Genetic substructure in Latin American individuals reveals novel associations, mechanistic insights, and variable polygenic risk score transferability for alcohol traits

Janitza Montalvo-Ortiz, José Martínez-Magaña, Diego Andrade Brito, Eirini Trichia, Melody Rivera-Hernández, Luz Porras, Kyle Sullivan, Daniel Jacobson, Rachel Kember, Diana Nuñez, Jason Torres, Roseann Peterson, Hang Zhou, Anna Vlot, Jean Merlet, Alice Townsend, Alana Wells, Christiane Alvarez, Matthew Lane, Jesus Alegre-Díaz, Jaime Berumen, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jonathan Emberson, Henry Kranzler, Amy Justice, Joel Gelernter, Sandra Sanchez-Roige, Sylvia Wassertheil-Smoller, Krista Perreira, Martha Daviglus, Humberto Nicolini, Alma Genis-Mendoza, Jorge Villatoro-Velazquez, Maria Medina-Mora, Marycarmen Bustos-Gamiño, Sintia Belangero, Marcos Santoro, Luis Rohde, Rodrigo Bressan, Euripedes Miguel, Pedro Pan, Giovanni Salum, Katherine Tucker, Jose Ordovas, Dawn Coletta, Oscar Parra, Yann Klimentidis, Lawrence Mandarino, Mariana Moysés-Oliveira, Priscila Tempaku, Monica Andersen, Sergio Tufik, Eva Lancaster, Madhurbain Singh, María Tusié-Luna, Carlos Aguilar-Salinas, Ana Ochoa-Guzmán, Alexandre Pereira, Karen Martinez-Gonzalez, Cynthia Bulik, Spit for Science Working Group, Unknown, Latin American Genomics Consortium, Elizabeth Atkinson, Paola Giusti-Rodríguez

Open source

DOI: 10.21203/rs.3.rs-8789707/v1
Published: 2026-02-27
Container: Not recorded
Publisher: Springer Science and Business Media LLC
Open access: unknown

Credibility signals

uncertain Score 60/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
cautionPublication version: Identified as a preprint; peer review and later versions may change the record. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.21203/rs.3.rs-8789707/v1,
  title = {Genetic substructure in Latin American individuals reveals novel associations, mechanistic insights, and variable polygenic risk score transferability for alcohol traits},
  author = {Janitza Montalvo-Ortiz and José Martínez-Magaña and Diego Andrade Brito and Eirini Trichia and Melody Rivera-Hernández and Luz Porras and Kyle Sullivan and Daniel Jacobson and Rachel Kember and Diana Nuñez and Jason Torres and Roseann Peterson and Hang Zhou and Anna Vlot and Jean Merlet and Alice Townsend and Alana Wells and Christiane Alvarez and Matthew Lane and Jesus Alegre-Díaz and Jaime Berumen and Pablo Kuri-Morales and Roberto Tapia-Conyer and Jonathan Emberson and Henry Kranzler and Amy Justice and Joel Gelernter and Sandra Sanchez-Roige and Sylvia Wassertheil-Smoller and Krista Perreira and Martha Daviglus and Humberto Nicolini and Alma Genis-Mendoza and Jorge Villatoro-Velazquez and Maria Medina-Mora and Marycarmen Bustos-Gamiño and Sintia Belangero and Marcos Santoro and Luis Rohde and Rodrigo Bressan and Euripedes Miguel and Pedro Pan and Giovanni Salum and Katherine Tucker and Jose Ordovas and Dawn Coletta and Oscar Parra and Yann Klimentidis and Lawrence Mandarino and Mariana Moysés-Oliveira and Priscila Tempaku and Monica Andersen and Sergio Tufik and Eva Lancaster and Madhurbain Singh and María Tusié-Luna and Carlos Aguilar-Salinas and Ana Ochoa-Guzmán and Alexandre Pereira and Karen Martinez-Gonzalez and Cynthia Bulik and Spit for Science Working Group and Unknown and Latin American Genomics Consortium and Elizabeth Atkinson and Paola Giusti-Rodríguez},
  year = {2026},
  doi = {10.21203/rs.3.rs-8789707/v1},
  url = {https://doi.org/10.21203/rs.3.rs-8789707/v1}
}

RIS

TY  - JOUR
TI  - Genetic substructure in Latin American individuals reveals novel associations, mechanistic insights, and variable polygenic risk score transferability for alcohol traits
AU  - Janitza Montalvo-Ortiz
AU  - José Martínez-Magaña
AU  - Diego Andrade Brito
AU  - Eirini Trichia
AU  - Melody Rivera-Hernández
AU  - Luz Porras
AU  - Kyle Sullivan
AU  - Daniel Jacobson
AU  - Rachel Kember
AU  - Diana Nuñez
AU  - Jason Torres
AU  - Roseann Peterson
AU  - Hang Zhou
AU  - Anna Vlot
AU  - Jean Merlet
AU  - Alice Townsend
AU  - Alana Wells
AU  - Christiane Alvarez
AU  - Matthew Lane
AU  - Jesus Alegre-Díaz
AU  - Jaime Berumen
AU  - Pablo Kuri-Morales
AU  - Roberto Tapia-Conyer
AU  - Jonathan Emberson
AU  - Henry Kranzler
AU  - Amy Justice
AU  - Joel Gelernter
AU  - Sandra Sanchez-Roige
AU  - Sylvia Wassertheil-Smoller
AU  - Krista Perreira
AU  - Martha Daviglus
AU  - Humberto Nicolini
AU  - Alma Genis-Mendoza
AU  - Jorge Villatoro-Velazquez
AU  - Maria Medina-Mora
AU  - Marycarmen Bustos-Gamiño
AU  - Sintia Belangero
AU  - Marcos Santoro
AU  - Luis Rohde
AU  - Rodrigo Bressan
AU  - Euripedes Miguel
AU  - Pedro Pan
AU  - Giovanni Salum
AU  - Katherine Tucker
AU  - Jose Ordovas
AU  - Dawn Coletta
AU  - Oscar Parra
AU  - Yann Klimentidis
AU  - Lawrence Mandarino
AU  - Mariana Moysés-Oliveira
AU  - Priscila Tempaku
AU  - Monica Andersen
AU  - Sergio Tufik
AU  - Eva Lancaster
AU  - Madhurbain Singh
AU  - María Tusié-Luna
AU  - Carlos Aguilar-Salinas
AU  - Ana Ochoa-Guzmán
AU  - Alexandre Pereira
AU  - Karen Martinez-Gonzalez
AU  - Cynthia Bulik
AU  - Spit for Science Working Group
AU  - Unknown
AU  - Latin American Genomics Consortium
AU  - Elizabeth Atkinson
AU  - Paola Giusti-Rodríguez
PY  - 2026
DO  - 10.21203/rs.3.rs-8789707/v1
UR  - https://doi.org/10.21203/rs.3.rs-8789707/v1
ER  -

APA

Montalvo-Ortiz, J., Martínez-Magaña, J., Brito, D. A., Trichia, E., Rivera-Hernández, M., Porras, L., Sullivan, K., Jacobson, D., Kember, R., Nuñez, D., Torres, J., Peterson, R., Zhou, H., Vlot, A., Merlet, J., Townsend, A., Wells, A., Alvarez, C., Lane, M., Alegre-Díaz, J., Berumen, J., Kuri-Morales, P., Tapia-Conyer, R., Emberson, J., Kranzler, H., Justice, A., Gelernter, J., Sanchez-Roige, S., Wassertheil-Smoller, S., Perreira, K., Daviglus, M., Nicolini, H., Genis-Mendoza, A., Villatoro-Velazquez, J., Medina-Mora, M., Bustos-Gamiño, M., Belangero, S., Santoro, M., Rohde, L., Bressan, R., Miguel, E., Pan, P., Salum, G., Tucker, K., Ordovas, J., Coletta, D., Parra, O., Klimentidis, Y., Mandarino, L., Moysés-Oliveira, M., Tempaku, P., Andersen, M., Tufik, S., Lancaster, E., Singh, M., Tusié-Luna, M., Aguilar-Salinas, C., Ochoa-Guzmán, A., Pereira, A., Martinez-Gonzalez, K., Bulik, C., Group, S. F. S. W., Unknown, Consortium, L. A. G., Atkinson, E., & Giusti-Rodríguez, P. (2026). Genetic substructure in Latin American individuals reveals novel associations, mechanistic insights, and variable polygenic risk score transferability for alcohol traits. https://doi.org/10.21203/rs.3.rs-8789707/v1

Source records

crossref · retrieved 2026-09-27T02:07:55.089Z