Emerging Neurobiological and Therapeutic Insights into Schizophrenia: A Comprehensive Review

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This review synthesizes current neurobiological theories and international treatment guidelines for schizophrenia, highlighting shifts from dopamine-centric models to include glutamatergic and inflammatory mechanisms. It outlines consensus on pharmacological interventions, such as second-generation antipsychotics and clozapine, while emphasizing the necessity of integrated psychosocial strategies like CBT and family psychoeducation. The resource is suitable for clinicians and researchers seeking an overview of evolving precision medicine approaches and recovery-oriented care models.

ID
52f202e87cbb4bf9
Source org
PubMed Central
Author
Anamaria Oatu (Iuliu Hațieganu University of Medicine and Pharmacy), Tudor-Florentin Capatina (Titu Maiorescu University), Iulia-Cristina Mandras (Iuliu Hațieganu University of Medicine and Pharmacy), Antonia-Lucia Comsa (Iuliu Hațieganu University of Medicine and Pharmacy), Simona Trifu (Carol Davila University of Medicine and Pharmacy), Arina-Cipriana Pietreanu (Carol Davila University of Medicine and Pharmacy)
Published
2026-02-16
OA status
gold
DOI
10.3390/ijms27041906
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:52f202e87cbb4bf9,
  title = {Emerging Neurobiological and Therapeutic Insights into Schizophrenia: A Comprehensive Review},
  author = {Anamaria Oatu and Tudor-Florentin Capatina and Iulia-Cristina Mandras and Antonia-Lucia Comsa and Simona Trifu and Arina-Cipriana Pietreanu},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.3390/ijms27041906},
  url = {https://doi.org/10.3390/ijms27041906}
}

RIS

TY  - JOUR
TI  - Emerging Neurobiological and Therapeutic Insights into Schizophrenia: A Comprehensive Review
AU  - Oatu, Anamaria
AU  - Capatina, Tudor-Florentin
AU  - Mandras, Iulia-Cristina
AU  - Comsa, Antonia-Lucia
AU  - Trifu, Simona
AU  - Pietreanu, Arina-Cipriana
PY  - 2026
PB  - PubMed Central
DO  - 10.3390/ijms27041906
UR  - https://doi.org/10.3390/ijms27041906
ER  -

APA

Oatu, A., Capatina, T., Mandras, I., Comsa, A., Trifu, S., & Pietreanu, A. (2026). Emerging Neurobiological and Therapeutic Insights into Schizophrenia: A Comprehensive Review. PubMed Central. https://doi.org/10.3390/ijms27041906

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