PROMISE: a PROspective randomised double-blind parallel group placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis over 24 months—study protocol for a clinical trial

Victoria T. Kronsten, Yevedzo Ntuli, Ellis Kobina Paintsil, Charlotte A. Woodhouse, Thomas H. Tranah, Sue Cheung, Daryl Hagan, Blair Merrick, Angela Cape, Francesca Maher, Kirin Sultana, Desiree Prossomariti, Steven Rodrigues, Christine Masterson, Vanessa Hebditch, Ane Zamalloa, Benjamin H. Mullish, Arjuna Singanayagam, Vishal C. Patel, Mark R. Thursz, Unknown, Gavin Wright, Manuel Jasper, Tahir Khan, Syeda Amber Ali, Sarah Fairclough, Bushena Miyesa, Michael Villaruel, Princess Gabiana, Keval Naik, Caroline Fox, Miranda Forsey, Prem Karthikeyan, Jennifer Child, Yvonne Lester, Gautham Appanna, Hannah Donnelly, Alice Lagnado, Robbie Adamson, Joanne Elliot, Gifthy Perez, Rose Fyfe-Beedell, Siby Varghese, Chiaki Shioi, Bindu Mary Jinesh, Shannah O’Sullivan, Hannah Whitehouse, Eunice Akintemi, Matthew Cramp, Glen Marsh, Angela Downing, Gabriella Smallwood, Sasa Topol, Nelly Imbwana, Natasha Wilmshurst, Kelly Bowers, Elanor Haughan, Steven Masson, Juliet Obhiozele, Sarah Hogg, Sheenu Thomas, Lynsey Corless, George Abouda, Kim Dearnley, Jane Rice, Lisa Burton, Julie Gracie, Angie Good, Amy Hicks, Ali Elgadari, Nurun Tania, Ani Kingsbury, Mark McPhail, Michael Ihimekpen, Ruairi Lynch, Damien Leith, Jude Wellens-Mensah, Ann Elliott, Leanne Cosgrove, Abigail Grieve, Paul Johnson, Dina Mansour, Rajan Bhandari, Ann Wilson, Dorothy Carman, Kara Wilshire, Rachael Swann, Laura Davidson, Michael Lumsden, Keziah Lewis, Dominic Rimmer, Faye McMeeken, Shona Perry, Nicole Stoddart, Kirsty Fallon, Lesley Gilmour, Hayley King, Deborah McGlynn, Katherine Burrows, Gemma Duff, Lauren Walker, Alexis Duncan, Guru Aithal, Robert Scott, Adina Olaru, Kimberley Noon, Sophie Cusick, Maria Baffa-Scineli, Amanda Cetroni, Sebastian Wallace, Clare Bradley, Salman Bhatta, Euan Humphreys, Fiona Barrett, Charlotte Barr, Andy Gibson, Valarie Anderson, Safa Al-Shamma, Lindsay Rogers, Fardowsa Ahmed-Timms, Annamaria Wilce, Nicholas Taylor, Andrew Austin, Claire Grant, Maggie Langley, Catherine Addleton, Jisha Joseph, Zeino Zeino, Ankur Srivastava, James Maurice, Lana Ward, Trudie Burge, Louise Jennings, Joseph Delo, Joana Teixeira, Criscel Jan Pelaez, Maria Belini, Amy Curtis, Annie Matthew, Samantha Taylor, Valentia Raspa, Khine Thu, Caroline Gosson, Victoria Comerford, Oluwadamilola Ogunrinde, Kim Sorley, Simon O’ Sullivan, Ian Rowe, Oliver Tavabie, Suzannah Dorey, Arshatisha Joe, Rebecca Bishop, Mehvish Hussain, Yasira Ghaseeta, Madeleine Graydon, Jonathan King, Gareth Hahn, Celia Diaz-Moore, James Neale, Pauline Mercer, Claire Stringer, Sophie Booth, Natasha McDonald, Emma Speake, Rebecca Rielly, Morag Murray, Maria McLaughlin, Sandra Newlands, Janisha Patel, Sofia Pires, Susan Samuel, Faith Panilagao-Bushi, Simon D. Goldenberg, Ben Carter, Lindsey A. Edwards, Debbie L. Shawcross

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DOI: 10.1186/s13063-026-09914-x
Published: 2026-07-31
Container: Trials
Publisher: Springer Science and Business Media LLC
Open access: unknown

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BibTeX

@article{allodium:10.1186/s13063-026-09914-x,
  title = {PROMISE: a PROspective randomised double-blind parallel group placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis over 24 months—study protocol for a clinical trial},
  author = {Victoria T. Kronsten and Yevedzo Ntuli and Ellis Kobina Paintsil and Charlotte A. Woodhouse and Thomas H. Tranah and Sue Cheung and Daryl Hagan and Blair Merrick and Angela Cape and Francesca Maher and Kirin Sultana and Desiree Prossomariti and Steven Rodrigues and Christine Masterson and Vanessa Hebditch and Ane Zamalloa and Benjamin H. Mullish and Arjuna Singanayagam and Vishal C. Patel and Mark R. Thursz and Unknown and Gavin Wright and Manuel Jasper and Tahir Khan and Syeda Amber Ali and Sarah Fairclough and Bushena Miyesa and Michael Villaruel and Princess Gabiana and Keval Naik and Caroline Fox and Miranda Forsey and Prem Karthikeyan and Jennifer Child and Yvonne Lester and Gautham Appanna and Hannah Donnelly and Alice Lagnado and Robbie Adamson and Joanne Elliot and Gifthy Perez and Rose Fyfe-Beedell and Siby Varghese and Chiaki Shioi and Bindu Mary Jinesh and Shannah O’Sullivan and Hannah Whitehouse and Eunice Akintemi and Matthew Cramp and Glen Marsh and Angela Downing and Gabriella Smallwood and Sasa Topol and Nelly Imbwana and Natasha Wilmshurst and Kelly Bowers and Elanor Haughan and Steven Masson and Juliet Obhiozele and Sarah Hogg and Sheenu Thomas and Lynsey Corless and George Abouda and Kim Dearnley and Jane Rice and Lisa Burton and Julie Gracie and Angie Good and Amy Hicks and Ali Elgadari and Nurun Tania and Ani Kingsbury and Mark McPhail and Michael Ihimekpen and Ruairi Lynch and Damien Leith and Jude Wellens-Mensah and Ann Elliott and Leanne Cosgrove and Abigail Grieve and Paul Johnson and Dina Mansour and Rajan Bhandari and Ann Wilson and Dorothy Carman and Kara Wilshire and Rachael Swann and Laura Davidson and Michael Lumsden and Keziah Lewis and Dominic Rimmer and Faye McMeeken and Shona Perry and Nicole Stoddart and Kirsty Fallon and Lesley Gilmour and Hayley King and Deborah McGlynn and Katherine Burrows and Gemma Duff and Lauren Walker and Alexis Duncan and Guru Aithal and Robert Scott and Adina Olaru and Kimberley Noon and Sophie Cusick and Maria Baffa-Scineli and Amanda Cetroni and Sebastian Wallace and Clare Bradley and Salman Bhatta and Euan Humphreys and Fiona Barrett and Charlotte Barr and Andy Gibson and Valarie Anderson and Safa Al-Shamma and Lindsay Rogers and Fardowsa Ahmed-Timms and Annamaria Wilce and Nicholas Taylor and Andrew Austin and Claire Grant and Maggie Langley and Catherine Addleton and Jisha Joseph and Zeino Zeino and Ankur Srivastava and James Maurice and Lana Ward and Trudie Burge and Louise Jennings and Joseph Delo and Joana Teixeira and Criscel Jan Pelaez and Maria Belini and Amy Curtis and Annie Matthew and Samantha Taylor and Valentia Raspa and Khine Thu and Caroline Gosson and Victoria Comerford and Oluwadamilola Ogunrinde and Kim Sorley and Simon O’ Sullivan and Ian Rowe and Oliver Tavabie and Suzannah Dorey and Arshatisha Joe and Rebecca Bishop and Mehvish Hussain and Yasira Ghaseeta and Madeleine Graydon and Jonathan King and Gareth Hahn and Celia Diaz-Moore and James Neale and Pauline Mercer and Claire Stringer and Sophie Booth and Natasha McDonald and Emma Speake and Rebecca Rielly and Morag Murray and Maria McLaughlin and Sandra Newlands and Janisha Patel and Sofia Pires and Susan Samuel and Faith Panilagao-Bushi and Simon D. Goldenberg and Ben Carter and Lindsey A. Edwards and Debbie L. Shawcross},
  year = {2026},
  journal = {Trials},
  doi = {10.1186/s13063-026-09914-x},
  url = {https://doi.org/10.1186/s13063-026-09914-x}
}

RIS

TY  - JOUR
TI  - PROMISE: a PROspective randomised double-blind parallel group placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis over 24 months—study protocol for a clinical trial
AU  - Victoria T. Kronsten
AU  - Yevedzo Ntuli
AU  - Ellis Kobina Paintsil
AU  - Charlotte A. Woodhouse
AU  - Thomas H. Tranah
AU  - Sue Cheung
AU  - Daryl Hagan
AU  - Blair Merrick
AU  - Angela Cape
AU  - Francesca Maher
AU  - Kirin Sultana
AU  - Desiree Prossomariti
AU  - Steven Rodrigues
AU  - Christine Masterson
AU  - Vanessa Hebditch
AU  - Ane Zamalloa
AU  - Benjamin H. Mullish
AU  - Arjuna Singanayagam
AU  - Vishal C. Patel
AU  - Mark R. Thursz
AU  - Unknown
AU  - Gavin Wright
AU  - Manuel Jasper
AU  - Tahir Khan
AU  - Syeda Amber Ali
AU  - Sarah Fairclough
AU  - Bushena Miyesa
AU  - Michael Villaruel
AU  - Princess Gabiana
AU  - Keval Naik
AU  - Caroline Fox
AU  - Miranda Forsey
AU  - Prem Karthikeyan
AU  - Jennifer Child
AU  - Yvonne Lester
AU  - Gautham Appanna
AU  - Hannah Donnelly
AU  - Alice Lagnado
AU  - Robbie Adamson
AU  - Joanne Elliot
AU  - Gifthy Perez
AU  - Rose Fyfe-Beedell
AU  - Siby Varghese
AU  - Chiaki Shioi
AU  - Bindu Mary Jinesh
AU  - Shannah O’Sullivan
AU  - Hannah Whitehouse
AU  - Eunice Akintemi
AU  - Matthew Cramp
AU  - Glen Marsh
AU  - Angela Downing
AU  - Gabriella Smallwood
AU  - Sasa Topol
AU  - Nelly Imbwana
AU  - Natasha Wilmshurst
AU  - Kelly Bowers
AU  - Elanor Haughan
AU  - Steven Masson
AU  - Juliet Obhiozele
AU  - Sarah Hogg
AU  - Sheenu Thomas
AU  - Lynsey Corless
AU  - George Abouda
AU  - Kim Dearnley
AU  - Jane Rice
AU  - Lisa Burton
AU  - Julie Gracie
AU  - Angie Good
AU  - Amy Hicks
AU  - Ali Elgadari
AU  - Nurun Tania
AU  - Ani Kingsbury
AU  - Mark McPhail
AU  - Michael Ihimekpen
AU  - Ruairi Lynch
AU  - Damien Leith
AU  - Jude Wellens-Mensah
AU  - Ann Elliott
AU  - Leanne Cosgrove
AU  - Abigail Grieve
AU  - Paul Johnson
AU  - Dina Mansour
AU  - Rajan Bhandari
AU  - Ann Wilson
AU  - Dorothy Carman
AU  - Kara Wilshire
AU  - Rachael Swann
AU  - Laura Davidson
AU  - Michael Lumsden
AU  - Keziah Lewis
AU  - Dominic Rimmer
AU  - Faye McMeeken
AU  - Shona Perry
AU  - Nicole Stoddart
AU  - Kirsty Fallon
AU  - Lesley Gilmour
AU  - Hayley King
AU  - Deborah McGlynn
AU  - Katherine Burrows
AU  - Gemma Duff
AU  - Lauren Walker
AU  - Alexis Duncan
AU  - Guru Aithal
AU  - Robert Scott
AU  - Adina Olaru
AU  - Kimberley Noon
AU  - Sophie Cusick
AU  - Maria Baffa-Scineli
AU  - Amanda Cetroni
AU  - Sebastian Wallace
AU  - Clare Bradley
AU  - Salman Bhatta
AU  - Euan Humphreys
AU  - Fiona Barrett
AU  - Charlotte Barr
AU  - Andy Gibson
AU  - Valarie Anderson
AU  - Safa Al-Shamma
AU  - Lindsay Rogers
AU  - Fardowsa Ahmed-Timms
AU  - Annamaria Wilce
AU  - Nicholas Taylor
AU  - Andrew Austin
AU  - Claire Grant
AU  - Maggie Langley
AU  - Catherine Addleton
AU  - Jisha Joseph
AU  - Zeino Zeino
AU  - Ankur Srivastava
AU  - James Maurice
AU  - Lana Ward
AU  - Trudie Burge
AU  - Louise Jennings
AU  - Joseph Delo
AU  - Joana Teixeira
AU  - Criscel Jan Pelaez
AU  - Maria Belini
AU  - Amy Curtis
AU  - Annie Matthew
AU  - Samantha Taylor
AU  - Valentia Raspa
AU  - Khine Thu
AU  - Caroline Gosson
AU  - Victoria Comerford
AU  - Oluwadamilola Ogunrinde
AU  - Kim Sorley
AU  - Simon O’ Sullivan
AU  - Ian Rowe
AU  - Oliver Tavabie
AU  - Suzannah Dorey
AU  - Arshatisha Joe
AU  - Rebecca Bishop
AU  - Mehvish Hussain
AU  - Yasira Ghaseeta
AU  - Madeleine Graydon
AU  - Jonathan King
AU  - Gareth Hahn
AU  - Celia Diaz-Moore
AU  - James Neale
AU  - Pauline Mercer
AU  - Claire Stringer
AU  - Sophie Booth
AU  - Natasha McDonald
AU  - Emma Speake
AU  - Rebecca Rielly
AU  - Morag Murray
AU  - Maria McLaughlin
AU  - Sandra Newlands
AU  - Janisha Patel
AU  - Sofia Pires
AU  - Susan Samuel
AU  - Faith Panilagao-Bushi
AU  - Simon D. Goldenberg
AU  - Ben Carter
AU  - Lindsey A. Edwards
AU  - Debbie L. Shawcross
PY  - 2026
JO  - Trials
DO  - 10.1186/s13063-026-09914-x
UR  - https://doi.org/10.1186/s13063-026-09914-x
ER  -

APA

Kronsten, V. T., Ntuli, Y., Paintsil, E. K., Woodhouse, C. A., Tranah, T. H., Cheung, S., Hagan, D., Merrick, B., Cape, A., Maher, F., Sultana, K., Prossomariti, D., Rodrigues, S., Masterson, C., Hebditch, V., Zamalloa, A., Mullish, B. H., Singanayagam, A., Patel, V. C., Thursz, M. R., Unknown, Wright, G., Jasper, M., Khan, T., Ali, S. A., Fairclough, S., Miyesa, B., Villaruel, M., Gabiana, P., Naik, K., Fox, C., Forsey, M., Karthikeyan, P., Child, J., Lester, Y., Appanna, G., Donnelly, H., Lagnado, A., Adamson, R., Elliot, J., Perez, G., Fyfe-Beedell, R., Varghese, S., Shioi, C., Jinesh, B. M., O’Sullivan, S., Whitehouse, H., Akintemi, E., Cramp, M., Marsh, G., Downing, A., Smallwood, G., Topol, S., Imbwana, N., Wilmshurst, N., Bowers, K., Haughan, E., Masson, S., Obhiozele, J., Hogg, S., Thomas, S., Corless, L., Abouda, G., Dearnley, K., Rice, J., Burton, L., Gracie, J., Good, A., Hicks, A., Elgadari, A., Tania, N., Kingsbury, A., McPhail, M., Ihimekpen, M., Lynch, R., Leith, D., Wellens-Mensah, J., Elliott, A., Cosgrove, L., Grieve, A., Johnson, P., Mansour, D., Bhandari, R., Wilson, A., Carman, D., Wilshire, K., Swann, R., Davidson, L., Lumsden, M., Lewis, K., Rimmer, D., McMeeken, F., Perry, S., Stoddart, N., Fallon, K., Gilmour, L., King, H., McGlynn, D., Burrows, K., Duff, G., Walker, L., Duncan, A., Aithal, G., Scott, R., Olaru, A., Noon, K., Cusick, S., Baffa-Scineli, M., Cetroni, A., Wallace, S., Bradley, C., Bhatta, S., Humphreys, E., Barrett, F., Barr, C., Gibson, A., Anderson, V., Al-Shamma, S., Rogers, L., Ahmed-Timms, F., Wilce, A., Taylor, N., Austin, A., Grant, C., Langley, M., Addleton, C., Joseph, J., Zeino, Z., Srivastava, A., Maurice, J., Ward, L., Burge, T., Jennings, L., Delo, J., Teixeira, J., Pelaez, C. J., Belini, M., Curtis, A., Matthew, A., Taylor, S., Raspa, V., Thu, K., Gosson, C., Comerford, V., Ogunrinde, O., Sorley, K., Sullivan, S. O., Rowe, I., Tavabie, O., Dorey, S., Joe, A., Bishop, R., Hussain, M., Ghaseeta, Y., Graydon, M., King, J., Hahn, G., Diaz-Moore, C., Neale, J., Mercer, P., Stringer, C., Booth, S., McDonald, N., Speake, E., Rielly, R., Murray, M., McLaughlin, M., Newlands, S., Patel, J., Pires, S., Samuel, S., Panilagao-Bushi, F., Goldenberg, S. D., Carter, B., Edwards, L. A., & Shawcross, D. L. (2026). PROMISE: a PROspective randomised double-blind parallel group placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis over 24 months—study protocol for a clinical trial. Trials. https://doi.org/10.1186/s13063-026-09914-x

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crossref · retrieved 2026-11-10T14:27:36.184Z