Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).

Palleis C, Weidinger E, Maaß S, Linke M, Brendel M, Stöcklein S, Al Tawil A, Mansmann U, Teupser D, Borst T, Heimke-Brinck R, Hemmer B, Höglinger GU, Bidner H, Simons M, Levin J

Open source

DOI: 10.1186/s42466-026-00504-5
Published: 2026 Jul 3
Container: Neurological research and practice
Publisher: Not recorded
Open access: yes

Credibility signals

uncertain Score 53/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
supportingDirectory of Open Access Journals: A matching record was returned by DOAJ. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1186/s42466-026-00504-5,
  title = {Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).},
  author = {Palleis C and Weidinger E and Maaß S and Linke M and Brendel M and Stöcklein S and Al Tawil A and Mansmann U and Teupser D and Borst T and Heimke-Brinck R and Hemmer B and Höglinger GU and Bidner H and Simons M and Levin J},
  year = {2026},
  journal = {Neurological research and practice},
  doi = {10.1186/s42466-026-00504-5},
  url = {https://doi.org/10.1186/s42466-026-00504-5}
}

RIS

TY  - JOUR
TI  - Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).
AU  - Palleis C
AU  - Weidinger E
AU  - Maaß S
AU  - Linke M
AU  - Brendel M
AU  - Stöcklein S
AU  - Al Tawil A
AU  - Mansmann U
AU  - Teupser D
AU  - Borst T
AU  - Heimke-Brinck R
AU  - Hemmer B
AU  - Höglinger GU
AU  - Bidner H
AU  - Simons M
AU  - Levin J
PY  - 2026
JO  - Neurological research and practice
DO  - 10.1186/s42466-026-00504-5
UR  - https://doi.org/10.1186/s42466-026-00504-5
ER  -

APA

C, P., E, W., S, M., M, L., M, B., S, S., A, A. T., U, M., D, T., T, B., R, H., B, H., GU, H., H, B., M, S., & J, L. (2026). Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).. Neurological research and practice. https://doi.org/10.1186/s42466-026-00504-5

Source records

pubmed · retrieved 2026-09-25T20:10:43.241Z
europe-pmc · retrieved 2026-09-25T20:10:43.254Z
doaj · retrieved 2026-09-25T20:10:43.258Z