Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability

Madeleine Schmidt, Puyan Rafii, Aisha AlShamsi, Giovanni Zifarelli, Maxi Leona Wiese, Joachim David Steiner, Sarah Kreuz, Robert Walter Körner, Clara Velmans, Christian Netzer, Oliver Semler, Majid Alfadhel, Hiba Abu Khalil, Ezgi Susam, Sujatha Jagadeesh, Beena Suresh, Nicolai Kohlschmidt, Philip M. Boone, Sheela Nampoothiri, Radhakrishnan Periyasamy, Katta M. Girisha, Andreas Hahn, Adela Chirita-Emandi, Raphael Hirtz, Kai O. Hensel, Peter Bauer, Konstantin L. Makridis, Angela M. Kaindl, Ilja Dubinski, Jürgen-Christoph von Kleist-Retzow, Gregor Dückers, Reem Elfeky, Maaike Kusters, Tim Niehues, Vivien Béziat, Heinz Jungbluth, Adam Antebi, Jürgen Scheller, Hormos S. Dafsari

Open source

DOI: 10.3389/fimmu.2026.1927542
Published: 2026-10-19
Container: Frontiers in Immunology
Publisher: Frontiers Media SA
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.3389/fimmu.2026.1927542,
  title = {Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability},
  author = {Madeleine Schmidt and Puyan Rafii and Aisha AlShamsi and Giovanni Zifarelli and Maxi Leona Wiese and Joachim David Steiner and Sarah Kreuz and Robert Walter Körner and Clara Velmans and Christian Netzer and Oliver Semler and Majid Alfadhel and Hiba Abu Khalil and Ezgi Susam and Sujatha Jagadeesh and Beena Suresh and Nicolai Kohlschmidt and Philip M. Boone and Sheela Nampoothiri and Radhakrishnan Periyasamy and Katta M. Girisha and Andreas Hahn and Adela Chirita-Emandi and Raphael Hirtz and Kai O. Hensel and Peter Bauer and Konstantin L. Makridis and Angela M. Kaindl and Ilja Dubinski and Jürgen-Christoph von Kleist-Retzow and Gregor Dückers and Reem Elfeky and Maaike Kusters and Tim Niehues and Vivien Béziat and Heinz Jungbluth and Adam Antebi and Jürgen Scheller and Hormos S. Dafsari},
  year = {2026},
  journal = {Frontiers in Immunology},
  doi = {10.3389/fimmu.2026.1927542},
  url = {https://doi.org/10.3389/fimmu.2026.1927542}
}

RIS

TY  - JOUR
TI  - Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability
AU  - Madeleine Schmidt
AU  - Puyan Rafii
AU  - Aisha AlShamsi
AU  - Giovanni Zifarelli
AU  - Maxi Leona Wiese
AU  - Joachim David Steiner
AU  - Sarah Kreuz
AU  - Robert Walter Körner
AU  - Clara Velmans
AU  - Christian Netzer
AU  - Oliver Semler
AU  - Majid Alfadhel
AU  - Hiba Abu Khalil
AU  - Ezgi Susam
AU  - Sujatha Jagadeesh
AU  - Beena Suresh
AU  - Nicolai Kohlschmidt
AU  - Philip M. Boone
AU  - Sheela Nampoothiri
AU  - Radhakrishnan Periyasamy
AU  - Katta M. Girisha
AU  - Andreas Hahn
AU  - Adela Chirita-Emandi
AU  - Raphael Hirtz
AU  - Kai O. Hensel
AU  - Peter Bauer
AU  - Konstantin L. Makridis
AU  - Angela M. Kaindl
AU  - Ilja Dubinski
AU  - Jürgen-Christoph von Kleist-Retzow
AU  - Gregor Dückers
AU  - Reem Elfeky
AU  - Maaike Kusters
AU  - Tim Niehues
AU  - Vivien Béziat
AU  - Heinz Jungbluth
AU  - Adam Antebi
AU  - Jürgen Scheller
AU  - Hormos S. Dafsari
PY  - 2026
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1927542
UR  - https://doi.org/10.3389/fimmu.2026.1927542
ER  -

APA

Schmidt, M., Rafii, P., AlShamsi, A., Zifarelli, G., Wiese, M. L., Steiner, J. D., Kreuz, S., Körner, R. W., Velmans, C., Netzer, C., Semler, O., Alfadhel, M., Khalil, H. A., Susam, E., Jagadeesh, S., Suresh, B., Kohlschmidt, N., Boone, P. M., Nampoothiri, S., Periyasamy, R., Girisha, K. M., Hahn, A., Chirita-Emandi, A., Hirtz, R., Hensel, K. O., Bauer, P., Makridis, K. L., Kaindl, A. M., Dubinski, I., Kleist-Retzow, J. V., Dückers, G., Elfeky, R., Kusters, M., Niehues, T., Béziat, V., Jungbluth, H., Antebi, A., Scheller, J., & Dafsari, H. S. (2026). Hypomorphic biallelic LIFR variants define a multisystem disorder with survival beyond infancy and hyperinflammatory vulnerability. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2026.1927542

Source records

crossref · retrieved 2026-11-04T08:55:26.743Z