Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy Murphy, Angus D. Cowan, Kwok Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli

Open source

DOI: 10.25405/ncl.34436718.v1
Published: 2026
Container: Not recorded
Publisher: Newcastle University
Open access: no

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Cite this work

BibTeX

@article{allodium:10.25405/ncl.34436718.v1,
  title = {Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity},
  author = {Satomi Imaide and Kristin M. Riching and Nikolai Makukhin and Vesna Vetma and Claire Whitworth and Scott J. Hughes and Nicole Trainor and Sarah D. Mahan and Nancy Murphy and Angus D. Cowan and Kwok Ho Chan and Conner Craigon and Andrea Testa and Chiara Maniaci and Marjeta Urh and Danette L. Daniels and Alessio Ciulli},
  year = {2026},
  doi = {10.25405/ncl.34436718.v1},
  url = {https://doi.org/10.25405/ncl.34436718.v1}
}

RIS

TY  - JOUR
TI  - Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
AU  - Satomi Imaide
AU  - Kristin M. Riching
AU  - Nikolai Makukhin
AU  - Vesna Vetma
AU  - Claire Whitworth
AU  - Scott J. Hughes
AU  - Nicole Trainor
AU  - Sarah D. Mahan
AU  - Nancy Murphy
AU  - Angus D. Cowan
AU  - Kwok Ho Chan
AU  - Conner Craigon
AU  - Andrea Testa
AU  - Chiara Maniaci
AU  - Marjeta Urh
AU  - Danette L. Daniels
AU  - Alessio Ciulli
PY  - 2026
DO  - 10.25405/ncl.34436718.v1
UR  - https://doi.org/10.25405/ncl.34436718.v1
ER  -

APA

Imaide, S., Riching, K. M., Makukhin, N., Vetma, V., Whitworth, C., Hughes, S. J., Trainor, N., Mahan, S. D., Murphy, N., Cowan, A. D., Chan, K. H., Craigon, C., Testa, A., Maniaci, C., Urh, M., Daniels, D. L., & Ciulli, A. (2026). Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity. https://doi.org/10.25405/ncl.34436718.v1

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datacite · retrieved 2026-11-10T13:27:29.191Z