First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations.

Zhang J, Wang X, Xu H, Zang A, Zhao J, Chen J, Lei R, Zhang Z, Hao C, Liu Y, Zhou R, He L, Sun T, Ouyang Q, Chen S, Xu J, Zhou W, Shi Y, Tong Z

Open source

DOI: 10.2147/dddt.s606617
Published: 2026
Container: Drug design, development and therapy
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.2147/dddt.s606617,
  title = {First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations.},
  author = {Zhang J and Wang X and Xu H and Zang A and Zhao J and Chen J and Lei R and Zhang Z and Hao C and Liu Y and Zhou R and He L and Sun T and Ouyang Q and Chen S and Xu J and Zhou W and Shi Y and Tong Z},
  year = {2026},
  journal = {Drug design, development and therapy},
  doi = {10.2147/dddt.s606617},
  url = {https://doi.org/10.2147/dddt.s606617}
}

RIS

TY  - JOUR
TI  - First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations.
AU  - Zhang J
AU  - Wang X
AU  - Xu H
AU  - Zang A
AU  - Zhao J
AU  - Chen J
AU  - Lei R
AU  - Zhang Z
AU  - Hao C
AU  - Liu Y
AU  - Zhou R
AU  - He L
AU  - Sun T
AU  - Ouyang Q
AU  - Chen S
AU  - Xu J
AU  - Zhou W
AU  - Shi Y
AU  - Tong Z
PY  - 2026
JO  - Drug design, development and therapy
DO  - 10.2147/dddt.s606617
UR  - https://doi.org/10.2147/dddt.s606617
ER  -

APA

J, Z., X, W., H, X., A, Z., J, Z., J, C., R, L., Z, Z., C, H., Y, L., R, Z., L, H., T, S., Q, O., S, C., J, X., W, Z., Y, S., & Z, T. (2026). First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations.. Drug design, development and therapy. https://doi.org/10.2147/dddt.s606617

Source records

pubmed · retrieved 2026-09-25T23:38:37.143Z