Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data

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This pooled analysis of individual participant data from two randomized controlled trials compares the effectiveness of cognitive behavior therapy for psychosis (CBTp), antipsychotics, and their combination in individuals with first-episode psychosis. The study evaluates outcomes including psychiatric symptoms and recovery at six months, alongside serious adverse events. Results indicate no significant difference between CBTp and antipsychotics alone, while suggesting potential benefits for the combined treatment approach.

ID
107df3de66044ec8
Source org
PubMed Central
Author
Anthony P. Morrison (Greater Manchester Mental Health NHS Foundation Trust), Melissa Pyle (Greater Manchester Mental Health NHS Foundation Trust), Heather Law (Greater Manchester Mental Health NHS Foundation Trust), Richard Emsley (King's College London), Graeme MacLennan (University of Aberdeen), Jemma Hudson (University of Aberdeen)
Published
2025-07-17
OA status
hybrid
DOI
10.1093/schbul/sbaf121
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:107df3de66044ec8,
  title = {Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data},
  author = {Anthony P. Morrison and Melissa Pyle and Heather Law and Richard Emsley and Graeme MacLennan and Jemma Hudson},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1093/schbul/sbaf121},
  url = {https://doi.org/10.1093/schbul/sbaf121}
}

RIS

TY  - JOUR
TI  - Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data
AU  - Morrison, Anthony P.
AU  - Pyle, Melissa
AU  - Law, Heather
AU  - Emsley, Richard
AU  - MacLennan, Graeme
AU  - Hudson, Jemma
PY  - 2025
PB  - PubMed Central
DO  - 10.1093/schbul/sbaf121
UR  - https://doi.org/10.1093/schbul/sbaf121
ER  -

APA

Morrison, A. P., Pyle, M., Law, H., Emsley, R., MacLennan, G., & Hudson, J. (2025). Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data. PubMed Central. https://doi.org/10.1093/schbul/sbaf121

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