Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study

Kohei Shitara, Sylvie Lorenzen, Jin Li, Yuxian Bai, Manuel González Fernández, Mynor Aguilar, Hirokazu Shoji, Felipe Reyes-Cosmelli, Yovany Rodriguez Peña, Luis Corrales, Lucjan Wyrwicz, Daniel Acosta Eyzaguirre, Yueyin Pan, Min-Hee Ryu, Deirdre J. Cohen, Zev A. Wainberg, Geoffrey Ku, Josep Tabernero, Eric Van Cutsem, Shu-Kui Qin, Do-Youn Oh, Jianming Xu, Li Wen Liang, Sonal Bordia, Pooja Bhagia, Sun Young Rha, Unknown, Ezequiel Heman Slutsky, Juan Cundom, Andrea Gabriela Soria, Marcela Alejandro Carballido, Juan Manuel O'Connor, Julieta Grasseli, Matthew Burge, Daniel Paul Brungs, Muhammad Adnan Khattak, Karen Paula Jozefa Geboes, Eric Van Cutsem, Jeroen Dekervel, Lionel D. Hondt, Frederic Lemay, Rosalyn Anne Juergens, Felipe Reyes, Gonzalo Pizarro Brito, Maria Alejandra Ojeda, Herman Adolfo Araya, Patricio Eduardo Yanez, Jianwei Yang, Xi Chen, Yuxian Bai, Hongming Pan, Nong Xu, Yueyin Pan, Qinghong Guo, Baorui Liu, Feng Ye, Xin Wang, Qi Li, Yong Tang, Huiting Xu, Haichuan Su, Ying Cheng, Xianli Yin, Qun Zhao, Ning Li, Jun You, Yi Ba, Jinsheng We, Lin Shen, Jin Li, Wangjun Liao, Zhen Li, Lei Yang, Yovany Eduardo Rodriguez Pena, Ivan Jose Bustillo, Carlos Jose Narvaez, Manuel Enrique Gonzalez Fernandez, Raimundo Manneh, Andres Fernando Arenas Arias, Luis Corrales, Andres Wiernik Rodriguez, Thomas Aparicio, Yuan Touchefeu, Helene Boussion-Desloges, Laurent Mineur, Christophe Tournigand, Francois Ghiringhelli, Marie Pierre Galais, Eric Terrebonne, Thomas Walter, Mathieu Baconnier, Sylvie Lorenzen, Eray Goekkurt, Annika Kurreck, Arne Kandulski, Thorsten Goetze, Florian Lordick, Mynor Aguilar, Karla Alejandra Lopez, Rixci Augusto Lenin Ramirez Fallas, Pier Anyelo Ramos Elias, Juan Pablo Moreira, Wing Lok Wendy Chan, Ashely Cheng, Winnie Yeo, Maeve Lowery, Adrian Murphy, Sharon Pelles Avraham, Ayala Hubert, Irit Ben-Aharon, Valeriya Semenisty, Gali Perl, Wael Hozaeel, Armando Santoro, Elena Aurelia Mazza, Ferdinando de Vita, Guiseppe Aprile, Giovanni Gerardo Cardellino, Filippo Pietrantonio, Pierfrancesco Tassone, Kohei Shitara, Hirokazu Shoji, Yukiya Narita, Hiroki Hara, Kensei Yamaguchi, Naotoshi Sugimoto, Nozomu Machida, Tomohiro Nishina, Akihito Tsuji, Yasuhiro Choda, Kenji Amagai, Masahiro Tsuda, Shogen Boku, Boguslawa Karaszewska, Kamil Stanislaw Kuc, Jacek Mackiewicz, Lucjan Stanislaw Wyrwicz, Lukasz Hajac, Alexy Alexandrovich Tryakin, Dmitry Aleksandrovich Nosov, Rashida Orlova, Alexey Mikhailovich Karachun, Michael Osipov, Mikhail Valerievich Kopp, Natalia Vladimirovna Fadeeva, Nikolay Viktorovich Kislov, Sun Young Rha, Seung Tae Kim, Min-Hee Ryu, Do-Youn Oh, Keun-Wook Lee, Hei-Cheul Jeung, Jonggwon Choi, Sang Cheul Oh, Paula Jimenez Fonseca, Fernando Rivera Herrero, Pilar Aitana Calvo Ferrandiz, Daniel Acosta Eyzaguirre, Kun-Huei Yeh, Jen-Shi Chen, Li-Yuan Bai, Chia-Jui Yen, Bulent Erdogan, Pinar Gursoy, Mustafa Ozguroglu, Suayib Yalcin, Umut Demirci, Mehmet Bilici, Ilhan Hacibekiroglu, Hugo Ford, Kai-Keen Shiu, Martin Scott-Brown, Russell Petty, Wasat Mansoor, Zev A. Wainberg, Marcus Noel, Peter Enzinger, Sreenivasa Chandana, Geoffrey Ku, Dierdre Cohen, Vincent Lam

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DOI: 10.1200/jco-25-00748
Published: 2025-08
Container: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1200/jco-25-00748,
  title = {Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study},
  author = {Kohei Shitara and Sylvie Lorenzen and Jin Li and Yuxian Bai and Manuel González Fernández and Mynor Aguilar and Hirokazu Shoji and Felipe Reyes-Cosmelli and Yovany Rodriguez Peña and Luis Corrales and Lucjan Wyrwicz and Daniel Acosta Eyzaguirre and Yueyin Pan and Min-Hee Ryu and Deirdre J. Cohen and Zev A. Wainberg and Geoffrey Ku and Josep Tabernero and Eric Van Cutsem and Shu-Kui Qin and Do-Youn Oh and Jianming Xu and Li Wen Liang and Sonal Bordia and Pooja Bhagia and Sun Young Rha and Unknown and Ezequiel Heman Slutsky and Juan Cundom and Andrea Gabriela Soria and Marcela Alejandro Carballido and Juan Manuel O'Connor and Julieta Grasseli and Matthew Burge and Daniel Paul Brungs and Muhammad Adnan Khattak and Karen Paula Jozefa Geboes and Eric Van Cutsem and Jeroen Dekervel and Lionel D. Hondt and Frederic Lemay and Rosalyn Anne Juergens and Felipe Reyes and Gonzalo Pizarro Brito and Maria Alejandra Ojeda and Herman Adolfo Araya and Patricio Eduardo Yanez and Jianwei Yang and Xi Chen and Yuxian Bai and Hongming Pan and Nong Xu and Yueyin Pan and Qinghong Guo and Baorui Liu and Feng Ye and Xin Wang and Qi Li and Yong Tang and Huiting Xu and Haichuan Su and Ying Cheng and Xianli Yin and Qun Zhao and Ning Li and Jun You and Yi Ba and Jinsheng We and Lin Shen and Jin Li and Wangjun Liao and Zhen Li and Lei Yang and Yovany Eduardo Rodriguez Pena and Ivan Jose Bustillo and Carlos Jose Narvaez and Manuel Enrique Gonzalez Fernandez and Raimundo Manneh and Andres Fernando Arenas Arias and Luis Corrales and Andres Wiernik Rodriguez and Thomas Aparicio and Yuan Touchefeu and Helene Boussion-Desloges and Laurent Mineur and Christophe Tournigand and Francois Ghiringhelli and Marie Pierre Galais and Eric Terrebonne and Thomas Walter and Mathieu Baconnier and Sylvie Lorenzen and Eray Goekkurt and Annika Kurreck and Arne Kandulski and Thorsten Goetze and Florian Lordick and Mynor Aguilar and Karla Alejandra Lopez and Rixci Augusto Lenin Ramirez Fallas and Pier Anyelo Ramos Elias and Juan Pablo Moreira and Wing Lok Wendy Chan and Ashely Cheng and Winnie Yeo and Maeve Lowery and Adrian Murphy and Sharon Pelles Avraham and Ayala Hubert and Irit Ben-Aharon and Valeriya Semenisty and Gali Perl and Wael Hozaeel and Armando Santoro and Elena Aurelia Mazza and Ferdinando de Vita and Guiseppe Aprile and Giovanni Gerardo Cardellino and Filippo Pietrantonio and Pierfrancesco Tassone and Kohei Shitara and Hirokazu Shoji and Yukiya Narita and Hiroki Hara and Kensei Yamaguchi and Naotoshi Sugimoto and Nozomu Machida and Tomohiro Nishina and Akihito Tsuji and Yasuhiro Choda and Kenji Amagai and Masahiro Tsuda and Shogen Boku and Boguslawa Karaszewska and Kamil Stanislaw Kuc and Jacek Mackiewicz and Lucjan Stanislaw Wyrwicz and Lukasz Hajac and Alexy Alexandrovich Tryakin and Dmitry Aleksandrovich Nosov and Rashida Orlova and Alexey Mikhailovich Karachun and Michael Osipov and Mikhail Valerievich Kopp and Natalia Vladimirovna Fadeeva and Nikolay Viktorovich Kislov and Sun Young Rha and Seung Tae Kim and Min-Hee Ryu and Do-Youn Oh and Keun-Wook Lee and Hei-Cheul Jeung and Jonggwon Choi and Sang Cheul Oh and Paula Jimenez Fonseca and Fernando Rivera Herrero and Pilar Aitana Calvo Ferrandiz and Daniel Acosta Eyzaguirre and Kun-Huei Yeh and Jen-Shi Chen and Li-Yuan Bai and Chia-Jui Yen and Bulent Erdogan and Pinar Gursoy and Mustafa Ozguroglu and Suayib Yalcin and Umut Demirci and Mehmet Bilici and Ilhan Hacibekiroglu and Hugo Ford and Kai-Keen Shiu and Martin Scott-Brown and Russell Petty and Wasat Mansoor and Zev A. Wainberg and Marcus Noel and Peter Enzinger and Sreenivasa Chandana and Geoffrey Ku and Dierdre Cohen and Vincent Lam},
  year = {2025},
  journal = {Journal of Clinical Oncology},
  doi = {10.1200/jco-25-00748},
  url = {https://doi.org/10.1200/jco-25-00748}
}

RIS

TY  - JOUR
TI  - Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study
AU  - Kohei Shitara
AU  - Sylvie Lorenzen
AU  - Jin Li
AU  - Yuxian Bai
AU  - Manuel González Fernández
AU  - Mynor Aguilar
AU  - Hirokazu Shoji
AU  - Felipe Reyes-Cosmelli
AU  - Yovany Rodriguez Peña
AU  - Luis Corrales
AU  - Lucjan Wyrwicz
AU  - Daniel Acosta Eyzaguirre
AU  - Yueyin Pan
AU  - Min-Hee Ryu
AU  - Deirdre J. Cohen
AU  - Zev A. Wainberg
AU  - Geoffrey Ku
AU  - Josep Tabernero
AU  - Eric Van Cutsem
AU  - Shu-Kui Qin
AU  - Do-Youn Oh
AU  - Jianming Xu
AU  - Li Wen Liang
AU  - Sonal Bordia
AU  - Pooja Bhagia
AU  - Sun Young Rha
AU  - Unknown
AU  - Ezequiel Heman Slutsky
AU  - Juan Cundom
AU  - Andrea Gabriela Soria
AU  - Marcela Alejandro Carballido
AU  - Juan Manuel O'Connor
AU  - Julieta Grasseli
AU  - Matthew Burge
AU  - Daniel Paul Brungs
AU  - Muhammad Adnan Khattak
AU  - Karen Paula Jozefa Geboes
AU  - Eric Van Cutsem
AU  - Jeroen Dekervel
AU  - Lionel D. Hondt
AU  - Frederic Lemay
AU  - Rosalyn Anne Juergens
AU  - Felipe Reyes
AU  - Gonzalo Pizarro Brito
AU  - Maria Alejandra Ojeda
AU  - Herman Adolfo Araya
AU  - Patricio Eduardo Yanez
AU  - Jianwei Yang
AU  - Xi Chen
AU  - Yuxian Bai
AU  - Hongming Pan
AU  - Nong Xu
AU  - Yueyin Pan
AU  - Qinghong Guo
AU  - Baorui Liu
AU  - Feng Ye
AU  - Xin Wang
AU  - Qi Li
AU  - Yong Tang
AU  - Huiting Xu
AU  - Haichuan Su
AU  - Ying Cheng
AU  - Xianli Yin
AU  - Qun Zhao
AU  - Ning Li
AU  - Jun You
AU  - Yi Ba
AU  - Jinsheng We
AU  - Lin Shen
AU  - Jin Li
AU  - Wangjun Liao
AU  - Zhen Li
AU  - Lei Yang
AU  - Yovany Eduardo Rodriguez Pena
AU  - Ivan Jose Bustillo
AU  - Carlos Jose Narvaez
AU  - Manuel Enrique Gonzalez Fernandez
AU  - Raimundo Manneh
AU  - Andres Fernando Arenas Arias
AU  - Luis Corrales
AU  - Andres Wiernik Rodriguez
AU  - Thomas Aparicio
AU  - Yuan Touchefeu
AU  - Helene Boussion-Desloges
AU  - Laurent Mineur
AU  - Christophe Tournigand
AU  - Francois Ghiringhelli
AU  - Marie Pierre Galais
AU  - Eric Terrebonne
AU  - Thomas Walter
AU  - Mathieu Baconnier
AU  - Sylvie Lorenzen
AU  - Eray Goekkurt
AU  - Annika Kurreck
AU  - Arne Kandulski
AU  - Thorsten Goetze
AU  - Florian Lordick
AU  - Mynor Aguilar
AU  - Karla Alejandra Lopez
AU  - Rixci Augusto Lenin Ramirez Fallas
AU  - Pier Anyelo Ramos Elias
AU  - Juan Pablo Moreira
AU  - Wing Lok Wendy Chan
AU  - Ashely Cheng
AU  - Winnie Yeo
AU  - Maeve Lowery
AU  - Adrian Murphy
AU  - Sharon Pelles Avraham
AU  - Ayala Hubert
AU  - Irit Ben-Aharon
AU  - Valeriya Semenisty
AU  - Gali Perl
AU  - Wael Hozaeel
AU  - Armando Santoro
AU  - Elena Aurelia Mazza
AU  - Ferdinando de Vita
AU  - Guiseppe Aprile
AU  - Giovanni Gerardo Cardellino
AU  - Filippo Pietrantonio
AU  - Pierfrancesco Tassone
AU  - Kohei Shitara
AU  - Hirokazu Shoji
AU  - Yukiya Narita
AU  - Hiroki Hara
AU  - Kensei Yamaguchi
AU  - Naotoshi Sugimoto
AU  - Nozomu Machida
AU  - Tomohiro Nishina
AU  - Akihito Tsuji
AU  - Yasuhiro Choda
AU  - Kenji Amagai
AU  - Masahiro Tsuda
AU  - Shogen Boku
AU  - Boguslawa Karaszewska
AU  - Kamil Stanislaw Kuc
AU  - Jacek Mackiewicz
AU  - Lucjan Stanislaw Wyrwicz
AU  - Lukasz Hajac
AU  - Alexy Alexandrovich Tryakin
AU  - Dmitry Aleksandrovich Nosov
AU  - Rashida Orlova
AU  - Alexey Mikhailovich Karachun
AU  - Michael Osipov
AU  - Mikhail Valerievich Kopp
AU  - Natalia Vladimirovna Fadeeva
AU  - Nikolay Viktorovich Kislov
AU  - Sun Young Rha
AU  - Seung Tae Kim
AU  - Min-Hee Ryu
AU  - Do-Youn Oh
AU  - Keun-Wook Lee
AU  - Hei-Cheul Jeung
AU  - Jonggwon Choi
AU  - Sang Cheul Oh
AU  - Paula Jimenez Fonseca
AU  - Fernando Rivera Herrero
AU  - Pilar Aitana Calvo Ferrandiz
AU  - Daniel Acosta Eyzaguirre
AU  - Kun-Huei Yeh
AU  - Jen-Shi Chen
AU  - Li-Yuan Bai
AU  - Chia-Jui Yen
AU  - Bulent Erdogan
AU  - Pinar Gursoy
AU  - Mustafa Ozguroglu
AU  - Suayib Yalcin
AU  - Umut Demirci
AU  - Mehmet Bilici
AU  - Ilhan Hacibekiroglu
AU  - Hugo Ford
AU  - Kai-Keen Shiu
AU  - Martin Scott-Brown
AU  - Russell Petty
AU  - Wasat Mansoor
AU  - Zev A. Wainberg
AU  - Marcus Noel
AU  - Peter Enzinger
AU  - Sreenivasa Chandana
AU  - Geoffrey Ku
AU  - Dierdre Cohen
AU  - Vincent Lam
PY  - 2025
JO  - Journal of Clinical Oncology
DO  - 10.1200/jco-25-00748
UR  - https://doi.org/10.1200/jco-25-00748
ER  -

APA

Shitara, K., Lorenzen, S., Li, J., Bai, Y., Fernández, M. G., Aguilar, M., Shoji, H., Reyes-Cosmelli, F., Peña, Y. R., Corrales, L., Wyrwicz, L., Eyzaguirre, D. A., Pan, Y., Ryu, M., Cohen, D. J., Wainberg, Z. A., Ku, G., Tabernero, J., Cutsem, E. V., Qin, S., Oh, D., Xu, J., Liang, L. W., Bordia, S., Bhagia, P., Rha, S. Y., Unknown, Slutsky, E. H., Cundom, J., Soria, A. G., Carballido, M. A., O'Connor, J. M., Grasseli, J., Burge, M., Brungs, D. P., Khattak, M. A., Geboes, K. P. J., Cutsem, E. V., Dekervel, J., Hondt, L. D., Lemay, F., Juergens, R. A., Reyes, F., Brito, G. P., Ojeda, M. A., Araya, H. A., Yanez, P. E., Yang, J., Chen, X., Bai, Y., Pan, H., Xu, N., Pan, Y., Guo, Q., Liu, B., Ye, F., Wang, X., Li, Q., Tang, Y., Xu, H., Su, H., Cheng, Y., Yin, X., Zhao, Q., Li, N., You, J., Ba, Y., We, J., Shen, L., Li, J., Liao, W., Li, Z., Yang, L., Pena, Y. E. R., Bustillo, I. J., Narvaez, C. J., Fernandez, M. E. G., Manneh, R., Arias, A. F. A., Corrales, L., Rodriguez, A. W., Aparicio, T., Touchefeu, Y., Boussion-Desloges, H., Mineur, L., Tournigand, C., Ghiringhelli, F., Galais, M. P., Terrebonne, E., Walter, T., Baconnier, M., Lorenzen, S., Goekkurt, E., Kurreck, A., Kandulski, A., Goetze, T., Lordick, F., Aguilar, M., Lopez, K. A., Fallas, R. A. L. R., Elias, P. A. R., Moreira, J. P., Chan, W. L. W., Cheng, A., Yeo, W., Lowery, M., Murphy, A., Avraham, S. P., Hubert, A., Ben-Aharon, I., Semenisty, V., Perl, G., Hozaeel, W., Santoro, A., Mazza, E. A., Vita, F. D., Aprile, G., Cardellino, G. G., Pietrantonio, F., Tassone, P., Shitara, K., Shoji, H., Narita, Y., Hara, H., Yamaguchi, K., Sugimoto, N., Machida, N., Nishina, T., Tsuji, A., Choda, Y., Amagai, K., Tsuda, M., Boku, S., Karaszewska, B., Kuc, K. S., Mackiewicz, J., Wyrwicz, L. S., Hajac, L., Tryakin, A. A., Nosov, D. A., Orlova, R., Karachun, A. M., Osipov, M., Kopp, M. V., Fadeeva, N. V., Kislov, N. V., Rha, S. Y., Kim, S. T., Ryu, M., Oh, D., Lee, K., Jeung, H., Choi, J., Oh, S. C., Fonseca, P. J., Herrero, F. R., Ferrandiz, P. A. C., Eyzaguirre, D. A., Yeh, K., Chen, J., Bai, L., Yen, C., Erdogan, B., Gursoy, P., Ozguroglu, M., Yalcin, S., Demirci, U., Bilici, M., Hacibekiroglu, I., Ford, H., Shiu, K., Scott-Brown, M., Petty, R., Mansoor, W., Wainberg, Z. A., Noel, M., Enzinger, P., Chandana, S., Ku, G., Cohen, D., & Lam, V. (2025). Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study. Journal of Clinical Oncology. https://doi.org/10.1200/jco-25-00748

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