Hydroxychloroquine-induced cytotoxicity in ARPE-19 cells involves PI3K/AKT-associated signaling: network toxicology and functional validation

Lan Lin, Yunhao Zhou, Guanghui Liu, Songjie Lu, Ting Huang, Zhaoyang Xu, Sheng Chen

Open source

DOI: 10.3389/fphar.2026.1917634
Published: 2026-10-26
Container: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.3389/fphar.2026.1917634,
  title = {Hydroxychloroquine-induced cytotoxicity in ARPE-19 cells involves PI3K/AKT-associated signaling: network toxicology and functional validation},
  author = {Lan Lin and Yunhao Zhou and Guanghui Liu and Songjie Lu and Ting Huang and Zhaoyang Xu and Sheng Chen},
  year = {2026},
  journal = {Frontiers in Pharmacology},
  doi = {10.3389/fphar.2026.1917634},
  url = {https://doi.org/10.3389/fphar.2026.1917634}
}

RIS

TY  - JOUR
TI  - Hydroxychloroquine-induced cytotoxicity in ARPE-19 cells involves PI3K/AKT-associated signaling: network toxicology and functional validation
AU  - Lan Lin
AU  - Yunhao Zhou
AU  - Guanghui Liu
AU  - Songjie Lu
AU  - Ting Huang
AU  - Zhaoyang Xu
AU  - Sheng Chen
PY  - 2026
JO  - Frontiers in Pharmacology
DO  - 10.3389/fphar.2026.1917634
UR  - https://doi.org/10.3389/fphar.2026.1917634
ER  -

APA

Lin, L., Zhou, Y., Liu, G., Lu, S., Huang, T., Xu, Z., & Chen, S. (2026). Hydroxychloroquine-induced cytotoxicity in ARPE-19 cells involves PI3K/AKT-associated signaling: network toxicology and functional validation. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2026.1917634

Source records

crossref · retrieved 2026-11-10T19:04:34.834Z