Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve

Sébastien Thériault, Jacob A. Holdcraft, Dinara Sharipova, Adèle Faucherre, Radoslaw M. Debiec, Gina M. Peloso, Baravan Al-Kassou, Sary Aranki, Elena Ashikhmina Swan, Andrea Ballotta, Michele Bellino, Hanna M. Björck, Anne Sophie Boureau, Peter S. Braund, François Corriveau, François Dagenais, Lasse Folkersen, Amalia Forte, Michael D. Francke, Alessandro Frigiola, Svetlana Gorbatov, Dongchuan Guo, Karam M. Habchi, Mahyar Heydarpour, Eric M. Isselbacher, Chris Jopling, Fabien Laporte, Solena Le Scouarnec, Zhonglin Li, Peter Lichtner, Carlo Maj, Hasanga D. Manikpurage, Christopher P. Nelson, Thy B. Nguyen, Russell A. Norris, Chin Siang Ong, Philippe Pibarot, Tanmoy Roychowdhury, Berardo Sarubbi, Floriane Simonet, Thoralf Sundt, Ida Surakka, Idit Tessler, Cristen J. Willer, Susanne Wittmann, Bo Yang, Igor Berezovets, Stefanie A. Doppler, Martina Dreßen, Katharina Knoll, Thomas Puehler, Heribert Schunkert, Jean-François Avierinos, Malenka M. Bissell, Aidan P. Bolger, Yohan Bossé, Eduardo Bossone, María Brion, Rodolfo Citro, Carlo de Vincentiis, G. Michael Deeb, Alessandro Della Corte, Christian Dina, Ronen Durst, Stephan Ensminger, Per Eriksson, Arturo Evangelista, Anders Franco-Cereceda, Dan Gilon, Betti Giusti, Simon L. Hetherington, Gordon S. Huggins, Markus Krane, Thierry Le Tourneau, Giuseppe Limongelli, Patrick Mathieu, David Messika-Zeitoun, Hector I. Michelena, Dianna Milewicz, Jochen D. Muehlschlegel, David R. Murdock, Georg Nickenig, Stefano Nistri, Markus M. Nöthen, Francesca Pluchinotta, Siddharth K Prakash, Nilesh J. Samani, Jean-Jacques Schott, Tom R. Webb, Stéphane Zaffran, Salim Abdelilah-Seyfried, Kim Eagle, Johannes Schumacher, Teresa Trenkwalder, Simon C. Body

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DOI: 10.1161/circulationaha.125.074752
Published: 2026-04-07
Container: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1161/circulationaha.125.074752,
title = {Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve},
author = {Sébastien Thériault and Jacob A. Holdcraft and Dinara Sharipova and Adèle Faucherre and Radoslaw M. Debiec and Gina M. Peloso and Baravan Al-Kassou and Sary Aranki and Elena Ashikhmina Swan and Andrea Ballotta and Michele Bellino and Hanna M. Björck and Anne Sophie Boureau and Peter S. Braund and François Corriveau and François Dagenais and Lasse Folkersen and Amalia Forte and Michael D. Francke and Alessandro Frigiola and Svetlana Gorbatov and Dongchuan Guo and Karam M. Habchi and Mahyar Heydarpour and Eric M. Isselbacher and Chris Jopling and Fabien Laporte and Solena Le Scouarnec and Zhonglin Li and Peter Lichtner and Carlo Maj and Hasanga D. Manikpurage and Christopher P. Nelson and Thy B. Nguyen and Russell A. Norris and Chin Siang Ong and Philippe Pibarot and Tanmoy Roychowdhury and Berardo Sarubbi and Floriane Simonet and Thoralf Sundt and Ida Surakka and Idit Tessler and Cristen J. Willer and Susanne Wittmann and Bo Yang and Igor Berezovets and Stefanie A. Doppler and Martina Dreßen and Katharina Knoll and Thomas Puehler and Heribert Schunkert and Jean-François Avierinos and Malenka M. Bissell and Aidan P. Bolger and Yohan Bossé and Eduardo Bossone and María Brion and Rodolfo Citro and Carlo de Vincentiis and G. Michael Deeb and Alessandro Della Corte and Christian Dina and Ronen Durst and Stephan Ensminger and Per Eriksson and Arturo Evangelista and Anders Franco-Cereceda and Dan Gilon and Betti Giusti and Simon L. Hetherington and Gordon S. Huggins and Markus Krane and Thierry Le Tourneau and Giuseppe Limongelli and Patrick Mathieu and David Messika-Zeitoun and Hector I. Michelena and Dianna Milewicz and Jochen D. Muehlschlegel and David R. Murdock and Georg Nickenig and Stefano Nistri and Markus M. Nöthen and Francesca Pluchinotta and Siddharth K Prakash and Nilesh J. Samani and Jean-Jacques Schott and Tom R. Webb and Stéphane Zaffran and Salim Abdelilah-Seyfried and Kim Eagle and Johannes Schumacher and Teresa Trenkwalder and Simon C. Body},
year = {2026},
journal = {Circulation},
doi = {10.1161/circulationaha.125.074752},
url = {https://doi.org/10.1161/circulationaha.125.074752}
}

RIS

TY  - JOUR
TI  - Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve
AU  - Sébastien Thériault
AU  - Jacob A. Holdcraft
AU  - Dinara Sharipova
AU  - Adèle Faucherre
AU  - Radoslaw M. Debiec
AU  - Gina M. Peloso
AU  - Baravan Al-Kassou
AU  - Sary Aranki
AU  - Elena Ashikhmina Swan
AU  - Andrea Ballotta
AU  - Michele Bellino
AU  - Hanna M. Björck
AU  - Anne Sophie Boureau
AU  - Peter S. Braund
AU  - François Corriveau
AU  - François Dagenais
AU  - Lasse Folkersen
AU  - Amalia Forte
AU  - Michael D. Francke
AU  - Alessandro Frigiola
AU  - Svetlana Gorbatov
AU  - Dongchuan Guo
AU  - Karam M. Habchi
AU  - Mahyar Heydarpour
AU  - Eric M. Isselbacher
AU  - Chris Jopling
AU  - Fabien Laporte
AU  - Solena Le Scouarnec
AU  - Zhonglin Li
AU  - Peter Lichtner
AU  - Carlo Maj
AU  - Hasanga D. Manikpurage
AU  - Christopher P. Nelson
AU  - Thy B. Nguyen
AU  - Russell A. Norris
AU  - Chin Siang Ong
AU  - Philippe Pibarot
AU  - Tanmoy Roychowdhury
AU  - Berardo Sarubbi
AU  - Floriane Simonet
AU  - Thoralf Sundt
AU  - Ida Surakka
AU  - Idit Tessler
AU  - Cristen J. Willer
AU  - Susanne Wittmann
AU  - Bo Yang
AU  - Igor Berezovets
AU  - Stefanie A. Doppler
AU  - Martina Dreßen
AU  - Katharina Knoll
AU  - Thomas Puehler
AU  - Heribert Schunkert
AU  - Jean-François Avierinos
AU  - Malenka M. Bissell
AU  - Aidan P. Bolger
AU  - Yohan Bossé
AU  - Eduardo Bossone
AU  - María Brion
AU  - Rodolfo Citro
AU  - Carlo de Vincentiis
AU  - G. Michael Deeb
AU  - Alessandro Della Corte
AU  - Christian Dina
AU  - Ronen Durst
AU  - Stephan Ensminger
AU  - Per Eriksson
AU  - Arturo Evangelista
AU  - Anders Franco-Cereceda
AU  - Dan Gilon
AU  - Betti Giusti
AU  - Simon L. Hetherington
AU  - Gordon S. Huggins
AU  - Markus Krane
AU  - Thierry Le Tourneau
AU  - Giuseppe Limongelli
AU  - Patrick Mathieu
AU  - David Messika-Zeitoun
AU  - Hector I. Michelena
AU  - Dianna Milewicz
AU  - Jochen D. Muehlschlegel
AU  - David R. Murdock
AU  - Georg Nickenig
AU  - Stefano Nistri
AU  - Markus M. Nöthen
AU  - Francesca Pluchinotta
AU  - Siddharth K Prakash
AU  - Nilesh J. Samani
AU  - Jean-Jacques Schott
AU  - Tom R. Webb
AU  - Stéphane Zaffran
AU  - Salim Abdelilah-Seyfried
AU  - Kim Eagle
AU  - Johannes Schumacher
AU  - Teresa Trenkwalder
AU  - Simon C. Body
PY  - 2026
JO  - Circulation
DO  - 10.1161/circulationaha.125.074752
UR  - https://doi.org/10.1161/circulationaha.125.074752
ER  -

APA

Thériault, S., Holdcraft, J. A., Sharipova, D., Faucherre, A., Debiec, R. M., Peloso, G. M., Al-Kassou, B., Aranki, S., Swan, E. A., Ballotta, A., Bellino, M., Björck, H. M., Boureau, A. S., Braund, P. S., Corriveau, F., Dagenais, F., Folkersen, L., Forte, A., Francke, M. D., Frigiola, A., Gorbatov, S., Guo, D., Habchi, K. M., Heydarpour, M., Isselbacher, E. M., Jopling, C., Laporte, F., Scouarnec, S. L., Li, Z., Lichtner, P., Maj, C., Manikpurage, H. D., Nelson, C. P., Nguyen, T. B., Norris, R. A., Ong, C. S., Pibarot, P., Roychowdhury, T., Sarubbi, B., Simonet, F., Sundt, T., Surakka, I., Tessler, I., Willer, C. J., Wittmann, S., Yang, B., Berezovets, I., Doppler, S. A., Dreßen, M., Knoll, K., Puehler, T., Schunkert, H., Avierinos, J., Bissell, M. M., Bolger, A. P., Bossé, Y., Bossone, E., Brion, M., Citro, R., Vincentiis, C. D., Deeb, G. M., Corte, A. D., Dina, C., Durst, R., Ensminger, S., Eriksson, P., Evangelista, A., Franco-Cereceda, A., Gilon, D., Giusti, B., Hetherington, S. L., Huggins, G. S., Krane, M., Tourneau, T. L., Limongelli, G., Mathieu, P., Messika-Zeitoun, D., Michelena, H. I., Milewicz, D., Muehlschlegel, J. D., Murdock, D. R., Nickenig, G., Nistri, S., Nöthen, M. M., Pluchinotta, F., Prakash, S. K., Samani, N. J., Schott, J., Webb, T. R., Zaffran, S., Abdelilah-Seyfried, S., Eagle, K., Schumacher, J., Trenkwalder, T., & Body, S. C. (2026). Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. Circulation. https://doi.org/10.1161/circulationaha.125.074752

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crossref · retrieved 2026-09-25T16:27:30.897Z