Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

Ananthapadmanabhan V, Bruno S, Vonk L, Cheng YC, Teshager A, Eschle BK, Howarth CL, Rodrigues JS, Schnabel J, Kodali A, Gokhale PC, Kshirsagar R, Breitkopf SB, Sharma K, Paulo JA, Li Y, Cherniack AD, Michor F, Chutake Y, Dey J, DeCaprio JA

Open source

DOI: 10.1172/jci199049
Published: 2026 Jul 1
Container: The Journal of clinical investigation
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1172/jci199049,
  title = {Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.},
  author = {Ananthapadmanabhan V and Bruno S and Vonk L and Cheng YC and Teshager A and Eschle BK and Howarth CL and Rodrigues JS and Schnabel J and Kodali A and Gokhale PC and Kshirsagar R and Breitkopf SB and Sharma K and Paulo JA and Li Y and Cherniack AD and Michor F and Chutake Y and Dey J and DeCaprio JA},
  year = {2026},
  journal = {The Journal of clinical investigation},
  doi = {10.1172/jci199049},
  url = {https://doi.org/10.1172/jci199049}
}

RIS

TY  - JOUR
TI  - Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.
AU  - Ananthapadmanabhan V
AU  - Bruno S
AU  - Vonk L
AU  - Cheng YC
AU  - Teshager A
AU  - Eschle BK
AU  - Howarth CL
AU  - Rodrigues JS
AU  - Schnabel J
AU  - Kodali A
AU  - Gokhale PC
AU  - Kshirsagar R
AU  - Breitkopf SB
AU  - Sharma K
AU  - Paulo JA
AU  - Li Y
AU  - Cherniack AD
AU  - Michor F
AU  - Chutake Y
AU  - Dey J
AU  - DeCaprio JA
PY  - 2026
JO  - The Journal of clinical investigation
DO  - 10.1172/jci199049
UR  - https://doi.org/10.1172/jci199049
ER  -

APA

V, A., S, B., L, V., YC, C., A, T., BK, E., CL, H., JS, R., J, S., A, K., PC, G., R, K., SB, B., K, S., JA, P., Y, L., AD, C., F, M., Y, C., J, D., & JA, D. (2026). Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.. The Journal of clinical investigation. https://doi.org/10.1172/jci199049

Source records

pubmed · retrieved 2026-09-25T02:10:41.048Z