Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Nigussie T. Sharew, Scott R. Clark, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Janice M. Fullerton, Liping Hou, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Fasil Tekola-Ayele, Carla Gallo, Roland Hasler, Hélène Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh K. Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceana, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno Étain, Stéphane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba O. Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef E. Dietrich, Christian Figge, Markus Jäger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauß, Andrea Schmitt, Carsten Spitzer, Martin Von Hagen, Jens Wiltfang, Jörg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cüneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffman, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Novak, Claire O’Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andrea Reif, Eva Reininghaus, Guy A. Rouleau, Janus K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Biju Viswanath, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Bernhard T. Baune, K. Oliver Schubert, Azmeraw T. Amare

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DOI
10.1192/bjp.2026.10776
Published
2026-10-07
Container
The British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Open access
unknown

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BibTeX

@article{allodium:10.1192/bjp.2026.10776,
  title = {Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder},
  author = {Nigussie T. Sharew and Scott R. Clark and Simon Hartmann and Sergi Papiol and Urs Heilbronner and Franziska Degenhardt and Janice M. Fullerton and Liping Hou and Tatyana Shekhtman and Mazda Adli and Nirmala Akula and Kazufumi Akiyama and Raffaella Ardau and Bárbara Arias and Fasil Tekola-Ayele and Carla Gallo and Roland Hasler and Hélène Richard-Lepouriel and Nader Perroud and Lena Backlund and Abesh K. Bhattacharjee and Frank Bellivier and Antonio Benabarre and Susanne Bengesser and Joanna M. Biernacka and Armin Birner and Cynthia Marie-Claire and Pablo Cervantes and Hsi-Chung Chen and Caterina Chillotti and Sven Cichon and Cristiana Cruceana and Piotr M. Czerski and Nina Dalkner and Maria Del Zompo and J. Raymond DePaulo and Bruno Étain and Stéphane Jamain and Peter Falkai and Andreas J. Forstner and Louise Frisen and Mark A. Frye and Sebastien Gard and Julie S. Garnham and Fernando S. Goes and Maria Grigoroiu-Serbanescu and Andreas J. Fallgatter and Sophia Stegmaier and Thomas Ethofer and Silvia Biere and Kristiyana Petrova and Ceylan Schuster and Kristina Adorjan and Monika Budde and Maria Heilbronner and Janos L. Kalman and Mojtaba O. Kohshour and Daniela Reich-Erkelenz and Sabrina K. Schaupp and Eva C. Schulte and Fanny Senner and Thomas Vogl and Ion-George Anghelescu and Volker Arolt and Udo Dannlowski and Detlef E. Dietrich and Christian Figge and Markus Jäger and Fabian U. Lang and Georg Juckel and Carsten Konrad and Jens Reimer and Max Schmauß and Andrea Schmitt and Carsten Spitzer and Martin Von Hagen and Jens Wiltfang and Jörg Zimmermann and Till F. M. Andlauer and Andre Fischer and Felix Bermpohl and Philipp Ritter and Silke Matura and Anna Gryaznova and Irina Falkenberg and Cüneyt Yildiz and Tilo Kircher and Julia Schmidt and Marius Koch and Kathrin Gade and Sarah Trost and Ida S. Haussleiter and Martin Lambert and Anja C. Rohenkohl and Vivien Kraft and Paul Grof and Ryota Hashimoto and Joanna Hauser and Stefan Herms and Per Hoffman and Esther Jiménez and Jean-Pierre Kahn and Layla Kassem and Po-Hsiu Kuo and Tadafumi Kato and John Kelsoe and Sarah Kittel-Schneider and Ewa Ferensztajn-Rochowiak and Barbara König and Ichiro Kusumi and Gonzalo Laje and Mikael Landén and Catharina Lavebratt and Marion Leboyer and Susan G. Leckband and Alfonso Tortorella and Mirko Manchia and Lina Martinsson and Michael J. McCarthy and Susan L. McElroy and Francesc Colom and Vincent Millischer and Marina Mitjans and Francis M. Mondimore and Palmiero Monteleone and Caroline M. Nievergelt and Markus M. Nöthen and Tomas Novak and Claire O’Donovan and Norio Ozaki and Andrea Pfennig and Claudia Pisanu and James B. Potash and Andrea Reif and Eva Reininghaus and Guy A. Rouleau and Janus K. Rybakowski and Martin Schalling and Peter R. Schofield and Barbara W. Schweizer and Giovanni Severino and Paul D. Shilling and Katzutaka Shimoda and Christian Simhandl and Claire M. Slaney and Alessio Squassina and Thomas Stamm and Pavla Stopkova and Mario Maj and Gustavo Turecki and Eduard Vieta and Julia Veeh and Biju Viswanath and Stephanie H. Witt and Adam Wright and Peter P. Zandi and Philip B. Mitchell and Michael Bauer and Martin Alda and Marcella Rietschel and Francis J. McMahon and Thomas G. Schulze and Bernhard T. Baune and K. Oliver Schubert and Azmeraw T. Amare},
  year = {2026},
  journal = {The British Journal of Psychiatry},
  doi = {10.1192/bjp.2026.10776},
  url = {https://doi.org/10.1192/bjp.2026.10776}
}

RIS

TY  - JOUR
TI  - Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder
AU  - Nigussie T. Sharew
AU  - Scott R. Clark
AU  - Simon Hartmann
AU  - Sergi Papiol
AU  - Urs Heilbronner
AU  - Franziska Degenhardt
AU  - Janice M. Fullerton
AU  - Liping Hou
AU  - Tatyana Shekhtman
AU  - Mazda Adli
AU  - Nirmala Akula
AU  - Kazufumi Akiyama
AU  - Raffaella Ardau
AU  - Bárbara Arias
AU  - Fasil Tekola-Ayele
AU  - Carla Gallo
AU  - Roland Hasler
AU  - Hélène Richard-Lepouriel
AU  - Nader Perroud
AU  - Lena Backlund
AU  - Abesh K. Bhattacharjee
AU  - Frank Bellivier
AU  - Antonio Benabarre
AU  - Susanne Bengesser
AU  - Joanna M. Biernacka
AU  - Armin Birner
AU  - Cynthia Marie-Claire
AU  - Pablo Cervantes
AU  - Hsi-Chung Chen
AU  - Caterina Chillotti
AU  - Sven Cichon
AU  - Cristiana Cruceana
AU  - Piotr M. Czerski
AU  - Nina Dalkner
AU  - Maria Del Zompo
AU  - J. Raymond DePaulo
AU  - Bruno Étain
AU  - Stéphane Jamain
AU  - Peter Falkai
AU  - Andreas J. Forstner
AU  - Louise Frisen
AU  - Mark A. Frye
AU  - Sebastien Gard
AU  - Julie S. Garnham
AU  - Fernando S. Goes
AU  - Maria Grigoroiu-Serbanescu
AU  - Andreas J. Fallgatter
AU  - Sophia Stegmaier
AU  - Thomas Ethofer
AU  - Silvia Biere
AU  - Kristiyana Petrova
AU  - Ceylan Schuster
AU  - Kristina Adorjan
AU  - Monika Budde
AU  - Maria Heilbronner
AU  - Janos L. Kalman
AU  - Mojtaba O. Kohshour
AU  - Daniela Reich-Erkelenz
AU  - Sabrina K. Schaupp
AU  - Eva C. Schulte
AU  - Fanny Senner
AU  - Thomas Vogl
AU  - Ion-George Anghelescu
AU  - Volker Arolt
AU  - Udo Dannlowski
AU  - Detlef E. Dietrich
AU  - Christian Figge
AU  - Markus Jäger
AU  - Fabian U. Lang
AU  - Georg Juckel
AU  - Carsten Konrad
AU  - Jens Reimer
AU  - Max Schmauß
AU  - Andrea Schmitt
AU  - Carsten Spitzer
AU  - Martin Von Hagen
AU  - Jens Wiltfang
AU  - Jörg Zimmermann
AU  - Till F. M. Andlauer
AU  - Andre Fischer
AU  - Felix Bermpohl
AU  - Philipp Ritter
AU  - Silke Matura
AU  - Anna Gryaznova
AU  - Irina Falkenberg
AU  - Cüneyt Yildiz
AU  - Tilo Kircher
AU  - Julia Schmidt
AU  - Marius Koch
AU  - Kathrin Gade
AU  - Sarah Trost
AU  - Ida S. Haussleiter
AU  - Martin Lambert
AU  - Anja C. Rohenkohl
AU  - Vivien Kraft
AU  - Paul Grof
AU  - Ryota Hashimoto
AU  - Joanna Hauser
AU  - Stefan Herms
AU  - Per Hoffman
AU  - Esther Jiménez
AU  - Jean-Pierre Kahn
AU  - Layla Kassem
AU  - Po-Hsiu Kuo
AU  - Tadafumi Kato
AU  - John Kelsoe
AU  - Sarah Kittel-Schneider
AU  - Ewa Ferensztajn-Rochowiak
AU  - Barbara König
AU  - Ichiro Kusumi
AU  - Gonzalo Laje
AU  - Mikael Landén
AU  - Catharina Lavebratt
AU  - Marion Leboyer
AU  - Susan G. Leckband
AU  - Alfonso Tortorella
AU  - Mirko Manchia
AU  - Lina Martinsson
AU  - Michael J. McCarthy
AU  - Susan L. McElroy
AU  - Francesc Colom
AU  - Vincent Millischer
AU  - Marina Mitjans
AU  - Francis M. Mondimore
AU  - Palmiero Monteleone
AU  - Caroline M. Nievergelt
AU  - Markus M. Nöthen
AU  - Tomas Novak
AU  - Claire O’Donovan
AU  - Norio Ozaki
AU  - Andrea Pfennig
AU  - Claudia Pisanu
AU  - James B. Potash
AU  - Andrea Reif
AU  - Eva Reininghaus
AU  - Guy A. Rouleau
AU  - Janus K. Rybakowski
AU  - Martin Schalling
AU  - Peter R. Schofield
AU  - Barbara W. Schweizer
AU  - Giovanni Severino
AU  - Paul D. Shilling
AU  - Katzutaka Shimoda
AU  - Christian Simhandl
AU  - Claire M. Slaney
AU  - Alessio Squassina
AU  - Thomas Stamm
AU  - Pavla Stopkova
AU  - Mario Maj
AU  - Gustavo Turecki
AU  - Eduard Vieta
AU  - Julia Veeh
AU  - Biju Viswanath
AU  - Stephanie H. Witt
AU  - Adam Wright
AU  - Peter P. Zandi
AU  - Philip B. Mitchell
AU  - Michael Bauer
AU  - Martin Alda
AU  - Marcella Rietschel
AU  - Francis J. McMahon
AU  - Thomas G. Schulze
AU  - Bernhard T. Baune
AU  - K. Oliver Schubert
AU  - Azmeraw T. Amare
PY  - 2026
JO  - The British Journal of Psychiatry
DO  - 10.1192/bjp.2026.10776
UR  - https://doi.org/10.1192/bjp.2026.10776
ER  -

APA

Sharew, N. T., Clark, S. R., Hartmann, S., Papiol, S., Heilbronner, U., Degenhardt, F., Fullerton, J. M., Hou, L., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Tekola-Ayele, F., Gallo, C., Hasler, R., Richard-Lepouriel, H., Perroud, N., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Marie-Claire, C., Cervantes, P., Chen, H., Chillotti, C., Cichon, S., Cruceana, C., Czerski, P. M., Dalkner, N., Zompo, M. D., DePaulo, J. R., Étain, B., Jamain, S., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Fallgatter, A. J., Stegmaier, S., Ethofer, T., Biere, S., Petrova, K., Schuster, C., Adorjan, K., Budde, M., Heilbronner, M., Kalman, J. L., Kohshour, M. O., Reich-Erkelenz, D., Schaupp, S. K., Schulte, E. C., Senner, F., Vogl, T., Anghelescu, I., Arolt, V., Dannlowski, U., Dietrich, D. E., Figge, C., Jäger, M., Lang, F. U., Juckel, G., Konrad, C., Reimer, J., Schmauß, M., Schmitt, A., Spitzer, C., Hagen, M. V., Wiltfang, J., Zimmermann, J., Andlauer, T. F. M., Fischer, A., Bermpohl, F., Ritter, P., Matura, S., Gryaznova, A., Falkenberg, I., Yildiz, C., Kircher, T., Schmidt, J., Koch, M., Gade, K., Trost, S., Haussleiter, I. S., Lambert, M., Rohenkohl, A. C., Kraft, V., Grof, P., Hashimoto, R., Hauser, J., Herms, S., Hoffman, P., Jiménez, E., Kahn, J., Kassem, L., Kuo, P., Kato, T., Kelsoe, J., Kittel-Schneider, S., Ferensztajn-Rochowiak, E., König, B., Kusumi, I., Laje, G., Landén, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Tortorella, A., Manchia, M., Martinsson, L., McCarthy, M. J., McElroy, S. L., Colom, F., Millischer, V., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nöthen, M. M., Novak, T., O’Donovan, C., Ozaki, N., Pfennig, A., Pisanu, C., Potash, J. B., Reif, A., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T., Stopkova, P., Maj, M., Turecki, G., Vieta, E., Veeh, J., Viswanath, B., Witt, S. H., Wright, A., Zandi, P. P., Mitchell, P. B., Bauer, M., Alda, M., Rietschel, M., McMahon, F. J., Schulze, T. G., Baune, B. T., Schubert, K. O., & Amare, A. T. (2026). Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder. The British Journal of Psychiatry. https://doi.org/10.1192/bjp.2026.10776

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