T-cell and B-cell Immunology
This cluster of papers focuses on the development, function, and regulation of regulatory T cells (Tregs), particularly emphasizing the role of transcription factor Foxp3, TGF-ß induction, immune tolerance, thymic selection, memory T cells, IL-2 signaling, and their involvement in tumor immunity and immunological surveillance. The cluster also explores the implications of Tregs in autoimmunity and their potential for therapeutic interventions.
Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.
Most cited
- Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
- Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
- Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Most recent
- Identifying expanding TCR clonotypes with a longitudinal Bayesian mixture model and their associations with cancer patient prognosis, metastasis-directed therapy, and VJ gene enrichment
- Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing
- Epitope-conditioned generation of T-cell receptor β-chain CDR3 candidates using a pre-trained transformer model
- A CD40-Targeted IL-21 fusokine enables rapid generation of human IL-10⁺granzyme B⁺ regulatory B cells
- STAT3-mediated suppression of the pre-induction silencer Ets-2 in activated T helper cells
- Single-cell mapping of thymus-dependent naïve t-cell regeneration reveals CD61-associated states after hematopoietic stem cell transplantation