Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.

Xiao T, Brewer JR, Carlino M, Han A, Takabe YJ, Lee CY, Zhang F, Chen M, Blackburn HN, Nassar AH, Wang Q, Brennand K, Shan L, Sefik E, Krause DS, Flavell RA

Open source

DOI: 10.1172/jci207530
Published: 2026 Sep 15
Container: The Journal of clinical investigation
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1172/jci207530,
  title = {Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.},
  author = {Xiao T and Brewer JR and Carlino M and Han A and Takabe YJ and Lee CY and Zhang F and Chen M and Blackburn HN and Nassar AH and Wang Q and Brennand K and Shan L and Sefik E and Krause DS and Flavell RA},
  year = {2026},
  journal = {The Journal of clinical investigation},
  doi = {10.1172/jci207530},
  url = {https://doi.org/10.1172/jci207530}
}

RIS

TY  - JOUR
TI  - Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.
AU  - Xiao T
AU  - Brewer JR
AU  - Carlino M
AU  - Han A
AU  - Takabe YJ
AU  - Lee CY
AU  - Zhang F
AU  - Chen M
AU  - Blackburn HN
AU  - Nassar AH
AU  - Wang Q
AU  - Brennand K
AU  - Shan L
AU  - Sefik E
AU  - Krause DS
AU  - Flavell RA
PY  - 2026
JO  - The Journal of clinical investigation
DO  - 10.1172/jci207530
UR  - https://doi.org/10.1172/jci207530
ER  -

APA

T, X., JR, B., M, C., A, H., YJ, T., CY, L., F, Z., M, C., HN, B., AH, N., Q, W., K, B., L, S., E, S., DS, K., & RA, F. (2026). Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.. The Journal of clinical investigation. https://doi.org/10.1172/jci207530

Source records

pubmed · retrieved 2026-09-25T21:14:31.685Z