Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients

Caroline Hoffmann, Jan-Timon Werle, Philémon Sirven, Mamy Andrianteranagna, Jocelyn Gal, Wiem Lassoued, Jerzy Klijanienko, Jeremy Mesple, Benjamin Demaille, Abdenour Abbas, Valentine Gauthier, Kyra J.E. Borgman, Isabelle Puisieux, Serena Janho dit Hreich, Olivier Choussy, Gregoire Marret, Sonia Lameiras, Nathalie Badois, Antoine Dubray-Vautrin, Gilles Dolivet, Lionnel Geoffrois, Renaud Leclère, Wail Zeitouni, Noemie Robil, Jane Merlevede, Altynbek Zhubanchaliyev, Maud Kamal, Ivan Bieche, Laure Monard, Clotilde Simon, Delphine Louis, Clint T. Allen, Arun Rajan, James L. Gulley, Maude Guillot-Delost, Christophe Le Tourneau, Hélène Salmon

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DOI: 10.1172/jci198718
Published: 2026-11-02
Container: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1172/jci198718,
  title = {Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients},
  author = {Caroline Hoffmann and Jan-Timon Werle and Philémon Sirven and Mamy Andrianteranagna and Jocelyn Gal and Wiem Lassoued and Jerzy Klijanienko and Jeremy Mesple and Benjamin Demaille and Abdenour Abbas and Valentine Gauthier and Kyra J.E. Borgman and Isabelle Puisieux and Serena Janho dit Hreich and Olivier Choussy and Gregoire Marret and Sonia Lameiras and Nathalie Badois and Antoine Dubray-Vautrin and Gilles Dolivet and Lionnel Geoffrois and Renaud Leclère and Wail Zeitouni and Noemie Robil and Jane Merlevede and Altynbek Zhubanchaliyev and Maud Kamal and Ivan Bieche and Laure Monard and Clotilde Simon and Delphine Louis and Clint T. Allen and Arun Rajan and James L. Gulley and Maude Guillot-Delost and Christophe Le Tourneau and Hélène Salmon},
  year = {2026},
  journal = {Journal of Clinical Investigation},
  doi = {10.1172/jci198718},
  url = {https://doi.org/10.1172/jci198718}
}

RIS

TY  - JOUR
TI  - Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients
AU  - Caroline Hoffmann
AU  - Jan-Timon Werle
AU  - Philémon Sirven
AU  - Mamy Andrianteranagna
AU  - Jocelyn Gal
AU  - Wiem Lassoued
AU  - Jerzy Klijanienko
AU  - Jeremy Mesple
AU  - Benjamin Demaille
AU  - Abdenour Abbas
AU  - Valentine Gauthier
AU  - Kyra J.E. Borgman
AU  - Isabelle Puisieux
AU  - Serena Janho dit Hreich
AU  - Olivier Choussy
AU  - Gregoire Marret
AU  - Sonia Lameiras
AU  - Nathalie Badois
AU  - Antoine Dubray-Vautrin
AU  - Gilles Dolivet
AU  - Lionnel Geoffrois
AU  - Renaud Leclère
AU  - Wail Zeitouni
AU  - Noemie Robil
AU  - Jane Merlevede
AU  - Altynbek Zhubanchaliyev
AU  - Maud Kamal
AU  - Ivan Bieche
AU  - Laure Monard
AU  - Clotilde Simon
AU  - Delphine Louis
AU  - Clint T. Allen
AU  - Arun Rajan
AU  - James L. Gulley
AU  - Maude Guillot-Delost
AU  - Christophe Le Tourneau
AU  - Hélène Salmon
PY  - 2026
JO  - Journal of Clinical Investigation
DO  - 10.1172/jci198718
UR  - https://doi.org/10.1172/jci198718
ER  -

APA

Hoffmann, C., Werle, J., Sirven, P., Andrianteranagna, M., Gal, J., Lassoued, W., Klijanienko, J., Mesple, J., Demaille, B., Abbas, A., Gauthier, V., Borgman, K. J., Puisieux, I., Hreich, S. J. D., Choussy, O., Marret, G., Lameiras, S., Badois, N., Dubray-Vautrin, A., Dolivet, G., Geoffrois, L., Leclère, R., Zeitouni, W., Robil, N., Merlevede, J., Zhubanchaliyev, A., Kamal, M., Bieche, I., Monard, L., Simon, C., Louis, D., Allen, C. T., Rajan, A., Gulley, J. L., Guillot-Delost, M., Tourneau, C. L., & Salmon, H. (2026). Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients. Journal of Clinical Investigation. https://doi.org/10.1172/jci198718

Source records

crossref · retrieved 2026-11-04T10:31:17.320Z