Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells

Benjamin A. Brakel, Dillon McKenna, Anish Puri, Muhammad Vaseem. Shaikh, Manoj Singh, Ali Saleh, Abdo-jose Tomajian, Nicholas Mikolajewicz, Marcello Beltrami, Maxwell Topley, Alisha Anand, Petar Miletic, Kevin R. Brown, David Tieu, William Maich, Sabra Salim, Yujin Suk, Minomi Subapanditha, Deena M. A. Gendoo, Chitra Venugopal, Jason Moffat, Sachin Katyal, Chirayu R. Chokshi, Sheila K. Singh

Open source

DOI: 10.1158/2767-9764.crc-26-0150
Published: 2026-09-21
Container: Cancer Research Communications
Publisher: American Association for Cancer Research (AACR)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1158/2767-9764.crc-26-0150,
  title = {Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells},
  author = {Benjamin A. Brakel and Dillon McKenna and Anish Puri and Muhammad Vaseem. Shaikh and Manoj Singh and Ali Saleh and Abdo-jose Tomajian and Nicholas Mikolajewicz and Marcello Beltrami and Maxwell Topley and Alisha Anand and Petar Miletic and Kevin R. Brown and David Tieu and William Maich and Sabra Salim and Yujin Suk and Minomi Subapanditha and Deena M. A. Gendoo and Chitra Venugopal and Jason Moffat and Sachin Katyal and Chirayu R. Chokshi and Sheila K. Singh},
  year = {2026},
  journal = {Cancer Research Communications},
  doi = {10.1158/2767-9764.crc-26-0150},
  url = {https://doi.org/10.1158/2767-9764.crc-26-0150}
}

RIS

TY  - JOUR
TI  - Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells
AU  - Benjamin A. Brakel
AU  - Dillon McKenna
AU  - Anish Puri
AU  - Muhammad Vaseem. Shaikh
AU  - Manoj Singh
AU  - Ali Saleh
AU  - Abdo-jose Tomajian
AU  - Nicholas Mikolajewicz
AU  - Marcello Beltrami
AU  - Maxwell Topley
AU  - Alisha Anand
AU  - Petar Miletic
AU  - Kevin R. Brown
AU  - David Tieu
AU  - William Maich
AU  - Sabra Salim
AU  - Yujin Suk
AU  - Minomi Subapanditha
AU  - Deena M. A. Gendoo
AU  - Chitra Venugopal
AU  - Jason Moffat
AU  - Sachin Katyal
AU  - Chirayu R. Chokshi
AU  - Sheila K. Singh
PY  - 2026
JO  - Cancer Research Communications
DO  - 10.1158/2767-9764.crc-26-0150
UR  - https://doi.org/10.1158/2767-9764.crc-26-0150
ER  -

APA

Brakel, B. A., McKenna, D., Puri, A., Shaikh, M. V., Singh, M., Saleh, A., Tomajian, A., Mikolajewicz, N., Beltrami, M., Topley, M., Anand, A., Miletic, P., Brown, K. R., Tieu, D., Maich, W., Salim, S., Suk, Y., Subapanditha, M., Gendoo, D. M. A., Venugopal, C., Moffat, J., Katyal, S., Chokshi, C. R., & Singh, S. K. (2026). Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells. Cancer Research Communications. https://doi.org/10.1158/2767-9764.crc-26-0150

Source records

crossref · retrieved 2026-09-25T21:29:36.578Z