Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated States

Francisco Hernandez-Rasco, Rocío Ruiz, Itziar de Rojas, Raquel Puerta, Clara Garcia-Mayor, Ana María Espinosa-Oliva, Juan García-Revilla, Paula Bayon, Alberto Rivera-Ramos, Farah Real Oualit, Sebastián Jiménez, Maria Eugenia Saez, Rocío M. de Pablos, Feiyang Zhao, Claudia Olive, Pilar Sanz, Xavier Montalbán, Sergi Valero, Amanda Cano, María Victoria Fernández, Anne Marie Wells, Jose Enrique Cavazos, Sudha Seshadri, Merce Boada, Santos Mañes, Michael T. Heneka, Francisco Javier Vitorica, Alfredo Ramirez, José Luis Venero, Agustín Ruiz

Open source

DOI: 10.64898/2026.02.21.26346696
Published: 2026-02-25
Container: Not recorded
Publisher: openRxiv
Open access: unknown

Credibility signals

uncertain Score 60/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
cautionPublication version: Identified as a preprint; peer review and later versions may change the record. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.64898/2026.02.21.26346696,
  title = {Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated States},
  author = {Francisco Hernandez-Rasco and Rocío Ruiz and Itziar de Rojas and Raquel Puerta and Clara Garcia-Mayor and Ana María Espinosa-Oliva and Juan García-Revilla and Paula Bayon and Alberto Rivera-Ramos and Farah Real Oualit and Sebastián Jiménez and Maria Eugenia Saez and Rocío M. de Pablos and Feiyang Zhao and Claudia Olive and Pilar Sanz and Xavier Montalbán and Sergi Valero and Amanda Cano and María Victoria Fernández and Anne Marie Wells and Jose Enrique Cavazos and Sudha Seshadri and Merce Boada and Santos Mañes and Michael T. Heneka and Francisco Javier Vitorica and Alfredo Ramirez and José Luis Venero and Agustín Ruiz},
  year = {2026},
  doi = {10.64898/2026.02.21.26346696},
  url = {https://doi.org/10.64898/2026.02.21.26346696}
}

RIS

TY  - JOUR
TI  - Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated States
AU  - Francisco Hernandez-Rasco
AU  - Rocío Ruiz
AU  - Itziar de Rojas
AU  - Raquel Puerta
AU  - Clara Garcia-Mayor
AU  - Ana María Espinosa-Oliva
AU  - Juan García-Revilla
AU  - Paula Bayon
AU  - Alberto Rivera-Ramos
AU  - Farah Real Oualit
AU  - Sebastián Jiménez
AU  - Maria Eugenia Saez
AU  - Rocío M. de Pablos
AU  - Feiyang Zhao
AU  - Claudia Olive
AU  - Pilar Sanz
AU  - Xavier Montalbán
AU  - Sergi Valero
AU  - Amanda Cano
AU  - María Victoria Fernández
AU  - Anne Marie Wells
AU  - Jose Enrique Cavazos
AU  - Sudha Seshadri
AU  - Merce Boada
AU  - Santos Mañes
AU  - Michael T. Heneka
AU  - Francisco Javier Vitorica
AU  - Alfredo Ramirez
AU  - José Luis Venero
AU  - Agustín Ruiz
PY  - 2026
DO  - 10.64898/2026.02.21.26346696
UR  - https://doi.org/10.64898/2026.02.21.26346696
ER  -

APA

Hernandez-Rasco, F., Ruiz, R., Rojas, I. D., Puerta, R., Garcia-Mayor, C., Espinosa-Oliva, A. M., García-Revilla, J., Bayon, P., Rivera-Ramos, A., Oualit, F. R., Jiménez, S., Saez, M. E., Pablos, R. M. D., Zhao, F., Olive, C., Sanz, P., Montalbán, X., Valero, S., Cano, A., Fernández, M. V., Wells, A. M., Cavazos, J. E., Seshadri, S., Boada, M., Mañes, S., Heneka, M. T., Vitorica, F. J., Ramirez, A., Venero, J. L., & Ruiz, A. (2026). Human IL-34 Deficiency Primes Microglia Toward Alzheimer’s Disease-Associated States. https://doi.org/10.64898/2026.02.21.26346696

Source records

crossref · retrieved 2026-09-27T10:13:42.793Z