Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.

Gile B, Bulbule S, Toriola MA, Ruan BT, Marium S, Benko A, Grach S, Mueller M, Bateman L, Bell J, Yellman B, Berner J, Chheda B, Kaufman D, Gottschalk G, Roy A

Open source

DOI: 10.1186/s12967-026-08575-3
Published: 2026 Jul 10
Container: Journal of translational medicine
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1186/s12967-026-08575-3,
  title = {Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.},
  author = {Gile B and Bulbule S and Toriola MA and Ruan BT and Marium S and Benko A and Grach S and Mueller M and Bateman L and Bell J and Yellman B and Berner J and Chheda B and Kaufman D and Gottschalk G and Roy A},
  year = {2026},
  journal = {Journal of translational medicine},
  doi = {10.1186/s12967-026-08575-3},
  url = {https://doi.org/10.1186/s12967-026-08575-3}
}

RIS

TY  - JOUR
TI  - Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.
AU  - Gile B
AU  - Bulbule S
AU  - Toriola MA
AU  - Ruan BT
AU  - Marium S
AU  - Benko A
AU  - Grach S
AU  - Mueller M
AU  - Bateman L
AU  - Bell J
AU  - Yellman B
AU  - Berner J
AU  - Chheda B
AU  - Kaufman D
AU  - Gottschalk G
AU  - Roy A
PY  - 2026
JO  - Journal of translational medicine
DO  - 10.1186/s12967-026-08575-3
UR  - https://doi.org/10.1186/s12967-026-08575-3
ER  -

APA

B, G., S, B., MA, T., BT, R., S, M., A, B., S, G., M, M., L, B., J, B., B, Y., J, B., B, C., D, K., G, G., & A, R. (2026). Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.. Journal of translational medicine. https://doi.org/10.1186/s12967-026-08575-3

Source records

pubmed · retrieved 2026-09-25T10:54:16.730Z