MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder

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This study protocol outlines a double-blind, randomized controlled trial investigating the safety, efficacy, and cost-effectiveness of MDMA-assisted integrated exposure therapy for individuals with comorbid PTSD and alcohol use disorder. The research compares outcomes between participants receiving MDMA alongside prolonged exposure therapy versus those receiving an active control (niacin) under similar conditions. The resource details the study design, including participant randomization, dosing regimens, and specific clinical measures for PTSD and drinking behaviors.

ID
0b45c2b25f0e43d5
Source org
PubMed Central
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Published
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OA status
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DOI
10.1136/bmjopen-2025-114896
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BibTeX

@article{allodium:0b45c2b25f0e43d5,
  title = {MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder},
  journal = {PubMed Central},
  doi = {10.1136/bmjopen-2025-114896},
  url = {https://doi.org/10.1136/bmjopen-2025-114896}
}

RIS

TY  - JOUR
TI  - MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder
PB  - PubMed Central
DO  - 10.1136/bmjopen-2025-114896
UR  - https://doi.org/10.1136/bmjopen-2025-114896
ER  -

APA

MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder. (n.d.). PubMed Central. https://doi.org/10.1136/bmjopen-2025-114896

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