Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD

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This randomized controlled trial examines sex differences in treatment outcomes for U.S. service members with comorbid PTSD and MDD, comparing behavioral activation-enhanced cognitive processing therapy (BA + CPT) to standard CPT. The study reports that among women, standard CPT resulted in significantly greater PTSD symptom reduction than BA + CPT at posttreatment and follow-up, whereas no significant sex differences were observed among men. These findings suggest that sex may differentially impact outcomes for CPT but not BA + CPT, potentially informing shared decision-making between patients and providers.

ID
368c72ce1f9d4bf7
Source org
PubMed Central
Author
Lisa H. Glassman (Leidos (United States)), Nicholas Otis (Leidos (United States)), Alexander C. Kline (Leidos (United States)), W. Michael Hunt (Naval Medical Center San Diego), Kristen H. Walter (Naval Health Research Center)
Published
2026-01-31
OA status
gold
DOI
10.1186/s40359-025-03878-4
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:368c72ce1f9d4bf7,
  title = {Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD},
  author = {Lisa H. Glassman and Nicholas Otis and Alexander C. Kline and W. Michael Hunt and Kristen H. Walter},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1186/s40359-025-03878-4},
  url = {https://doi.org/10.1186/s40359-025-03878-4}
}

RIS

TY  - JOUR
TI  - Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD
AU  - Glassman, Lisa H.
AU  - Otis, Nicholas
AU  - Kline, Alexander C.
AU  - Hunt, W. Michael
AU  - Walter, Kristen H.
PY  - 2026
PB  - PubMed Central
DO  - 10.1186/s40359-025-03878-4
UR  - https://doi.org/10.1186/s40359-025-03878-4
ER  -

APA

Glassman, L. H., Otis, N., Kline, A. C., Hunt, W. M., & Walter, K. H. (2026). Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD. PubMed Central. https://doi.org/10.1186/s40359-025-03878-4

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