Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6).

Rovers KP, Bakkers C, Simkens GAAM, Burger JWA, Nienhuijs SW, Creemers GM, Thijs AMJ, Brandt-Kerkhof ARM, Madsen EVE, Ayez N, de Boer NL, van Meerten E, Tuynman JB, Kusters M, Sluiter NR, Verheul HMW, van der Vliet HJ, Wiezer MJ, Boerma D, Wassenaar ECE, Los M, Hunting CB, Aalbers AGJ, Kok NFM, Kuhlmann KFD, Boot H, Chalabi M, Kruijff S, Been LB, van Ginkel RJ, de Groot DJA, Fehrmann RSN, de Wilt JHW, Bremers AJA, de Reuver PR, Radema SA, Herbschleb KH, van Grevenstein WMU, Witkamp AJ, Koopman M, Haj Mohammad N, van Duyn EB, Mastboom WJB, Mekenkamp LJM, Nederend J, Lahaye MJ, Snaebjornsson P, Verhoef C, van Laarhoven HWM, Zwinderman AH, Bouma JM, Kranenburg O, van 't Erve I, Fijneman RJA, Dijkgraaf MGW, Hemmer PHJ, Punt CJA, Tanis PJ, de Hingh IHJT, Dutch Peritoneal Oncology Group (DPOG), Dutch Colorectal Cancer Group (DCCG)

Open source

DOI: 10.1186/s12885-019-5545-0
Published: 2019 Apr 25
Container: BMC cancer
Publisher: Not recorded
Open access: yes

Credibility signals

uncertain Score 53/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
supportingDirectory of Open Access Journals: A matching record was returned by DOAJ. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1186/s12885-019-5545-0,
  title = {Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6).},
  author = {Rovers KP and Bakkers C and Simkens GAAM and Burger JWA and Nienhuijs SW and Creemers GM and Thijs AMJ and Brandt-Kerkhof ARM and Madsen EVE and Ayez N and de Boer NL and van Meerten E and Tuynman JB and Kusters M and Sluiter NR and Verheul HMW and van der Vliet HJ and Wiezer MJ and Boerma D and Wassenaar ECE and Los M and Hunting CB and Aalbers AGJ and Kok NFM and Kuhlmann KFD and Boot H and Chalabi M and Kruijff S and Been LB and van Ginkel RJ and de Groot DJA and Fehrmann RSN and de Wilt JHW and Bremers AJA and de Reuver PR and Radema SA and Herbschleb KH and van Grevenstein WMU and Witkamp AJ and Koopman M and Haj Mohammad N and van Duyn EB and Mastboom WJB and Mekenkamp LJM and Nederend J and Lahaye MJ and Snaebjornsson P and Verhoef C and van Laarhoven HWM and Zwinderman AH and Bouma JM and Kranenburg O and van 't Erve I and Fijneman RJA and Dijkgraaf MGW and Hemmer PHJ and Punt CJA and Tanis PJ and de Hingh IHJT and Dutch Peritoneal Oncology Group (DPOG) and Dutch Colorectal Cancer Group (DCCG)},
  year = {2019},
  journal = {BMC cancer},
  doi = {10.1186/s12885-019-5545-0},
  url = {https://doi.org/10.1186/s12885-019-5545-0}
}

RIS

TY  - JOUR
TI  - Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6).
AU  - Rovers KP
AU  - Bakkers C
AU  - Simkens GAAM
AU  - Burger JWA
AU  - Nienhuijs SW
AU  - Creemers GM
AU  - Thijs AMJ
AU  - Brandt-Kerkhof ARM
AU  - Madsen EVE
AU  - Ayez N
AU  - de Boer NL
AU  - van Meerten E
AU  - Tuynman JB
AU  - Kusters M
AU  - Sluiter NR
AU  - Verheul HMW
AU  - van der Vliet HJ
AU  - Wiezer MJ
AU  - Boerma D
AU  - Wassenaar ECE
AU  - Los M
AU  - Hunting CB
AU  - Aalbers AGJ
AU  - Kok NFM
AU  - Kuhlmann KFD
AU  - Boot H
AU  - Chalabi M
AU  - Kruijff S
AU  - Been LB
AU  - van Ginkel RJ
AU  - de Groot DJA
AU  - Fehrmann RSN
AU  - de Wilt JHW
AU  - Bremers AJA
AU  - de Reuver PR
AU  - Radema SA
AU  - Herbschleb KH
AU  - van Grevenstein WMU
AU  - Witkamp AJ
AU  - Koopman M
AU  - Haj Mohammad N
AU  - van Duyn EB
AU  - Mastboom WJB
AU  - Mekenkamp LJM
AU  - Nederend J
AU  - Lahaye MJ
AU  - Snaebjornsson P
AU  - Verhoef C
AU  - van Laarhoven HWM
AU  - Zwinderman AH
AU  - Bouma JM
AU  - Kranenburg O
AU  - van 't Erve I
AU  - Fijneman RJA
AU  - Dijkgraaf MGW
AU  - Hemmer PHJ
AU  - Punt CJA
AU  - Tanis PJ
AU  - de Hingh IHJT
AU  - Dutch Peritoneal Oncology Group (DPOG)
AU  - Dutch Colorectal Cancer Group (DCCG)
PY  - 2019
JO  - BMC cancer
DO  - 10.1186/s12885-019-5545-0
UR  - https://doi.org/10.1186/s12885-019-5545-0
ER  -

APA

KP, R., C, B., GAAM, S., JWA, B., SW, N., GM, C., AMJ, T., ARM, B., EVE, M., N, A., NL, D. B., E, V. M., JB, T., M, K., NR, S., HMW, V., HJ, V. D. V., MJ, W., D, B., ECE, W., M, L., CB, H., AGJ, A., NFM, K., KFD, K., H, B., M, C., S, K., LB, B., RJ, V. G., DJA, D. G., RSN, F., JHW, D. W., AJA, B., PR, D. R., SA, R., KH, H., WMU, V. G., AJ, W., M, K., N, H. M., EB, V. D., WJB, M., LJM, M., J, N., MJ, L., P, S., C, V., HWM, V. L., AH, Z., JM, B., O, K., I, V. '. E., RJA, F., MGW, D., PHJ, H., CJA, P., PJ, T., IHJT, D. H., (DPOG), D. P. O. G., & (DCCG), D. C. C. G. (2019). Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6).. BMC cancer. https://doi.org/10.1186/s12885-019-5545-0

Source records

pubmed · retrieved 2026-09-25T19:38:07.882Z
europe-pmc · retrieved 2026-09-25T19:38:07.904Z
doaj · retrieved 2026-09-25T19:38:07.913Z