Oral Relaxin Receptor Agonist AZD5462 in Participants With Chronic Heart Failure: Primary Results From the LUMINARA Trial

James L. Januzzi, Jaya B. Rosenmeier, Patricia Ely Pizzato, Macarena P. Quintana-Hayashi, Lai-Shan Melanie Chan, Petra Johannesson, Chandrali S. Bhattacharya, Daniel Aradi, Jeroen Schaap, Jiri Vesely, Grzegorz Piotrowski, Koichiro Kinugawa, Daniel Pettersen, Joao Lima, Martin Fredriksson, Yana Simova, Nikolay Runev, Bozhidar Krastev, Maria Tzekova, Iskra Bayraktarova, David Horak, Ladislav Busak, Ondrej Toman, Otto Mayer, Søren Vraa, Henrik Wiggers, Zsolt Zilahi, Robert Kirschner, Ebrahim Noori, Sankar Chandra Mondal, Atul Domodar Abhyankar, Nirav Chandulal Bhalani, Jabir Abdullakutty, Mamoru 守 Manita 間仁田, Masatoshi 雅俊 Shimizu 清水, Takatoshi 隆俊 Wakeyama 分山, Masato Ohnishi, Akihiro 明浩 Nakamura 中村, Kuniyoshi 邦剛 Fukai 深井, Susumu 晋 Fujino 藤野, Junjiro 准二郎 Koyama 古山, Yoshisato 剛徳 Shibata 柴田, Tomomi 智三 Koizumi 小泉, Wouter Jansen Klomp, Mieke van den Heuvel, Ewa Mirek Bryniarska, Bartosz Krakowiak, Joanna Szachniewicz, Grzegorz Gajos, Marcin Grabowski, Beata Sokolova, Martin Caprnda, Michal Banik, Hamid Taheri, Hanh Bui, John McGinty, Joshua Todd, Brian Foley, Juan Londono, Mehrdad Ariani, Olakunle Akinboboye, Jose Escalante, Ignacio Velazquez, Joseph Izzo, Kirkwood Adams, Gregory Lewis, Yana Simova, Nikolay Runev, Bozhidar Krastev, Maria Tzekova, Iskra Bayraktarova, David Horak, Ladislav Busak, Ondrej Toman, Otto Mayer, Søren Vraa, Henrik Wiggers, Zsolt Zilahi, Robert Kirschner, Ebrahim Noori, Sankar Chandra Mondal, Atul Domodar Abhyankar, Nirav Chandulal Bhalani, Jabir Abdullakutty, Mamoru 守 Manita 間仁田, Masatoshi 雅俊 Shimizu 清水, Takatoshi 隆俊 Wakeyama 分山, Masato Ohnishi, Akihiro 明浩 Nakamura 中村, Kuniyoshi 邦剛 Fukai 深井, Susumu 晋 Fujino 藤野, Junjiro 准二郎 Koyama 古山, Yoshisato 剛徳 Shibata 柴田, Tomomi 智三 Koizumi 小泉, Wouter Jansen Klomp, Mieke van den Heuvel, Ewa Mirek Bryniarska, Bartosz Krakowiak, Joanna Szachniewicz, Grzegorz Gajos, Marcin Grabowski, Beata Sokolova, Martin Caprnda, Michal Banik, Hamid Taheri, Hanh Bui, John McGinty, Joshua Todd, Brian Foley, Juan Londono, Mehrdad Ariani, Olakunle Akinboboye, Jose Escalante, Ignacio Velazquez, Joseph Izzo, Kirkwood Adams, Gregory Lewis

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DOI: 10.1161/circulationaha.126.082763
Published: 2026-08-30
Container: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Open access: unknown

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BibTeX

@article{allodium:10.1161/circulationaha.126.082763,
  title = {Oral Relaxin Receptor Agonist AZD5462 in Participants With Chronic Heart Failure: Primary Results From the LUMINARA Trial},
  author = {James L. Januzzi and Jaya B. Rosenmeier and Patricia Ely Pizzato and Macarena P. Quintana-Hayashi and Lai-Shan Melanie Chan and Petra Johannesson and Chandrali S. Bhattacharya and Daniel Aradi and Jeroen Schaap and Jiri Vesely and Grzegorz Piotrowski and Koichiro Kinugawa and Daniel Pettersen and Joao Lima and Martin Fredriksson and Yana Simova and Nikolay Runev and Bozhidar Krastev and Maria Tzekova and Iskra Bayraktarova and David Horak and Ladislav Busak and Ondrej Toman and Otto Mayer and Søren Vraa and Henrik Wiggers and Zsolt Zilahi and Robert Kirschner and Ebrahim Noori and Sankar Chandra Mondal and Atul Domodar Abhyankar and Nirav Chandulal Bhalani and Jabir Abdullakutty and Mamoru 守 Manita 間仁田 and Masatoshi 雅俊 Shimizu 清水 and Takatoshi 隆俊 Wakeyama 分山 and Masato Ohnishi and Akihiro 明浩 Nakamura 中村 and Kuniyoshi 邦剛 Fukai 深井 and Susumu 晋 Fujino 藤野 and Junjiro 准二郎 Koyama 古山 and Yoshisato 剛徳 Shibata 柴田 and Tomomi 智三 Koizumi 小泉 and Wouter Jansen Klomp and Mieke van den Heuvel and Ewa Mirek Bryniarska and Bartosz Krakowiak and Joanna Szachniewicz and Grzegorz Gajos and Marcin Grabowski and Beata Sokolova and Martin Caprnda and Michal Banik and Hamid Taheri and Hanh Bui and John McGinty and Joshua Todd and Brian Foley and Juan Londono and Mehrdad Ariani and Olakunle Akinboboye and Jose Escalante and Ignacio Velazquez and Joseph Izzo and Kirkwood Adams and Gregory Lewis and Yana Simova and Nikolay Runev and Bozhidar Krastev and Maria Tzekova and Iskra Bayraktarova and David Horak and Ladislav Busak and Ondrej Toman and Otto Mayer and Søren Vraa and Henrik Wiggers and Zsolt Zilahi and Robert Kirschner and Ebrahim Noori and Sankar Chandra Mondal and Atul Domodar Abhyankar and Nirav Chandulal Bhalani and Jabir Abdullakutty and Mamoru 守 Manita 間仁田 and Masatoshi 雅俊 Shimizu 清水 and Takatoshi 隆俊 Wakeyama 分山 and Masato Ohnishi and Akihiro 明浩 Nakamura 中村 and Kuniyoshi 邦剛 Fukai 深井 and Susumu 晋 Fujino 藤野 and Junjiro 准二郎 Koyama 古山 and Yoshisato 剛徳 Shibata 柴田 and Tomomi 智三 Koizumi 小泉 and Wouter Jansen Klomp and Mieke van den Heuvel and Ewa Mirek Bryniarska and Bartosz Krakowiak and Joanna Szachniewicz and Grzegorz Gajos and Marcin Grabowski and Beata Sokolova and Martin Caprnda and Michal Banik and Hamid Taheri and Hanh Bui and John McGinty and Joshua Todd and Brian Foley and Juan Londono and Mehrdad Ariani and Olakunle Akinboboye and Jose Escalante and Ignacio Velazquez and Joseph Izzo and Kirkwood Adams and Gregory Lewis},
  year = {2026},
  journal = {Circulation},
  doi = {10.1161/circulationaha.126.082763},
  url = {https://doi.org/10.1161/circulationaha.126.082763}
}

RIS

TY  - JOUR
TI  - Oral Relaxin Receptor Agonist AZD5462 in Participants With Chronic Heart Failure: Primary Results From the LUMINARA Trial
AU  - James L. Januzzi
AU  - Jaya B. Rosenmeier
AU  - Patricia Ely Pizzato
AU  - Macarena P. Quintana-Hayashi
AU  - Lai-Shan Melanie Chan
AU  - Petra Johannesson
AU  - Chandrali S. Bhattacharya
AU  - Daniel Aradi
AU  - Jeroen Schaap
AU  - Jiri Vesely
AU  - Grzegorz Piotrowski
AU  - Koichiro Kinugawa
AU  - Daniel Pettersen
AU  - Joao Lima
AU  - Martin Fredriksson
AU  - Yana Simova
AU  - Nikolay Runev
AU  - Bozhidar Krastev
AU  - Maria Tzekova
AU  - Iskra Bayraktarova
AU  - David Horak
AU  - Ladislav Busak
AU  - Ondrej Toman
AU  - Otto Mayer
AU  - Søren Vraa
AU  - Henrik Wiggers
AU  - Zsolt Zilahi
AU  - Robert Kirschner
AU  - Ebrahim Noori
AU  - Sankar Chandra Mondal
AU  - Atul Domodar Abhyankar
AU  - Nirav Chandulal Bhalani
AU  - Jabir Abdullakutty
AU  - Mamoru 守 Manita 間仁田
AU  - Masatoshi 雅俊 Shimizu 清水
AU  - Takatoshi 隆俊 Wakeyama 分山
AU  - Masato Ohnishi
AU  - Akihiro 明浩 Nakamura 中村
AU  - Kuniyoshi 邦剛 Fukai 深井
AU  - Susumu 晋 Fujino 藤野
AU  - Junjiro 准二郎 Koyama 古山
AU  - Yoshisato 剛徳 Shibata 柴田
AU  - Tomomi 智三 Koizumi 小泉
AU  - Wouter Jansen Klomp
AU  - Mieke van den Heuvel
AU  - Ewa Mirek Bryniarska
AU  - Bartosz Krakowiak
AU  - Joanna Szachniewicz
AU  - Grzegorz Gajos
AU  - Marcin Grabowski
AU  - Beata Sokolova
AU  - Martin Caprnda
AU  - Michal Banik
AU  - Hamid Taheri
AU  - Hanh Bui
AU  - John McGinty
AU  - Joshua Todd
AU  - Brian Foley
AU  - Juan Londono
AU  - Mehrdad Ariani
AU  - Olakunle Akinboboye
AU  - Jose Escalante
AU  - Ignacio Velazquez
AU  - Joseph Izzo
AU  - Kirkwood Adams
AU  - Gregory Lewis
AU  - Yana Simova
AU  - Nikolay Runev
AU  - Bozhidar Krastev
AU  - Maria Tzekova
AU  - Iskra Bayraktarova
AU  - David Horak
AU  - Ladislav Busak
AU  - Ondrej Toman
AU  - Otto Mayer
AU  - Søren Vraa
AU  - Henrik Wiggers
AU  - Zsolt Zilahi
AU  - Robert Kirschner
AU  - Ebrahim Noori
AU  - Sankar Chandra Mondal
AU  - Atul Domodar Abhyankar
AU  - Nirav Chandulal Bhalani
AU  - Jabir Abdullakutty
AU  - Mamoru 守 Manita 間仁田
AU  - Masatoshi 雅俊 Shimizu 清水
AU  - Takatoshi 隆俊 Wakeyama 分山
AU  - Masato Ohnishi
AU  - Akihiro 明浩 Nakamura 中村
AU  - Kuniyoshi 邦剛 Fukai 深井
AU  - Susumu 晋 Fujino 藤野
AU  - Junjiro 准二郎 Koyama 古山
AU  - Yoshisato 剛徳 Shibata 柴田
AU  - Tomomi 智三 Koizumi 小泉
AU  - Wouter Jansen Klomp
AU  - Mieke van den Heuvel
AU  - Ewa Mirek Bryniarska
AU  - Bartosz Krakowiak
AU  - Joanna Szachniewicz
AU  - Grzegorz Gajos
AU  - Marcin Grabowski
AU  - Beata Sokolova
AU  - Martin Caprnda
AU  - Michal Banik
AU  - Hamid Taheri
AU  - Hanh Bui
AU  - John McGinty
AU  - Joshua Todd
AU  - Brian Foley
AU  - Juan Londono
AU  - Mehrdad Ariani
AU  - Olakunle Akinboboye
AU  - Jose Escalante
AU  - Ignacio Velazquez
AU  - Joseph Izzo
AU  - Kirkwood Adams
AU  - Gregory Lewis
PY  - 2026
JO  - Circulation
DO  - 10.1161/circulationaha.126.082763
UR  - https://doi.org/10.1161/circulationaha.126.082763
ER  -

APA

Januzzi, J. L., Rosenmeier, J. B., Pizzato, P. E., Quintana-Hayashi, M. P., Chan, L. M., Johannesson, P., Bhattacharya, C. S., Aradi, D., Schaap, J., Vesely, J., Piotrowski, G., Kinugawa, K., Pettersen, D., Lima, J., Fredriksson, M., Simova, Y., Runev, N., Krastev, B., Tzekova, M., Bayraktarova, I., Horak, D., Busak, L., Toman, O., Mayer, O., Vraa, S., Wiggers, H., Zilahi, Z., Kirschner, R., Noori, E., Mondal, S. C., Abhyankar, A. D., Bhalani, N. C., Abdullakutty, J., 間仁田, M. 守. M., 清水, M. 雅. S., 分山, T. 隆. W., Ohnishi, M., 中村, A. 明. N., 深井, K. 邦. F., 藤野, S. 晋. F., 古山, J. 准. K., 柴田, Y. 剛. S., 小泉, T. 智. K., Klomp, W. J., Heuvel, M. V. D., Bryniarska, E. M., Krakowiak, B., Szachniewicz, J., Gajos, G., Grabowski, M., Sokolova, B., Caprnda, M., Banik, M., Taheri, H., Bui, H., McGinty, J., Todd, J., Foley, B., Londono, J., Ariani, M., Akinboboye, O., Escalante, J., Velazquez, I., Izzo, J., Adams, K., Lewis, G., Simova, Y., Runev, N., Krastev, B., Tzekova, M., Bayraktarova, I., Horak, D., Busak, L., Toman, O., Mayer, O., Vraa, S., Wiggers, H., Zilahi, Z., Kirschner, R., Noori, E., Mondal, S. C., Abhyankar, A. D., Bhalani, N. C., Abdullakutty, J., 間仁田, M. 守. M., 清水, M. 雅. S., 分山, T. 隆. W., Ohnishi, M., 中村, A. 明. N., 深井, K. 邦. F., 藤野, S. 晋. F., 古山, J. 准. K., 柴田, Y. 剛. S., 小泉, T. 智. K., Klomp, W. J., Heuvel, M. V. D., Bryniarska, E. M., Krakowiak, B., Szachniewicz, J., Gajos, G., Grabowski, M., Sokolova, B., Caprnda, M., Banik, M., Taheri, H., Bui, H., McGinty, J., Todd, J., Foley, B., Londono, J., Ariani, M., Akinboboye, O., Escalante, J., Velazquez, I., Izzo, J., Adams, K., & Lewis, G. (2026). Oral Relaxin Receptor Agonist AZD5462 in Participants With Chronic Heart Failure: Primary Results From the LUMINARA Trial. Circulation. https://doi.org/10.1161/circulationaha.126.082763

Source records

crossref · retrieved 2026-09-27T03:40:46.329Z