Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

Qian Wang, Liping Li, Lin You, Shuai Wang, Lei Han, Bingnan Wang, Liping Yao, Yesu Addepalli, Yong Lu, Ilgen Mender, Ann M Flusche, Chiho Kim, Nageswari Yarravarapu, Andrew Lemoff, Lawrence Lum, Jerry W Shay, Yonghao Yu, Chuo Chen

Open source

DOI
10.7554/elife.109052
Published
2026-11-04
Container
eLife
Publisher
eLife Sciences Publications, Ltd
Open access
unknown

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BibTeX

@article{allodium:10.7554/elife.109052,
  title = {Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer},
  author = {Qian Wang and Liping Li and Lin You and Shuai Wang and Lei Han and Bingnan Wang and Liping Yao and Yesu Addepalli and Yong Lu and Ilgen Mender and Ann M Flusche and Chiho Kim and Nageswari Yarravarapu and Andrew Lemoff and Lawrence Lum and Jerry W Shay and Yonghao Yu and Chuo Chen},
  year = {2026},
  journal = {eLife},
  doi = {10.7554/elife.109052},
  url = {https://doi.org/10.7554/elife.109052}
}

RIS

TY  - JOUR
TI  - Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer
AU  - Qian Wang
AU  - Liping Li
AU  - Lin You
AU  - Shuai Wang
AU  - Lei Han
AU  - Bingnan Wang
AU  - Liping Yao
AU  - Yesu Addepalli
AU  - Yong Lu
AU  - Ilgen Mender
AU  - Ann M Flusche
AU  - Chiho Kim
AU  - Nageswari Yarravarapu
AU  - Andrew Lemoff
AU  - Lawrence Lum
AU  - Jerry W Shay
AU  - Yonghao Yu
AU  - Chuo Chen
PY  - 2026
JO  - eLife
DO  - 10.7554/elife.109052
UR  - https://doi.org/10.7554/elife.109052
ER  - 

APA

Wang, Q., Li, L., You, L., Wang, S., Han, L., Wang, B., Yao, L., Addepalli, Y., Lu, Y., Mender, I., Flusche, A. M., Kim, C., Yarravarapu, N., Lemoff, A., Lum, L., Shay, J. W., Yu, Y., & Chen, C. (2026). Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer. eLife. https://doi.org/10.7554/elife.109052

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