Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease

BibTeX

@article{allodium:10.1186/s13059-025-03564-z,
  title = {Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease},
  author = {Farid Rajabli and Penelope Benchek and Giuseppe Tosto and Nicholas Kushch and Jin Sha and Katrina Bazemore and Congcong Zhu and Wan-Ping Lee and Jacob Haut and Kara L. Hamilton-Nelson and Nicholas R. Wheeler and Yi Zhao and John J. Farrell and Michelle A. Grunin and Yuk Yee Leung and Pavel P. Kuksa and Donghe Li and Eder Lucio da Fonseca and Jesse B. Mez and Ellen L. Palmer and Jagan Pillai and Richard M. Sherva and Yeunjoo E. Song and Xiaoling Zhang and Takeshi Ikeuchi and Taha Iqbal and Omkar Pathak and Otto Valladares and Dolly Reyes-Dumeyer and Amanda B. Kuzma and Erin Abner and Larry D. Adams and Perrie M. Adams and Alyssa Aguirre and Marilyn S. Albert and Roger L. Albin and Mariet Allen and Lisa Alvarez and Liana G. Apostolova and Steven E. Arnold and Sanjay Asthana and Craig S. Atwood and Sanford Auerbach and Gayle Ayres and Clinton T. Baldwin and Robert C. Barber and Lisa L. Barnes and Sandra Barral and Thomas G. Beach and James T. Becker and Gary W. Beecham and Duane Beekly and Bruno A. Benitez and David Bennett and John Bertelson and Thomas D. Bird and Deborah Blacker and Bradley F. Boeve and James D. Bowen and Adam Boxer and James Brewer and James R. Burke and Jeffrey M. Burns and Joseph D. Buxbaum and Nigel J. Cairns and Laura B. Cantwell and Chuanhai Cao and Christopher S. Carlson and Cynthia M. Carlsson and Regina M. Carney and Minerva M. Carrasquillo and Scott Chasse and Marie-Francoise Chesselet and Nathaniel A. Chin and Helena C. Chui and Jaeyoon Chung and Suzanne Craft and Paul K. Crane and David H. Cribbs and Elizabeth A. Crocco and Carlos Cruchaga and Michael L. Cuccaro and Munro Cullum and Eveleen Darby and Barbara Davis and Philip L. De Jager and Charles DeCarli and John DeToledo and Malcolm Dick and Dennis W. Dickson and Beth A. Dombroski and Rachelle S. Doody and Ranjan Duara and NIlüfer Ertekin-Taner and Denis A. Evans and Kelley M. Faber and Thomas J. Fairchild and Kenneth B. Fallon and David W. Fardo and Martin R. Farlow and Victoria Fernandez-Hernandez and Steven Ferris and Robert P. Friedland and Tatiana M. Foroud and Matthew P. Frosch and Brian Fulton-Howard and Douglas R. Galasko and Adriana Gamboa and Marla Gearing and Daniel H. Geschwind and Bernardino Ghetti and John R. Gilbert and Rodney C.P. Go and Alison M. Goate and Thomas J. Grabowski and Neill R. Graff-Radford and Robert C. Green and John H. Growdon and Hakon Hakonarson and James Hall and Ronald L. Hamilton and Oscar Harari and John Hardy and Lindy E. Harrell and Elizabeth Head and Victor W. Henderson and Michelle Hernandez and Timothy Hohman and Lawrence S. Honig and Ryan M. Huebinger and Matthew J. Huentelman and Christine M. Hulette and Bradley T. Hyman and Linda S. Hynan and Laura Ibanez and Gail P. Jarvik and Suman Jayadev and Lee-Way Jin and Kim Johnson and Leigh Johnson and M. Ilyas Kamboh and Anna M. Karydas and Mindy J. Katz and John S. Kauwe and Jeffrey A. Kaye and C. Dirk Keene and Aisha Khaleeq and Masataka Kikuchi and Ronald Kim and Janice Knebl and Neil W. Kowall and Joel H. Kramer and Walter A. Kukull and Frank M. LaFerla and James J. Lah and Eric B. Larson and Alan Lerner and James B. Leverenz and Allan I. Levey and Andrew P. Lieberman and Richard B. Lipton and Mark Logue and Oscar L. Lopez and Kathryn L. Lunetta and Constantine G. Lyketsos and Douglas Mains and Flanagan E. Margaret and Daniel C. Marson and Eden RR. Martin and Frank Martiniuk and Deborah C. Mash and Eliezer Masliah and Paul Massman and Arjun Masurkar and Wayne C. McCormick and Susan M. McCurry and Andrew N. McDavid and Stefan McDonough and Ann C. McKee and Marsel Mesulam and Bruce L. Miller and Carol A. Miller and Joshua W. Miller and Thomas J. Montine and Edwin S. Monuki and John C. Morris and Shubhabrata Mukherjee and Amanda J. Myers and Trung Nguyen and Thomas Obisesan and Sid O’Bryant and John M. Olichney and Marcia Ory and Raymond Palmer and Joseph E. Parisi and Henry L. Paulson and Valory Pavlik and David Paydarfar and Victoria Perez and Elaine Peskind and Ronald C. Petersen and Helen Petrovitch and Aimee Pierce and Marsha Polk and Wayne W. Poon and Huntington Potter and Liming Qu and Mary Quiceno and Joseph F. Quinn and Ashok Raj and Murray Raskind and Eric M. Reiman and Barry Reisberg and Joan S. Reisch and John M. Ringman and Erik D. Roberson and Monica Rodriguear and Ekaterina Rogaeva and Howard J. Rosen and Roger N. Rosenberg and Donald R. Royall and Marwan Sabbagh and A. Dessa Sadovnick and Mark A. Sager and Mary Sano and Andrew J. Saykin and Julie A. Schneider and Lon S. Schneider and William W. Seeley and Susan H. Slifer and Scott Small and Amanda G. Smith and Janet P. Smith and Joshua A. Sonnen and Salvatore Spina and Peter St George-Hyslop and Takiyah D. Starks and Robert A. Stern and Alan B. Stevens and Stephen M. Strittmatter and David Sultzer and Russell H. Swerdlow and Rudolph E. Tanzi and Jeffrey L. Tilson and John Q. Trojanowski and Juan C. Troncoso and Magda Tsolaki and Debby W. Tsuang and Vivianna M. Van Deerlin and Linda J. van Eldik and Jeffery M. Vance and Badri N. Vardarajan and Robert Vassar and Harry V. Vinters and Jean-Paul Vonsattel and Sandra Weintraub and Kathleen A. Welsh-Bohmer and Patrice L. Whitehead and Ellen M. Wijsman and Kirk C. Wilhelmsen and Benjamin Williams and Jennifer Williamson and Henrik Wilms and Thomas S. Wingo and Thomas Wisniewski and Randall L. Woltjer and Martin Woon and Clinton B. Wright and Chuang-Kuo Wu and Steven G. Younkin and Chang-En Yu and Lei Yu and Xiongwei Zhu and Brian W. Kunkle and William S. Bush and Akinori Miyashita and Goldie S. Byrd and Li-San Wang and Lindsay A. Farrer and Jonathan L. Haines and Richard Mayeux and Margaret A. Pericak-Vance and Gerard D. Schellenberg and Gyungah R. Jun and Christiane Reitz and Adam C. Naj and Unknown},
  year = {2025},
  journal = {Genome Biology},
  doi = {10.1186/s13059-025-03564-z},
  url = {https://doi.org/10.1186/s13059-025-03564-z}
}

RIS

TY  - JOUR
TI  - Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease
AU  - Farid Rajabli
AU  - Penelope Benchek
AU  - Giuseppe Tosto
AU  - Nicholas Kushch
AU  - Jin Sha
AU  - Katrina Bazemore
AU  - Congcong Zhu
AU  - Wan-Ping Lee
AU  - Jacob Haut
AU  - Kara L. Hamilton-Nelson
AU  - Nicholas R. Wheeler
AU  - Yi Zhao
AU  - John J. Farrell
AU  - Michelle A. Grunin
AU  - Yuk Yee Leung
AU  - Pavel P. Kuksa
AU  - Donghe Li
AU  - Eder Lucio da Fonseca
AU  - Jesse B. Mez
AU  - Ellen L. Palmer
AU  - Jagan Pillai
AU  - Richard M. Sherva
AU  - Yeunjoo E. Song
AU  - Xiaoling Zhang
AU  - Takeshi Ikeuchi
AU  - Taha Iqbal
AU  - Omkar Pathak
AU  - Otto Valladares
AU  - Dolly Reyes-Dumeyer
AU  - Amanda B. Kuzma
AU  - Erin Abner
AU  - Larry D. Adams
AU  - Perrie M. Adams
AU  - Alyssa Aguirre
AU  - Marilyn S. Albert
AU  - Roger L. Albin
AU  - Mariet Allen
AU  - Lisa Alvarez
AU  - Liana G. Apostolova
AU  - Steven E. Arnold
AU  - Sanjay Asthana
AU  - Craig S. Atwood
AU  - Sanford Auerbach
AU  - Gayle Ayres
AU  - Clinton T. Baldwin
AU  - Robert C. Barber
AU  - Lisa L. Barnes
AU  - Sandra Barral
AU  - Thomas G. Beach
AU  - James T. Becker
AU  - Gary W. Beecham
AU  - Duane Beekly
AU  - Bruno A. Benitez
AU  - David Bennett
AU  - John Bertelson
AU  - Thomas D. Bird
AU  - Deborah Blacker
AU  - Bradley F. Boeve
AU  - James D. Bowen
AU  - Adam Boxer
AU  - James Brewer
AU  - James R. Burke
AU  - Jeffrey M. Burns
AU  - Joseph D. Buxbaum
AU  - Nigel J. Cairns
AU  - Laura B. Cantwell
AU  - Chuanhai Cao
AU  - Christopher S. Carlson
AU  - Cynthia M. Carlsson
AU  - Regina M. Carney
AU  - Minerva M. Carrasquillo
AU  - Scott Chasse
AU  - Marie-Francoise Chesselet
AU  - Nathaniel A. Chin
AU  - Helena C. Chui
AU  - Jaeyoon Chung
AU  - Suzanne Craft
AU  - Paul K. Crane
AU  - David H. Cribbs
AU  - Elizabeth A. Crocco
AU  - Carlos Cruchaga
AU  - Michael L. Cuccaro
AU  - Munro Cullum
AU  - Eveleen Darby
AU  - Barbara Davis
AU  - Philip L. De Jager
AU  - Charles DeCarli
AU  - John DeToledo
AU  - Malcolm Dick
AU  - Dennis W. Dickson
AU  - Beth A. Dombroski
AU  - Rachelle S. Doody
AU  - Ranjan Duara
AU  - NIlüfer Ertekin-Taner
AU  - Denis A. Evans
AU  - Kelley M. Faber
AU  - Thomas J. Fairchild
AU  - Kenneth B. Fallon
AU  - David W. Fardo
AU  - Martin R. Farlow
AU  - Victoria Fernandez-Hernandez
AU  - Steven Ferris
AU  - Robert P. Friedland
AU  - Tatiana M. Foroud
AU  - Matthew P. Frosch
AU  - Brian Fulton-Howard
AU  - Douglas R. Galasko
AU  - Adriana Gamboa
AU  - Marla Gearing
AU  - Daniel H. Geschwind
AU  - Bernardino Ghetti
AU  - John R. Gilbert
AU  - Rodney C.P. Go
AU  - Alison M. Goate
AU  - Thomas J. Grabowski
AU  - Neill R. Graff-Radford
AU  - Robert C. Green
AU  - John H. Growdon
AU  - Hakon Hakonarson
AU  - James Hall
AU  - Ronald L. Hamilton
AU  - Oscar Harari
AU  - John Hardy
AU  - Lindy E. Harrell
AU  - Elizabeth Head
AU  - Victor W. Henderson
AU  - Michelle Hernandez
AU  - Timothy Hohman
AU  - Lawrence S. Honig
AU  - Ryan M. Huebinger
AU  - Matthew J. Huentelman
AU  - Christine M. Hulette
AU  - Bradley T. Hyman
AU  - Linda S. Hynan
AU  - Laura Ibanez
AU  - Gail P. Jarvik
AU  - Suman Jayadev
AU  - Lee-Way Jin
AU  - Kim Johnson
AU  - Leigh Johnson
AU  - M. Ilyas Kamboh
AU  - Anna M. Karydas
AU  - Mindy J. Katz
AU  - John S. Kauwe
AU  - Jeffrey A. Kaye
AU  - C. Dirk Keene
AU  - Aisha Khaleeq
AU  - Masataka Kikuchi
AU  - Ronald Kim
AU  - Janice Knebl
AU  - Neil W. Kowall
AU  - Joel H. Kramer
AU  - Walter A. Kukull
AU  - Frank M. LaFerla
AU  - James J. Lah
AU  - Eric B. Larson
AU  - Alan Lerner
AU  - James B. Leverenz
AU  - Allan I. Levey
AU  - Andrew P. Lieberman
AU  - Richard B. Lipton
AU  - Mark Logue
AU  - Oscar L. Lopez
AU  - Kathryn L. Lunetta
AU  - Constantine G. Lyketsos
AU  - Douglas Mains
AU  - Flanagan E. Margaret
AU  - Daniel C. Marson
AU  - Eden RR. Martin
AU  - Frank Martiniuk
AU  - Deborah C. Mash
AU  - Eliezer Masliah
AU  - Paul Massman
AU  - Arjun Masurkar
AU  - Wayne C. McCormick
AU  - Susan M. McCurry
AU  - Andrew N. McDavid
AU  - Stefan McDonough
AU  - Ann C. McKee
AU  - Marsel Mesulam
AU  - Bruce L. Miller
AU  - Carol A. Miller
AU  - Joshua W. Miller
AU  - Thomas J. Montine
AU  - Edwin S. Monuki
AU  - John C. Morris
AU  - Shubhabrata Mukherjee
AU  - Amanda J. Myers
AU  - Trung Nguyen
AU  - Thomas Obisesan
AU  - Sid O’Bryant
AU  - John M. Olichney
AU  - Marcia Ory
AU  - Raymond Palmer
AU  - Joseph E. Parisi
AU  - Henry L. Paulson
AU  - Valory Pavlik
AU  - David Paydarfar
AU  - Victoria Perez
AU  - Elaine Peskind
AU  - Ronald C. Petersen
AU  - Helen Petrovitch
AU  - Aimee Pierce
AU  - Marsha Polk
AU  - Wayne W. Poon
AU  - Huntington Potter
AU  - Liming Qu
AU  - Mary Quiceno
AU  - Joseph F. Quinn
AU  - Ashok Raj
AU  - Murray Raskind
AU  - Eric M. Reiman
AU  - Barry Reisberg
AU  - Joan S. Reisch
AU  - John M. Ringman
AU  - Erik D. Roberson
AU  - Monica Rodriguear
AU  - Ekaterina Rogaeva
AU  - Howard J. Rosen
AU  - Roger N. Rosenberg
AU  - Donald R. Royall
AU  - Marwan Sabbagh
AU  - A. Dessa Sadovnick
AU  - Mark A. Sager
AU  - Mary Sano
AU  - Andrew J. Saykin
AU  - Julie A. Schneider
AU  - Lon S. Schneider
AU  - William W. Seeley
AU  - Susan H. Slifer
AU  - Scott Small
AU  - Amanda G. Smith
AU  - Janet P. Smith
AU  - Joshua A. Sonnen
AU  - Salvatore Spina
AU  - Peter St George-Hyslop
AU  - Takiyah D. Starks
AU  - Robert A. Stern
AU  - Alan B. Stevens
AU  - Stephen M. Strittmatter
AU  - David Sultzer
AU  - Russell H. Swerdlow
AU  - Rudolph E. Tanzi
AU  - Jeffrey L. Tilson
AU  - John Q. Trojanowski
AU  - Juan C. Troncoso
AU  - Magda Tsolaki
AU  - Debby W. Tsuang
AU  - Vivianna M. Van Deerlin
AU  - Linda J. van Eldik
AU  - Jeffery M. Vance
AU  - Badri N. Vardarajan
AU  - Robert Vassar
AU  - Harry V. Vinters
AU  - Jean-Paul Vonsattel
AU  - Sandra Weintraub
AU  - Kathleen A. Welsh-Bohmer
AU  - Patrice L. Whitehead
AU  - Ellen M. Wijsman
AU  - Kirk C. Wilhelmsen
AU  - Benjamin Williams
AU  - Jennifer Williamson
AU  - Henrik Wilms
AU  - Thomas S. Wingo
AU  - Thomas Wisniewski
AU  - Randall L. Woltjer
AU  - Martin Woon
AU  - Clinton B. Wright
AU  - Chuang-Kuo Wu
AU  - Steven G. Younkin
AU  - Chang-En Yu
AU  - Lei Yu
AU  - Xiongwei Zhu
AU  - Brian W. Kunkle
AU  - William S. Bush
AU  - Akinori Miyashita
AU  - Goldie S. Byrd
AU  - Li-San Wang
AU  - Lindsay A. Farrer
AU  - Jonathan L. Haines
AU  - Richard Mayeux
AU  - Margaret A. Pericak-Vance
AU  - Gerard D. Schellenberg
AU  - Gyungah R. Jun
AU  - Christiane Reitz
AU  - Adam C. Naj
AU  - Unknown
PY  - 2025
JO  - Genome Biology
DO  - 10.1186/s13059-025-03564-z
UR  - https://doi.org/10.1186/s13059-025-03564-z
ER  - 

APA

Rajabli, F., Benchek, P., Tosto, G., Kushch, N., Sha, J., Bazemore, K., Zhu, C., Lee, W., Haut, J., Hamilton-Nelson, K. L., Wheeler, N. R., Zhao, Y., Farrell, J. J., Grunin, M. A., Leung, Y. Y., Kuksa, P. P., Li, D., Fonseca, E. L. D., Mez, J. B., Palmer, E. L., Pillai, J., Sherva, R. M., Song, Y. E., Zhang, X., Ikeuchi, T., Iqbal, T., Pathak, O., Valladares, O., Reyes-Dumeyer, D., Kuzma, A. B., Abner, E., Adams, L. D., Adams, P. M., Aguirre, A., Albert, M. S., Albin, R. L., Allen, M., Alvarez, L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Auerbach, S., Ayres, G., Baldwin, C. T., Barber, R. C., Barnes, L. L., Barral, S., Beach, T. G., Becker, J. T., Beecham, G. W., Beekly, D., Benitez, B. A., Bennett, D., Bertelson, J., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Brewer, J., Burke, J. R., Burns, J. M., Buxbaum, J. D., Cairns, N. J., Cantwell, L. B., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Chasse, S., Chesselet, M., Chin, N. A., Chui, H. C., Chung, J., Craft, S., Crane, P. K., Cribbs, D. H., Crocco, E. A., Cruchaga, C., Cuccaro, M. L., Cullum, M., Darby, E., Davis, B., Jager, P. L. D., DeCarli, C., DeToledo, J., Dick, M., Dickson, D. W., Dombroski, B. A., Doody, R. S., Duara, R., Ertekin-Taner, N., Evans, D. A., Faber, K. M., Fairchild, T. J., Fallon, K. B., Fardo, D. W., Farlow, M. R., Fernandez-Hernandez, V., Ferris, S., Friedland, R. P., Foroud, T. M., Frosch, M. P., Fulton-Howard, B., Galasko, D. R., Gamboa, A., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Go, R. C., Goate, A. M., Grabowski, T. J., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hakonarson, H., Hall, J., Hamilton, R. L., Harari, O., Hardy, J., Harrell, L. E., Head, E., Henderson, V. W., Hernandez, M., Hohman, T., Honig, L. S., Huebinger, R. M., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Hynan, L. S., Ibanez, L., Jarvik, G. P., Jayadev, S., Jin, L., Johnson, K., Johnson, L., Kamboh, M. I., Karydas, A. M., Katz, M. J., Kauwe, J. S., Kaye, J. A., Keene, C. D., Khaleeq, A., Kikuchi, M., Kim, R., Knebl, J., Kowall, N. W., Kramer, J. H., Kukull, W. A., LaFerla, F. M., Lah, J. J., Larson, E. B., Lerner, A., Leverenz, J. B., Levey, A. I., Lieberman, A. P., Lipton, R. B., Logue, M., Lopez, O. L., Lunetta, K. L., Lyketsos, C. G., Mains, D., Margaret, F. E., Marson, D. C., Martin, E. R., Martiniuk, F., Mash, D. C., Masliah, E., Massman, P., Masurkar, A., McCormick, W. C., McCurry, S. M., McDavid, A. N., McDonough, S., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Monuki, E. S., Morris, J. C., Mukherjee, S., Myers, A. J., Nguyen, T., Obisesan, T., O’Bryant, S., Olichney, J. M., Ory, M., Palmer, R., Parisi, J. E., Paulson, H. L., Pavlik, V., Paydarfar, D., Perez, V., Peskind, E., Petersen, R. C., Petrovitch, H., Pierce, A., Polk, M., Poon, W. W., Potter, H., Qu, L., Quiceno, M., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reisch, J. S., Ringman, J. M., Roberson, E. D., Rodriguear, M., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sabbagh, M., Sadovnick, A. D., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Slifer, S. H., Small, S., Smith, A. G., Smith, J. P., Sonnen, J. A., Spina, S., George-Hyslop, P. S., Starks, T. D., Stern, R. A., Stevens, A. B., Strittmatter, S. M., Sultzer, D., Swerdlow, R. H., Tanzi, R. E., Tilson, J. L., Trojanowski, J. Q., Troncoso, J. C., Tsolaki, M., Tsuang, D. W., Deerlin, V. M. V., Eldik, L. J. V., Vance, J. M., Vardarajan, B. N., Vassar, R., Vinters, H. V., Vonsattel, J., Weintraub, S., Welsh-Bohmer, K. A., Whitehead, P. L., Wijsman, E. M., Wilhelmsen, K. C., Williams, B., Williamson, J., Wilms, H., Wingo, T. S., Wisniewski, T., Woltjer, R. L., Woon, M., Wright, C. B., Wu, C., Younkin, S. G., Yu, C., Yu, L., Zhu, X., Kunkle, B. W., Bush, W. S., Miyashita, A., Byrd, G. S., Wang, L., Farrer, L. A., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Schellenberg, G. D., Jun, G. R., Reitz, C., Naj, A. C., & Unknown (2025). Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease. Genome Biology. https://doi.org/10.1186/s13059-025-03564-z