Fields · Health Sciences · Medicine · Oncology

Metal complexes synthesis and properties

This cluster of papers explores the advancements and challenges in platinum-based cancer chemotherapy, focusing on the molecular mechanisms of action, resistance, and toxicity associated with platinum drugs. It also delves into the development of new metal complexes as potential therapeutics, DNA interactions of metal compounds, and the exploration of ruthenium compounds as anticancer agents.

145,844 works

Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.

Most cited

  1. Synthesis, structure, and spectroscopic properties of copper( II ) compounds containing nitrogen–sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2′-yl)-2,6-dithiaheptane]copper( II ) perchlorate

    Anthony W. Addison, T. Nageswara Rao, J. Reedijk, Jacobus Van Rijn · 1984 · Journal of the Chemical Society Dalton Transactions · 9,408 citations

  2. Cisplatin in cancer therapy: Molecular mechanisms of action

    Shaloam Dasari, Paul Bernard Tchounwou · 2014 · European Journal of Pharmacology · 5,565 citations

  3. The resurgence of platinum-based cancer chemotherapy

    Lloyd R. Kèlland · 2007 · Nature reviews. Cancer · 4,724 citations

  4. Platinum Compounds: a New Class of Potent Antitumour Agents

    Barnett Rosenberg, Loretta Vancamp, James E. Trosko, Virginia H. Mansour · 1969 · Nature · 3,947 citations

  5. Cellular processing of platinum anticancer drugs

    Dong Wang, Stephen J. Lippard · 2005 · Nature Reviews Drug Discovery · 3,783 citations

  6. Structural variation in copper( i ) complexes with pyridylmethylamide ligands: structural analysis with a new four-coordinate geometry index, τ 4

    Lei Yang, Douglas R. Powell, Robert P. Houser · 2007 · Dalton Transactions · 3,448 citations

Most recent

  1. Half-Sandwich C^N^S Tridentate Iridium(III) Complexes Bearing Coumarin Fluorophores with Mitochondria-Targeting Ability and Activity Toward Cisplatin-Resistant Cancer Cells

    Peijie Liang, Jinyue Wang, Tianao Li, Yongbin Chen · 2026 · Journal of Molecular Structure · 0 citations

  2. Synthesis, Spectral, DFT and Molecular Docking Study of Schiff Base- L-Leucine Metal Complexes with Biological activity

    Maysam Basem Abdulsalam, Taghreed H. Al‐Noor · 2026 · Journal of Molecular Structure · 0 citations

  3. Metal–Ligand Engineering of Ru(III), Cu(II), Ni(II), and VO(II) Complexes Featuring a Homopiperazinyl Bis-Phenolate Scaffold: From Physicochemical Properties and structural elucidation to Pharmaceutical Applications

    Dalal Alhashmialameer · 2026 · Chemistry Africa · 0 citations

  4. Synthesis and cytotoxic activity studies of novel heterocyclic thiosemicarbazone compounds as anticancer agents

    Eda Güllü, Elvan Hasanoğlu Özkan, Hamit Emre Kızıl, Dılek Nartop · 2026 · Main Group Chemistry · 0 citations

  5. Synthesis of antibacterial ruthenium complexes modified with 4-chlorobiphenyl derivatives and their application in postoperative wound infection

    Ting Huang, Wenjing Lin, Q. Liu, Guangying Yu · 2026 · Journal of Chemical Research · 0 citations

  6. Template complex synthesis of octadecan-1-amine with 2- benzoylpyridine and Cu2+: structural, anticancer, DPPH, SOD and FRAP studies

    S. Vennila, K.S. Nagaraja, L. Lakshmi, V Radhakrishnan · 2026 · Next research. · 0 citations

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