Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.

Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC

Open source

DOI: 10.26508/lsa.201800190
Published: 2018 Oct
Container: Life science alliance
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.26508/lsa.201800190,
  title = {Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.},
  author = {Pitarresi JR and Liu X and Avendano A and Thies KA and Sizemore GM and Hammer AM and Hildreth BE 3rd and Wang DJ and Steck SA and Donohue S and Cuitiño MC and Kladney RD and Mace TA and Chang JJ and Ennis CS and Li H and Reeves RH and Blackshaw S and Zhang J and Yu L and Fernandez SA and Frankel WL and Bloomston M and Rosol TJ and Lesinski GB and Konieczny SF and Guttridge DC and Rustgi AK and Leone G and Song JW and Wu J and Ostrowski MC},
  year = {2018},
  journal = {Life science alliance},
  doi = {10.26508/lsa.201800190},
  url = {https://doi.org/10.26508/lsa.201800190}
}

RIS

TY  - JOUR
TI  - Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
AU  - Pitarresi JR
AU  - Liu X
AU  - Avendano A
AU  - Thies KA
AU  - Sizemore GM
AU  - Hammer AM
AU  - Hildreth BE 3rd
AU  - Wang DJ
AU  - Steck SA
AU  - Donohue S
AU  - Cuitiño MC
AU  - Kladney RD
AU  - Mace TA
AU  - Chang JJ
AU  - Ennis CS
AU  - Li H
AU  - Reeves RH
AU  - Blackshaw S
AU  - Zhang J
AU  - Yu L
AU  - Fernandez SA
AU  - Frankel WL
AU  - Bloomston M
AU  - Rosol TJ
AU  - Lesinski GB
AU  - Konieczny SF
AU  - Guttridge DC
AU  - Rustgi AK
AU  - Leone G
AU  - Song JW
AU  - Wu J
AU  - Ostrowski MC
PY  - 2018
JO  - Life science alliance
DO  - 10.26508/lsa.201800190
UR  - https://doi.org/10.26508/lsa.201800190
ER  -

APA

JR, P., X, L., A, A., KA, T., GM, S., AM, H., 3rd, H. B., DJ, W., SA, S., S, D., MC, C., RD, K., TA, M., JJ, C., CS, E., H, L., RH, R., S, B., J, Z., L, Y., SA, F., WL, F., M, B., TJ, R., GB, L., SF, K., DC, G., AK, R., G, L., JW, S., J, W., & MC, O. (2018). Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.. Life science alliance. https://doi.org/10.26508/lsa.201800190

Source records

pubmed · retrieved 2026-09-25T00:55:28.613Z