Fields · Physical Sciences · Computer Science · Computational Theory and Mathematics

Computational Drug Discovery Methods

This cluster of papers focuses on computational methods, virtual screening, and molecular docking techniques used in drug discovery. It covers topics such as drug target identification, pharmacokinetics, chemical properties, machine learning applications, polypharmacology, and network pharmacology.

173,520 works

Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.

Most cited

  1. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

    Oleg Trott, Arthur J. Olson · 2009 · Journal of Computational Chemistry · 38,310 citations

  2. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

    Garrett M. Morris, Ruth Huey, William Lindstrom, Michel F. Sanner · 2009 · Journal of Computational Chemistry · 25,653 citations

  3. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

    Antoine Daina, Olivier Michielin, Vincent Zoete · 2017 · Scientific Reports · 17,925 citations

  4. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

    Garrett M. Morris, David S. Goodsell, Robert S. Halliday, Ruth Huey · 1998 · Journal of Computational Chemistry · 10,922 citations

  5. Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy

    Richard A. Friesner, Jay L. Banks, Robert B. Murphy, Thomas A. Halgren · 2004 · Journal of Medicinal Chemistry · 10,116 citations

  6. DrugBank 5.0: a major update to the DrugBank database for 2018

    David S. Wishart, Yannick Djoumbou-Feunang, An Chi Guo, Elvis Lo · 2017 · Nucleic Acids Research · 8,957 citations

Most recent

  1. Hub genes in a pan-cancer co-expression network show potential for predicting drug responses

    Francisco Azuaje, Tony Kaoma, Céline Jeanty, Petr V. Nazarov · 2050 · Zenodo (CERN European Organization for Nuclear Research) · 0 citations

  2. In Silico Discovery of Porcupine Inhibitors from Indonesian Medicinal Plants for Modulating Wnt Overexpression in Embryonic Development

    Alfa Marzelino, Dona Suzana, Jonathan Oei · 2027 · Zenodo (CERN European Organization for Nuclear Research) · 0 citations

  3. In Silico Discovery of Porcupine Inhibitors from Indonesian Medicinal Plants for Modulating Wnt Overexpression in Embryonic Development

    Alfa Marzelino, Dona Suzana, Jonathan Oei · 2027 · Zenodo (CERN European Organization for Nuclear Research) · 0 citations

  4. Integrating in vitro pharmacokinetic screening and QSPR modeling for enhanced drug candidate selection

    Vladimir Dobričić · 2026 · DOAJ (DOAJ: Directory of Open Access Journals) · 0 citations

  5. AI potential in the pharmaceutical industr

    Grozdana Leshevska, Nena Smiljanovska · 2026 · DOAJ (DOAJ: Directory of Open Access Journals) · 0 citations

  6. Artificial Intelligence for Real-Time Pharmaceutical Quality Assurance

    Aleksandra Talevska Leshoska, Slavica Dinusheva, Dajana Apostolova, Amdi Alili · 2026 · DOAJ (DOAJ: Directory of Open Access Journals) · 0 citations

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