Trans-eQTLs reveal the architecture of human gene regulatory networks.

Warmerdam CAR, Westra HJ, van der Graaf A, Bonder MJ, Deelen P, van Lieshout T, Landman AJ, Jesse M, Strober BJ, Boltz T, Lapinska S, Nagpal S, Xie M, Tay D, Kirsten H, Naeem H, Raghavan V, Farzeen A, Teumer A, Favé MJ, Persyn E, Tokolyi A, Pool R, Hottenga JJ, Rodríguez RD, Rivas-Torrubia M, Mishra BH, Pierce B, Tong L, Wang QS, Hasegawa T, Chhetri SB, Dutta D, Weiss S, Dupuis T, Lyytikäinen LP, Mishra PP, Wood AR, Burnham KL, Wen J, Cheruiyot E, Boahen CK, Jansen R, Krohn K, Thiery J, IMI DIRECT Consortium, Daida K, Gibbs JR, Verlouw J, Kukushkina V, Mägi R, Budde J, Johnson M, Sanford J, Slagboom E, Beutner F, Loeffler M, PRECISESADS Clinical Consortium, Martin J, Raitoharju E, Kibriya MG, Jasmine F, Nauck M, HELIOS Study Team, Souto JC, Martinez-Perez A, Ikram MA, Mykkänen J, Pahkala K, Rovio SP, Raffield LM, van Greevenbroek M, van der Kallen CJH, Schalkwijk CG, Veldink J, Freimann K, Vochteloo M, Kooijmans A, Ouadah L, Claringbould A, Huang Y, Bryois J, Tsai EA, Heinig M, van der Wijst MGP, Estonian Biobank Research Team, sc-eQTLGen Consortium, Kumar V, Visscher PM, McRae AF, Montgomery GW, Li Y, Knight JC, Singleton A, Ferrucci L, Frayling TM, Brown A, Soria JM, Völker U, Battle A, Okada Y, Fukunaga K, Namkoong H, Ahsan H, Lehtimäki T, Kähönen M, Raitakari OT, Alarcón-Riquelme ME, Barturen G, Penninx BWJH, Paul DS, Inouye M, Awadalla P, Sung YJ, Cruchaga C, van Meurs J, Prokisch H, Peters A, Gieger C, Blauwendraat C, Mokrab Y, Davenport EE, Scholz M, Loh M, Chambers J, Gibson G, Boomsma DI, Viñuela A, Pasaniuc B, Ophoff R, Price AL, Alasoo K, Kutalik Z, Esko T, Franke LH, Võsa U

Open source

DOI: 10.64898/2026.02.04.26343575
Published: 2026 Feb 5
Container: medRxiv : the preprint server for health sciences
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.64898/2026.02.04.26343575,
  title = {Trans-eQTLs reveal the architecture of human gene regulatory networks.},
  author = {Warmerdam CAR and Westra HJ and van der Graaf A and Bonder MJ and Deelen P and van Lieshout T and Landman AJ and Jesse M and Strober BJ and Boltz T and Lapinska S and Nagpal S and Xie M and Tay D and Kirsten H and Naeem H and Raghavan V and Farzeen A and Teumer A and Favé MJ and Persyn E and Tokolyi A and Pool R and Hottenga JJ and Rodríguez RD and Rivas-Torrubia M and Mishra BH and Pierce B and Tong L and Wang QS and Hasegawa T and Chhetri SB and Dutta D and Weiss S and Dupuis T and Lyytikäinen LP and Mishra PP and Wood AR and Burnham KL and Wen J and Cheruiyot E and Boahen CK and Jansen R and Krohn K and Thiery J and IMI DIRECT Consortium and Daida K and Gibbs JR and Verlouw J and Kukushkina V and Mägi R and Budde J and Johnson M and Sanford J and Slagboom E and Beutner F and Loeffler M and PRECISESADS Clinical Consortium and Martin J and Raitoharju E and Kibriya MG and Jasmine F and Nauck M and HELIOS Study Team and Souto JC and Martinez-Perez A and Ikram MA and Mykkänen J and Pahkala K and Rovio SP and Raffield LM and van Greevenbroek M and van der Kallen CJH and Schalkwijk CG and Veldink J and Freimann K and Vochteloo M and Kooijmans A and Ouadah L and Claringbould A and Huang Y and Bryois J and Tsai EA and Heinig M and van der Wijst MGP and Estonian Biobank Research Team and sc-eQTLGen Consortium and Kumar V and Visscher PM and McRae AF and Montgomery GW and Li Y and Knight JC and Singleton A and Ferrucci L and Frayling TM and Brown A and Soria JM and Völker U and Battle A and Okada Y and Fukunaga K and Namkoong H and Ahsan H and Lehtimäki T and Kähönen M and Raitakari OT and Alarcón-Riquelme ME and Barturen G and Penninx BWJH and Paul DS and Inouye M and Awadalla P and Sung YJ and Cruchaga C and van Meurs J and Prokisch H and Peters A and Gieger C and Blauwendraat C and Mokrab Y and Davenport EE and Scholz M and Loh M and Chambers J and Gibson G and Boomsma DI and Viñuela A and Pasaniuc B and Ophoff R and Price AL and Alasoo K and Kutalik Z and Esko T and Franke LH and Võsa U},
  year = {2026},
  journal = {medRxiv : the preprint server for health sciences},
  doi = {10.64898/2026.02.04.26343575},
  url = {https://doi.org/10.64898/2026.02.04.26343575}
}

RIS

TY  - JOUR
TI  - Trans-eQTLs reveal the architecture of human gene regulatory networks.
AU  - Warmerdam CAR
AU  - Westra HJ
AU  - van der Graaf A
AU  - Bonder MJ
AU  - Deelen P
AU  - van Lieshout T
AU  - Landman AJ
AU  - Jesse M
AU  - Strober BJ
AU  - Boltz T
AU  - Lapinska S
AU  - Nagpal S
AU  - Xie M
AU  - Tay D
AU  - Kirsten H
AU  - Naeem H
AU  - Raghavan V
AU  - Farzeen A
AU  - Teumer A
AU  - Favé MJ
AU  - Persyn E
AU  - Tokolyi A
AU  - Pool R
AU  - Hottenga JJ
AU  - Rodríguez RD
AU  - Rivas-Torrubia M
AU  - Mishra BH
AU  - Pierce B
AU  - Tong L
AU  - Wang QS
AU  - Hasegawa T
AU  - Chhetri SB
AU  - Dutta D
AU  - Weiss S
AU  - Dupuis T
AU  - Lyytikäinen LP
AU  - Mishra PP
AU  - Wood AR
AU  - Burnham KL
AU  - Wen J
AU  - Cheruiyot E
AU  - Boahen CK
AU  - Jansen R
AU  - Krohn K
AU  - Thiery J
AU  - IMI DIRECT Consortium
AU  - Daida K
AU  - Gibbs JR
AU  - Verlouw J
AU  - Kukushkina V
AU  - Mägi R
AU  - Budde J
AU  - Johnson M
AU  - Sanford J
AU  - Slagboom E
AU  - Beutner F
AU  - Loeffler M
AU  - PRECISESADS Clinical Consortium
AU  - Martin J
AU  - Raitoharju E
AU  - Kibriya MG
AU  - Jasmine F
AU  - Nauck M
AU  - HELIOS Study Team
AU  - Souto JC
AU  - Martinez-Perez A
AU  - Ikram MA
AU  - Mykkänen J
AU  - Pahkala K
AU  - Rovio SP
AU  - Raffield LM
AU  - van Greevenbroek M
AU  - van der Kallen CJH
AU  - Schalkwijk CG
AU  - Veldink J
AU  - Freimann K
AU  - Vochteloo M
AU  - Kooijmans A
AU  - Ouadah L
AU  - Claringbould A
AU  - Huang Y
AU  - Bryois J
AU  - Tsai EA
AU  - Heinig M
AU  - van der Wijst MGP
AU  - Estonian Biobank Research Team
AU  - sc-eQTLGen Consortium
AU  - Kumar V
AU  - Visscher PM
AU  - McRae AF
AU  - Montgomery GW
AU  - Li Y
AU  - Knight JC
AU  - Singleton A
AU  - Ferrucci L
AU  - Frayling TM
AU  - Brown A
AU  - Soria JM
AU  - Völker U
AU  - Battle A
AU  - Okada Y
AU  - Fukunaga K
AU  - Namkoong H
AU  - Ahsan H
AU  - Lehtimäki T
AU  - Kähönen M
AU  - Raitakari OT
AU  - Alarcón-Riquelme ME
AU  - Barturen G
AU  - Penninx BWJH
AU  - Paul DS
AU  - Inouye M
AU  - Awadalla P
AU  - Sung YJ
AU  - Cruchaga C
AU  - van Meurs J
AU  - Prokisch H
AU  - Peters A
AU  - Gieger C
AU  - Blauwendraat C
AU  - Mokrab Y
AU  - Davenport EE
AU  - Scholz M
AU  - Loh M
AU  - Chambers J
AU  - Gibson G
AU  - Boomsma DI
AU  - Viñuela A
AU  - Pasaniuc B
AU  - Ophoff R
AU  - Price AL
AU  - Alasoo K
AU  - Kutalik Z
AU  - Esko T
AU  - Franke LH
AU  - Võsa U
PY  - 2026
JO  - medRxiv : the preprint server for health sciences
DO  - 10.64898/2026.02.04.26343575
UR  - https://doi.org/10.64898/2026.02.04.26343575
ER  -

APA

CAR, W., HJ, W., A, V. D. G., MJ, B., P, D., T, V. L., AJ, L., M, J., BJ, S., T, B., S, L., S, N., M, X., D, T., H, K., H, N., V, R., A, F., A, T., MJ, F., E, P., A, T., R, P., JJ, H., RD, R., M, R., BH, M., B, P., L, T., QS, W., T, H., SB, C., D, D., S, W., T, D., LP, L., PP, M., AR, W., KL, B., J, W., E, C., CK, B., R, J., K, K., J, T., Consortium, I. D., K, D., JR, G., J, V., V, K., R, M., J, B., M, J., J, S., E, S., F, B., M, L., Consortium, P. C., J, M., E, R., MG, K., F, J., M, N., Team, H. S., JC, S., A, M., MA, I., J, M., K, P., SP, R., LM, R., M, V. G., CJH, V. D. K., CG, S., J, V., K, F., M, V., A, K., L, O., A, C., Y, H., J, B., EA, T., M, H., MGP, V. D. W., Team, E. B. R., Consortium, S., V, K., PM, V., AF, M., GW, M., Y, L., JC, K., A, S., L, F., TM, F., A, B., JM, S., U, V., A, B., Y, O., K, F., H, N., H, A., T, L., M, K., OT, R., ME, A., G, B., BWJH, P., DS, P., M, I., P, A., YJ, S., C, C., J, V. M., H, P., A, P., C, G., C, B., Y, M., EE, D., M, S., M, L., J, C., G, G., DI, B., A, V., B, P., R, O., AL, P., K, A., Z, K., T, E., LH, F., & U, V. (2026). Trans-eQTLs reveal the architecture of human gene regulatory networks.. medRxiv : the preprint server for health sciences. https://doi.org/10.64898/2026.02.04.26343575

Source records

pubmed · retrieved 2026-09-25T12:27:16.586Z