Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium

Maria Pak, Youngchan Ryu, Sangyoon Bae, Alan Anticevic, Ana Daniela Costa, Anders L. Thorsen, Anouk L. van der Straten, Beatriz Couto, Benedetta Vai, Bjarne Hansen, Carles Soriano-Mas, Chiang-shan R. Li, Chris Vriend, Christine Lochner, Christopher Pittenger, Clara A. Moreau, Daniela Rodriguez-Manrique, Daniela Vecchio, Eiji Shimizu, Emily R. Stern, Emma Munoz-Moreno, Erika L. Nurmi, Fabrizio Piras, Federica Colombo, Federica Piras, Fern Jaspers-Fayer, Francesco Benedetti, Ganesan Venkatasubramanian, Goi Khia Eng, H. Blair Simpson, Hanyang Ruan, Hao Hu, Hein J.F. van Marle, Hirofumi Tomiyama, Ignacio Martinez-Zalacain, Jamie Feusner, Janardhanan C. Narayanaswamy, Je-Yeon Yun, Joao R. Sato, Jonathan Ipser, Jose C. Pariente, Jose M. Menchon, Joseph O'Neill, Jun Soo Kwon, Kathrin Koch, Kristen Hagen, Lea Backhausen, Lea Waller, Luisa Lazaro, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Maria Pico-Perez, Minah Kim, Nadza Dzinalija, Nicole Beyer, Nora C. Vetter, Patricia Gruner, Pedro Morgado, Philip R. Szeszko, Pino Alonso, Qing Zhao, Rachel Marsh, S. Evelyn Stewart, Sara Bertolin, Silvia Brem, Sophia I. Thomopoulos, Srinivas Balachander, Susanne Walitza, Tokiko Yoshida, Tomohiro Nakao, Venkataram Shivakumar, Wieke van Leeuwen, Y.C. Janardhan Reddy, Yoshinari Abe, Yoshiyuki Hirano, Youngsun Cho, Ysbrand D. van der Werf, Yuki Ikemizu, Yuki Sakai, Zhen Wang, Unknown, Paul M. Thompson, Willem Bruin, Guido van Wingen, Dan J. Stein, Odile A. van den Heuvel, Jiook Cha

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DOI
10.64898/2026.04.24.26351711
Published
2026-04-27
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Not recorded
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openRxiv
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BibTeX

@article{allodium:10.64898/2026.04.24.26351711,
  title = {Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium},
  author = {Maria Pak and Youngchan Ryu and Sangyoon Bae and Alan Anticevic and Ana Daniela Costa and Anders L. Thorsen and Anouk L. van der Straten and Beatriz Couto and Benedetta Vai and Bjarne Hansen and Carles Soriano-Mas and Chiang-shan R. Li and Chris Vriend and Christine Lochner and Christopher Pittenger and Clara A. Moreau and Daniela Rodriguez-Manrique and Daniela Vecchio and Eiji Shimizu and Emily R. Stern and Emma Munoz-Moreno and Erika L. Nurmi and Fabrizio Piras and Federica Colombo and Federica Piras and Fern Jaspers-Fayer and Francesco Benedetti and Ganesan Venkatasubramanian and Goi Khia Eng and H. Blair Simpson and Hanyang Ruan and Hao Hu and Hein J.F. van Marle and Hirofumi Tomiyama and Ignacio Martinez-Zalacain and Jamie Feusner and Janardhanan C. Narayanaswamy and Je-Yeon Yun and Joao R. Sato and Jonathan Ipser and Jose C. Pariente and Jose M. Menchon and Joseph O'Neill and Jun Soo Kwon and Kathrin Koch and Kristen Hagen and Lea Backhausen and Lea Waller and Luisa Lazaro and Marcelo C. Batistuzzo and Marcelo Q. Hoexter and Maria Pico-Perez and Minah Kim and Nadza Dzinalija and Nicole Beyer and Nora C. Vetter and Patricia Gruner and Pedro Morgado and Philip R. Szeszko and Pino Alonso and Qing Zhao and Rachel Marsh and S. Evelyn Stewart and Sara Bertolin and Silvia Brem and Sophia I. Thomopoulos and Srinivas Balachander and Susanne Walitza and Tokiko Yoshida and Tomohiro Nakao and Venkataram Shivakumar and Wieke van Leeuwen and Y.C. Janardhan Reddy and Yoshinari Abe and Yoshiyuki Hirano and Youngsun Cho and Ysbrand D. van der Werf and Yuki Ikemizu and Yuki Sakai and Zhen Wang and Unknown and Paul M. Thompson and Willem Bruin and Guido van Wingen and Dan J. Stein and Odile A. van den Heuvel and Jiook Cha},
  year = {2026},
  doi = {10.64898/2026.04.24.26351711},
  url = {https://doi.org/10.64898/2026.04.24.26351711}
}

RIS

TY  - JOUR
TI  - Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium
AU  - Maria Pak
AU  - Youngchan Ryu
AU  - Sangyoon Bae
AU  - Alan Anticevic
AU  - Ana Daniela Costa
AU  - Anders L. Thorsen
AU  - Anouk L. van der Straten
AU  - Beatriz Couto
AU  - Benedetta Vai
AU  - Bjarne Hansen
AU  - Carles Soriano-Mas
AU  - Chiang-shan R. Li
AU  - Chris Vriend
AU  - Christine Lochner
AU  - Christopher Pittenger
AU  - Clara A. Moreau
AU  - Daniela Rodriguez-Manrique
AU  - Daniela Vecchio
AU  - Eiji Shimizu
AU  - Emily R. Stern
AU  - Emma Munoz-Moreno
AU  - Erika L. Nurmi
AU  - Fabrizio Piras
AU  - Federica Colombo
AU  - Federica Piras
AU  - Fern Jaspers-Fayer
AU  - Francesco Benedetti
AU  - Ganesan Venkatasubramanian
AU  - Goi Khia Eng
AU  - H. Blair Simpson
AU  - Hanyang Ruan
AU  - Hao Hu
AU  - Hein J.F. van Marle
AU  - Hirofumi Tomiyama
AU  - Ignacio Martinez-Zalacain
AU  - Jamie Feusner
AU  - Janardhanan C. Narayanaswamy
AU  - Je-Yeon Yun
AU  - Joao R. Sato
AU  - Jonathan Ipser
AU  - Jose C. Pariente
AU  - Jose M. Menchon
AU  - Joseph O'Neill
AU  - Jun Soo Kwon
AU  - Kathrin Koch
AU  - Kristen Hagen
AU  - Lea Backhausen
AU  - Lea Waller
AU  - Luisa Lazaro
AU  - Marcelo C. Batistuzzo
AU  - Marcelo Q. Hoexter
AU  - Maria Pico-Perez
AU  - Minah Kim
AU  - Nadza Dzinalija
AU  - Nicole Beyer
AU  - Nora C. Vetter
AU  - Patricia Gruner
AU  - Pedro Morgado
AU  - Philip R. Szeszko
AU  - Pino Alonso
AU  - Qing Zhao
AU  - Rachel Marsh
AU  - S. Evelyn Stewart
AU  - Sara Bertolin
AU  - Silvia Brem
AU  - Sophia I. Thomopoulos
AU  - Srinivas Balachander
AU  - Susanne Walitza
AU  - Tokiko Yoshida
AU  - Tomohiro Nakao
AU  - Venkataram Shivakumar
AU  - Wieke van Leeuwen
AU  - Y.C. Janardhan Reddy
AU  - Yoshinari Abe
AU  - Yoshiyuki Hirano
AU  - Youngsun Cho
AU  - Ysbrand D. van der Werf
AU  - Yuki Ikemizu
AU  - Yuki Sakai
AU  - Zhen Wang
AU  - Unknown
AU  - Paul M. Thompson
AU  - Willem Bruin
AU  - Guido van Wingen
AU  - Dan J. Stein
AU  - Odile A. van den Heuvel
AU  - Jiook Cha
PY  - 2026
DO  - 10.64898/2026.04.24.26351711
UR  - https://doi.org/10.64898/2026.04.24.26351711
ER  - 

APA

Pak, M., Ryu, Y., Bae, S., Anticevic, A., Costa, A. D., Thorsen, A. L., Straten, A. L. V. D., Couto, B., Vai, B., Hansen, B., Soriano-Mas, C., Li, C. R., Vriend, C., Lochner, C., Pittenger, C., Moreau, C. A., Rodriguez-Manrique, D., Vecchio, D., Shimizu, E., Stern, E. R., Munoz-Moreno, E., Nurmi, E. L., Piras, F., Colombo, F., Piras, F., Jaspers-Fayer, F., Benedetti, F., Venkatasubramanian, G., Eng, G. K., Simpson, H. B., Ruan, H., Hu, H., Marle, H. J. V., Tomiyama, H., Martinez-Zalacain, I., Feusner, J., Narayanaswamy, J. C., Yun, J., Sato, J. R., Ipser, J., Pariente, J. C., Menchon, J. M., O'Neill, J., Kwon, J. S., Koch, K., Hagen, K., Backhausen, L., Waller, L., Lazaro, L., Batistuzzo, M. C., Hoexter, M. Q., Pico-Perez, M., Kim, M., Dzinalija, N., Beyer, N., Vetter, N. C., Gruner, P., Morgado, P., Szeszko, P. R., Alonso, P., Zhao, Q., Marsh, R., Stewart, S. E., Bertolin, S., Brem, S., Thomopoulos, S. I., Balachander, S., Walitza, S., Yoshida, T., Nakao, T., Shivakumar, V., Leeuwen, W. V., Reddy, Y. J., Abe, Y., Hirano, Y., Cho, Y., Werf, Y. D. V. D., Ikemizu, Y., Sakai, Y., Wang, Z., Unknown, Thompson, P. M., Bruin, W., Wingen, G. V., Stein, D. J., Heuvel, O. A. V. D., & Cha, J. (2026). Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium. https://doi.org/10.64898/2026.04.24.26351711

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