, K. Y., Kovarzin, A., Li, H., Zhou, K. N., Gonzalez, E. M., Buch-Larsen, S. C., Hendriks, I. A., Olsen, J. V., Anastasaki, C., Xu, E., Goodale, A., Vega, L. L. D. L., Ragnoni, T. J., Kalani, Z., Persky, N. S., Abid, T., Miglietta, E. A., Vakhrushev, S. Y., Stumpe, M., Jones, J. S., Malinowski, S., Elsadek, L. A., Parikh, J., Condurat, A. L., Fultineer, A., Choi, S. H., Ozdemir, M., Eisenbies, Z., Lee, J., Novikov, D., Bahadur, S., Apfelbaum, A. A., Robinson, J., Clark, L. M., Schulman, N., Lopez, G., Kocher, D., Ortiz-Cordero, C., Tang, K., Maldera, A., Bondeson, D. P., Kwon, J. J., Vallurupalli, M., Jeon, H., Pal, S., Jacobs, S., Golub, T. R., Hahn, W. C., Smet, F. D., Sigaud, R., Fischer, E. S., Boehm, J. S., Dengjel, J., Clausen, H., Jabado, N., Milde, T., Carpenter, A. E., Gutmann, D. H., Cimini, B. A., Ligon, K. L., Janeway, K. A., Eck, M. J., Kerrigan, B. C. P., Root, D. E., Jones, D. T., Sharifnia, T., Phoenix, T. N., Beroukhim, R., Joshi, H. J., Brummer, T., Halim, A., & Bandopadhayay, P. (2026). O-mannosylation and protein maturation checkpoints represent therapeutic opportunities in BRAF fusion protein oncogenesis. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-25-1114

Source records

crossref · retrieved 2026-09-25T08:08:09.717Z