Fields · Health Sciences · Medicine · Rheumatology

Osteoarthritis Treatment and Mechanisms

This cluster of papers focuses on the pathophysiology of osteoarthritis, with an emphasis on cartilage degradation, inflammation, joint mechanics, and potential therapeutic approaches such as cartilage regeneration using mesenchymal stem cells. It also covers the role of chondrocytes, matrix metalloproteinases, and synovitis in the development and progression of osteoarthritis.

125,552 works

Papers listed on taxonomy pages are the top few works per node from the OpenAlex snapshot. That list is not exhaustive and is not an endorsement. The topic map and the journal registry remain separate: there is still no authoritative topic-to-venue or topic-to-organization edge. Search is a lexical lookup, not a claim that a venue publishes a topic.

Most cited

  1. Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee

    Roy D. Altman, E. Asch, D. Blöch, Giles G. Bole · 1986 · Arthritis & Rheumatism · 6,829 citations

  2. Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation

    Mats Brittberg, Anders Lindahl, Anders Nilsson, Claes Ohlsson · 1994 · New England Journal of Medicine · 5,547 citations

  3. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II

    Reva C. Lawrence, David T. Felson, Charles G. Helmick, Lesley M. Arnold · 2007 · Arthritis & Rheumatism · 5,545 citations

  4. Osteoarthritis

    David J. Hunter, Sita Bierma‐Zeinstra · 2019 · The Lancet · 4,847 citations

  5. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

    Raveendhara R. Bannuru, Mikala C. Osani, Elizaveta E. Vaysbrot, N K Arden · 2019 · Osteoarthritis and Cartilage · 3,634 citations

  6. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

    Marita Cross, Emma Smith, Damian Hoy, Sandra Nolte · 2014 · Annals of the Rheumatic Diseases · 3,618 citations

Most recent

  1. T-cell–driven immune modulation in osteoarthritis: deciphering the hADSC–macrophage cross-talk

    Runjia Zhang, Xueqing Liu, Shibo Su, Ruijiao Tian · 2026 · Journal of Orthopaedic Surgery and Research · 0 citations

  2. Mechanistic and Translational Gaps in a Quercetin‐MSC Hydrogel for Osteoarthritis

    Xia Qu, Chunlian Li, Cheng Luo, Bo Chen · 2026 · Small · 0 citations

  3. Comparison of the Effects of Exercise Therapy and Orthokine Therapy on Pain Intensity, Joint Stiffness, and Quadriceps Muscle Strength in Middle-Aged Women with Knee Osteoarthritis

    Saeed Ilbeigi, Haniyeh Motedayyen, Mohammad Yousefi, Seyyed Naser Hosseini · 2026 · Journal of Sport Biomechanics · 0 citations

  4. Palmitic Acid Inhibits the Proliferation and Hypertrophy of Antler Chondrocytes by Disrupting Mitochondria-Associated Endoplasmic Reticulum Membrane Function

    Qiaoling Zhang, Zhanqing Yang, Xueyuan Yao, Yinfei Xing · 2026 · Antioxidants · 0 citations

  5. Restoring pre-osteoarthritis cartilage matrix integrity via Col9 mRNA halts osteoarthritis progression

    Jun Zhou, Jingrui Hu, Erica Yada, Jingxiao Zhong · 2026 · Science Advances · 0 citations

  6. Targeting SGK1 mitigates synovial fibrosis via suppressing M1 polarization to alleviate osteoarthritis

    Zhichao Yang, Wenwei Li, Yang Liu, Ming Wei · 2026 · International Immunopharmacology · 0 citations

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