Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.

Jurgens SJ, Enzan N, Dinsmore IR, Choi SH, Luo J, Lipov A, Hartle C, Wang X, Marston NA, Weng LC, Melloni GE, Chalazan B, Gray MP, Pirruccello JP, Diaz A, Chaffin MD, Ornelas-Loredo A, Tang O, Darbar FA, Kany S, Chen Y, von Falkenhausen AS, Morrison AC, Natale A, Tveit A, Geelhoed B, Cade B, Van Wagoner DR, Haase D, Soliman EZ, Davogustto GE, Calkins H, Anderson JL, Brody JA, Barnard J, Hokanson JE, Smith JD, Bis JC, Young K, Johnson LS, Long L, Risch L, Gula LJ, Kwee LC, Kühne M, Preuss M, Gupta N, Nafissi NA, Smith NL, Nilsson PM, van der Harst P, Wells QS, Judy RL, Schnabel RB, Johnson R, Smit RA, Gabriel S, Knight S, Furukawa T, Min YI, Yoneda ZT, Laksman ZW, Alonso A, Psaty BM, Albert CM, Arking DE, Roden DM, Chasman DI, Rader DJ, Conen D, McManus DD, Fatkin D, Boerwinkle E, Marcus GM, Christophersen IE, Smith JG, Roberts JD, Raffield LM, Shoemaker MB, Cho MH, Cutler MJ, Chung MK, Olesen MS, Sinner MF, Sotoodehnia N, Kirchhof P, Loos RJ, Nazarian S, Mohanty S, Damrauer SM, Kaab S, Heckbert SR, Redline S, Shah SH, Tanaka T, Ebana Y, Regeneron Genetics Center, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Lubitz SA, Lunetta KL, Benjamin EJ, Rienstra M, Figtree GA, Darbar D, Bezzina CR, Ruff CT, Sabatine MS, Mirshahi T, Ellinor PT

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DOI: 10.21203/rs.3.rs-9191644/v1
Published: 2026 May 4
Container: Research square
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.21203/rs.3.rs-9191644/v1,
  title = {Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.},
  author = {Jurgens SJ and Enzan N and Dinsmore IR and Choi SH and Luo J and Lipov A and Hartle C and Wang X and Marston NA and Weng LC and Melloni GE and Chalazan B and Gray MP and Pirruccello JP and Diaz A and Chaffin MD and Ornelas-Loredo A and Tang O and Darbar FA and Kany S and Chen Y and von Falkenhausen AS and Morrison AC and Natale A and Tveit A and Geelhoed B and Cade B and Van Wagoner DR and Haase D and Soliman EZ and Davogustto GE and Calkins H and Anderson JL and Brody JA and Barnard J and Hokanson JE and Smith JD and Bis JC and Young K and Johnson LS and Long L and Risch L and Gula LJ and Kwee LC and Kühne M and Preuss M and Gupta N and Nafissi NA and Smith NL and Nilsson PM and van der Harst P and Wells QS and Judy RL and Schnabel RB and Johnson R and Smit RA and Gabriel S and Knight S and Furukawa T and Min YI and Yoneda ZT and Laksman ZW and Alonso A and Psaty BM and Albert CM and Arking DE and Roden DM and Chasman DI and Rader DJ and Conen D and McManus DD and Fatkin D and Boerwinkle E and Marcus GM and Christophersen IE and Smith JG and Roberts JD and Raffield LM and Shoemaker MB and Cho MH and Cutler MJ and Chung MK and Olesen MS and Sinner MF and Sotoodehnia N and Kirchhof P and Loos RJ and Nazarian S and Mohanty S and Damrauer SM and Kaab S and Heckbert SR and Redline S and Shah SH and Tanaka T and Ebana Y and Regeneron Genetics Center and NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium and Lubitz SA and Lunetta KL and Benjamin EJ and Rienstra M and Figtree GA and Darbar D and Bezzina CR and Ruff CT and Sabatine MS and Mirshahi T and Ellinor PT},
  year = {2026},
  journal = {Research square},
  doi = {10.21203/rs.3.rs-9191644/v1},
  url = {https://doi.org/10.21203/rs.3.rs-9191644/v1}
}

RIS

TY  - JOUR
TI  - Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.
AU  - Jurgens SJ
AU  - Enzan N
AU  - Dinsmore IR
AU  - Choi SH
AU  - Luo J
AU  - Lipov A
AU  - Hartle C
AU  - Wang X
AU  - Marston NA
AU  - Weng LC
AU  - Melloni GE
AU  - Chalazan B
AU  - Gray MP
AU  - Pirruccello JP
AU  - Diaz A
AU  - Chaffin MD
AU  - Ornelas-Loredo A
AU  - Tang O
AU  - Darbar FA
AU  - Kany S
AU  - Chen Y
AU  - von Falkenhausen AS
AU  - Morrison AC
AU  - Natale A
AU  - Tveit A
AU  - Geelhoed B
AU  - Cade B
AU  - Van Wagoner DR
AU  - Haase D
AU  - Soliman EZ
AU  - Davogustto GE
AU  - Calkins H
AU  - Anderson JL
AU  - Brody JA
AU  - Barnard J
AU  - Hokanson JE
AU  - Smith JD
AU  - Bis JC
AU  - Young K
AU  - Johnson LS
AU  - Long L
AU  - Risch L
AU  - Gula LJ
AU  - Kwee LC
AU  - Kühne M
AU  - Preuss M
AU  - Gupta N
AU  - Nafissi NA
AU  - Smith NL
AU  - Nilsson PM
AU  - van der Harst P
AU  - Wells QS
AU  - Judy RL
AU  - Schnabel RB
AU  - Johnson R
AU  - Smit RA
AU  - Gabriel S
AU  - Knight S
AU  - Furukawa T
AU  - Min YI
AU  - Yoneda ZT
AU  - Laksman ZW
AU  - Alonso A
AU  - Psaty BM
AU  - Albert CM
AU  - Arking DE
AU  - Roden DM
AU  - Chasman DI
AU  - Rader DJ
AU  - Conen D
AU  - McManus DD
AU  - Fatkin D
AU  - Boerwinkle E
AU  - Marcus GM
AU  - Christophersen IE
AU  - Smith JG
AU  - Roberts JD
AU  - Raffield LM
AU  - Shoemaker MB
AU  - Cho MH
AU  - Cutler MJ
AU  - Chung MK
AU  - Olesen MS
AU  - Sinner MF
AU  - Sotoodehnia N
AU  - Kirchhof P
AU  - Loos RJ
AU  - Nazarian S
AU  - Mohanty S
AU  - Damrauer SM
AU  - Kaab S
AU  - Heckbert SR
AU  - Redline S
AU  - Shah SH
AU  - Tanaka T
AU  - Ebana Y
AU  - Regeneron Genetics Center
AU  - NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
AU  - Lubitz SA
AU  - Lunetta KL
AU  - Benjamin EJ
AU  - Rienstra M
AU  - Figtree GA
AU  - Darbar D
AU  - Bezzina CR
AU  - Ruff CT
AU  - Sabatine MS
AU  - Mirshahi T
AU  - Ellinor PT
PY  - 2026
JO  - Research square
DO  - 10.21203/rs.3.rs-9191644/v1
UR  - https://doi.org/10.21203/rs.3.rs-9191644/v1
ER  -

APA

SJ, J., N, E., IR, D., SH, C., J, L., A, L., C, H., X, W., NA, M., LC, W., GE, M., B, C., MP, G., JP, P., A, D., MD, C., A, O., O, T., FA, D., S, K., Y, C., AS, V. F., AC, M., A, N., A, T., B, G., B, C., DR, V. W., D, H., EZ, S., GE, D., H, C., JL, A., JA, B., J, B., JE, H., JD, S., JC, B., K, Y., LS, J., L, L., L, R., LJ, G., LC, K., M, K., M, P., N, G., NA, N., NL, S., PM, N., P, V. D. H., QS, W., RL, J., RB, S., R, J., RA, S., S, G., S, K., T, F., YI, M., ZT, Y., ZW, L., A, A., BM, P., CM, A., DE, A., DM, R., DI, C., DJ, R., D, C., DD, M., D, F., E, B., GM, M., IE, C., JG, S., JD, R., LM, R., MB, S., MH, C., MJ, C., MK, C., MS, O., MF, S., N, S., P, K., RJ, L., S, N., S, M., SM, D., S, K., SR, H., S, R., SH, S., T, T., Y, E., Center, R. G., Consortium, N. T. F. P. M. (., SA, L., KL, L., EJ, B., M, R., GA, F., D, D., CR, B., CT, R., MS, S., T, M., & PT, E. (2026). Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.. Research square. https://doi.org/10.21203/rs.3.rs-9191644/v1

Source records

pubmed · retrieved 2026-09-26T03:53:43.410Z