Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries

Stuart MacGregor, Guiyan Ni, Mathias Seviiri, Antonia Kolovos, Ngoc Quynh Le, Mark M Hassall, Josh Schmidt, Puya Gharahkhani, Victoria Tang, Emmanuelle Souzeau, Ayub Qassim, Priyanka Nandakumar, Suyash Shringarpure, Julie M Granka, Jessica N Cooke Bailey, Tin Aung, John Landers, Stuart L Graham, Paul R Healey, Anthony P Khawaja, Louis R Pasquale, Janey L Wiggs, Joan O’Brien, Robert N Weinreb, Colin E Willoughby, Andrew Lotery, Paul Mitchell, David A Mackey, Alex W Hewitt, Nick Haan, Owen M Siggs, Jamie E Craig

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DOI: 10.64898/2026.01.23.26344675
Published: 2026-01-24
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Publisher: openRxiv
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Cite this work

BibTeX

@article{allodium:10.64898/2026.01.23.26344675,
  title = {Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries},
  author = {Stuart MacGregor and Guiyan Ni and Mathias Seviiri and Antonia Kolovos and Ngoc Quynh Le and Mark M Hassall and Josh Schmidt and Puya Gharahkhani and Victoria Tang and Emmanuelle Souzeau and Ayub Qassim and Priyanka Nandakumar and Suyash Shringarpure and Julie M Granka and Jessica N Cooke Bailey and Tin Aung and John Landers and Stuart L Graham and Paul R Healey and Anthony P Khawaja and Louis R Pasquale and Janey L Wiggs and Joan O’Brien and Robert N Weinreb and Colin E Willoughby and Andrew Lotery and Paul Mitchell and David A Mackey and Alex W Hewitt and Nick Haan and Owen M Siggs and Jamie E Craig},
  year = {2026},
  doi = {10.64898/2026.01.23.26344675},
  url = {https://doi.org/10.64898/2026.01.23.26344675}
}

RIS

TY  - JOUR
TI  - Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries
AU  - Stuart MacGregor
AU  - Guiyan Ni
AU  - Mathias Seviiri
AU  - Antonia Kolovos
AU  - Ngoc Quynh Le
AU  - Mark M Hassall
AU  - Josh Schmidt
AU  - Puya Gharahkhani
AU  - Victoria Tang
AU  - Emmanuelle Souzeau
AU  - Ayub Qassim
AU  - Priyanka Nandakumar
AU  - Suyash Shringarpure
AU  - Julie M Granka
AU  - Jessica N Cooke Bailey
AU  - Tin Aung
AU  - John Landers
AU  - Stuart L Graham
AU  - Paul R Healey
AU  - Anthony P Khawaja
AU  - Louis R Pasquale
AU  - Janey L Wiggs
AU  - Joan O’Brien
AU  - Robert N Weinreb
AU  - Colin E Willoughby
AU  - Andrew Lotery
AU  - Paul Mitchell
AU  - David A Mackey
AU  - Alex W Hewitt
AU  - Nick Haan
AU  - Owen M Siggs
AU  - Jamie E Craig
PY  - 2026
DO  - 10.64898/2026.01.23.26344675
UR  - https://doi.org/10.64898/2026.01.23.26344675
ER  -

APA

MacGregor, S., Ni, G., Seviiri, M., Kolovos, A., Le, N. Q., Hassall, M. M., Schmidt, J., Gharahkhani, P., Tang, V., Souzeau, E., Qassim, A., Nandakumar, P., Shringarpure, S., Granka, J. M., Bailey, J. N. C., Aung, T., Landers, J., Graham, S. L., Healey, P. R., Khawaja, A. P., Pasquale, L. R., Wiggs, J. L., O’Brien, J., Weinreb, R. N., Willoughby, C. E., Lotery, A., Mitchell, P., Mackey, D. A., Hewitt, A. W., Haan, N., Siggs, O. M., & Craig, J. E. (2026). Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestries. https://doi.org/10.64898/2026.01.23.26344675

Source records

crossref · retrieved 2026-09-25T13:44:17.721Z