<i>SPEN</i> Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities

Benedikt Pelzer, Cem Meydan, Isaac M. Spiegel, Ioannis Karagiannidis, Min Xia, Matt Teater, Emma M. Welter, Zowie E. Searcy, Laura K. Hilton, Darko Barisic, Amos Fong, Pengyan Fa, Shenon Sethi, Irem S. Isgor, Jessie J. Fielding, Alireza Karbalayghareh, Colin S. Burdette, Sravya Tumuluru, Sonia M. Debek, Sunjae Lee, Ramon Massoni-Badosa, Ceyda Durmaz, Eralda Salataj, Prasath Pararajalingam, Zhengming Chen, Richard J. Pelzl, Sanket Shah, Martin A. Rivas, Kenneth B. Hoehn, Coraline Mlynarczyk, Hannah M. Isles, Xiang Wang, Ahmet Dogan, Kojo S.J. Elenitoba-Johnson, David W. Scott, Kostiantyn Dreval, Ryan D. Morin, Christina S. Leslie, Rishi Puri, Jacob B. Geri, Christopher R. Chin, Amy Chadburn, Christopher E. Mason, Hans Christian Reinhardt, Montserrat C. Anguera, Wendy Béguelin, Leandro Venturutti, Ari M. Melnick

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DOI: 10.1158/2159-8290.cd-25-1458
Published: 2026-04-21
Container: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1158/2159-8290.cd-25-1458,
  title = {<i>SPEN</i>
                    Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities},
  author = {Benedikt Pelzer and Cem Meydan and Isaac M. Spiegel and Ioannis Karagiannidis and Min Xia and Matt Teater and Emma M. Welter and Zowie E. Searcy and Laura K. Hilton and Darko Barisic and Amos Fong and Pengyan Fa and Shenon Sethi and Irem S. Isgor and Jessie J. Fielding and Alireza Karbalayghareh and Colin S. Burdette and Sravya Tumuluru and Sonia M. Debek and Sunjae Lee and Ramon Massoni-Badosa and Ceyda Durmaz and Eralda Salataj and Prasath Pararajalingam and Zhengming Chen and Richard J. Pelzl and Sanket Shah and Martin A. Rivas and Kenneth B. Hoehn and Coraline Mlynarczyk and Hannah M. Isles and Xiang Wang and Ahmet Dogan and Kojo S.J. Elenitoba-Johnson and David W. Scott and Kostiantyn Dreval and Ryan D. Morin and Christina S. Leslie and Rishi Puri and Jacob B. Geri and Christopher R. Chin and Amy Chadburn and Christopher E. Mason and Hans Christian Reinhardt and Montserrat C. Anguera and Wendy Béguelin and Leandro Venturutti and Ari M. Melnick},
  year = {2026},
  journal = {Cancer Discovery},
  doi = {10.1158/2159-8290.cd-25-1458},
  url = {https://doi.org/10.1158/2159-8290.cd-25-1458}
}

RIS

TY  - JOUR
TI  - <i>SPEN</i>
                    Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities
AU  - Benedikt Pelzer
AU  - Cem Meydan
AU  - Isaac M. Spiegel
AU  - Ioannis Karagiannidis
AU  - Min Xia
AU  - Matt Teater
AU  - Emma M. Welter
AU  - Zowie E. Searcy
AU  - Laura K. Hilton
AU  - Darko Barisic
AU  - Amos Fong
AU  - Pengyan Fa
AU  - Shenon Sethi
AU  - Irem S. Isgor
AU  - Jessie J. Fielding
AU  - Alireza Karbalayghareh
AU  - Colin S. Burdette
AU  - Sravya Tumuluru
AU  - Sonia M. Debek
AU  - Sunjae Lee
AU  - Ramon Massoni-Badosa
AU  - Ceyda Durmaz
AU  - Eralda Salataj
AU  - Prasath Pararajalingam
AU  - Zhengming Chen
AU  - Richard J. Pelzl
AU  - Sanket Shah
AU  - Martin A. Rivas
AU  - Kenneth B. Hoehn
AU  - Coraline Mlynarczyk
AU  - Hannah M. Isles
AU  - Xiang Wang
AU  - Ahmet Dogan
AU  - Kojo S.J. Elenitoba-Johnson
AU  - David W. Scott
AU  - Kostiantyn Dreval
AU  - Ryan D. Morin
AU  - Christina S. Leslie
AU  - Rishi Puri
AU  - Jacob B. Geri
AU  - Christopher R. Chin
AU  - Amy Chadburn
AU  - Christopher E. Mason
AU  - Hans Christian Reinhardt
AU  - Montserrat C. Anguera
AU  - Wendy Béguelin
AU  - Leandro Venturutti
AU  - Ari M. Melnick
PY  - 2026
JO  - Cancer Discovery
DO  - 10.1158/2159-8290.cd-25-1458
UR  - https://doi.org/10.1158/2159-8290.cd-25-1458
ER  -

APA

Pelzer, B., Meydan, C., Spiegel, I. M., Karagiannidis, I., Xia, M., Teater, M., Welter, E. M., Searcy, Z. E., Hilton, L. K., Barisic, D., Fong, A., Fa, P., Sethi, S., Isgor, I. S., Fielding, J. J., Karbalayghareh, A., Burdette, C. S., Tumuluru, S., Debek, S. M., Lee, S., Massoni-Badosa, R., Durmaz, C., Salataj, E., Pararajalingam, P., Chen, Z., Pelzl, R. J., Shah, S., Rivas, M. A., Hoehn, K. B., Mlynarczyk, C., Isles, H. M., Wang, X., Dogan, A., Elenitoba-Johnson, K. S., Scott, D. W., Dreval, K., Morin, R. D., Leslie, C. S., Puri, R., Geri, J. B., Chin, C. R., Chadburn, A., Mason, C. E., Reinhardt, H. C., Anguera, M. C., Béguelin, W., Venturutti, L., & Melnick, A. M. (2026). <i>SPEN</i> Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities. Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-25-1458

Source records

crossref · retrieved 2026-09-26T13:10:51.796Z