Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies

Lucia Y. Chen, Adolfo Aleman, Marta Larrayoz, Hsiling Chiu, Junfei Zhao, Oliver Van Oekelen, Geoffrey Kelly, Seunghee Kim-Schulz, Alessandro Lagana, Sundar Jagannath, Tracy T. Chow, Teresa Lozano, Juan J. Lasarte, Joseph Hamley, Warren Baker, Benjamin L. Ebert, Udo Oppermann, Michael Amatangelo, Anita K. Gandhi, Patrick R. Hagner, Jose A. Martinez-Climent, Sarah Gooding, Thomas A. Milne, Samir Parekh

Open source

DOI: 10.1182/blood.2025030891
Published: 2026-08-27
Container: Blood
Publisher: American Society of Hematology
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1182/blood.2025030891,
  title = {Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies},
  author = {Lucia Y. Chen and Adolfo Aleman and Marta Larrayoz and Hsiling Chiu and Junfei Zhao and Oliver Van Oekelen and Geoffrey Kelly and Seunghee Kim-Schulz and Alessandro Lagana and Sundar Jagannath and Tracy T. Chow and Teresa Lozano and Juan J. Lasarte and Joseph Hamley and Warren Baker and Benjamin L. Ebert and Udo Oppermann and Michael Amatangelo and Anita K. Gandhi and Patrick R. Hagner and Jose A. Martinez-Climent and Sarah Gooding and Thomas A. Milne and Samir Parekh},
  year = {2026},
  journal = {Blood},
  doi = {10.1182/blood.2025030891},
  url = {https://doi.org/10.1182/blood.2025030891}
}

RIS

TY  - JOUR
TI  - Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies
AU  - Lucia Y. Chen
AU  - Adolfo Aleman
AU  - Marta Larrayoz
AU  - Hsiling Chiu
AU  - Junfei Zhao
AU  - Oliver Van Oekelen
AU  - Geoffrey Kelly
AU  - Seunghee Kim-Schulz
AU  - Alessandro Lagana
AU  - Sundar Jagannath
AU  - Tracy T. Chow
AU  - Teresa Lozano
AU  - Juan J. Lasarte
AU  - Joseph Hamley
AU  - Warren Baker
AU  - Benjamin L. Ebert
AU  - Udo Oppermann
AU  - Michael Amatangelo
AU  - Anita K. Gandhi
AU  - Patrick R. Hagner
AU  - Jose A. Martinez-Climent
AU  - Sarah Gooding
AU  - Thomas A. Milne
AU  - Samir Parekh
PY  - 2026
JO  - Blood
DO  - 10.1182/blood.2025030891
UR  - https://doi.org/10.1182/blood.2025030891
ER  -

APA

Chen, L. Y., Aleman, A., Larrayoz, M., Chiu, H., Zhao, J., Oekelen, O. V., Kelly, G., Kim-Schulz, S., Lagana, A., Jagannath, S., Chow, T. T., Lozano, T., Lasarte, J. J., Hamley, J., Baker, W., Ebert, B. L., Oppermann, U., Amatangelo, M., Gandhi, A. K., Hagner, P. R., Martinez-Climent, J. A., Gooding, S., Milne, T. A., & Parekh, S. (2026). Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies. Blood. https://doi.org/10.1182/blood.2025030891

Source records

crossref · retrieved 2026-09-26T04:49:07.119Z