Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders

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This narrative review examines the clinical features, neurobiological mechanisms, and genetic underpinnings of five anxiety disorders, categorizing them into fear-dominant, mixed, and anxiety-dominant groups. The authors synthesize findings from neuropsychological, brain function, and genetic studies to highlight shared risk factors and distinct treatment responses across these categories. The resource is intended for readers interested in the intersection of clinical presentation and biological mechanisms in anxiety disorders.

ID
55831198f49e48b0
Source org
PubMed Central
Author
Kazutaka Ohi (Gifu University), Daisuke Fujikane (Gifu University), Kentaro Takai (Gifu University), Ayumi Kuramitsu (Gifu University), Yukimasa Muto (Gifu University), Shunsuke Sugiyama (Gifu University), Toshiki Shioiri (Gifu University)
Published
2025-08-19
OA status
hybrid
DOI
10.1038/s41380-025-03155-1
PMID
Not recorded
PMCID
Not recorded
Citations
16

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BibTeX

@article{allodium:55831198f49e48b0,
  title = {Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders},
  author = {Kazutaka Ohi and Daisuke Fujikane and Kentaro Takai and Ayumi Kuramitsu and Yukimasa Muto and Shunsuke Sugiyama and Toshiki Shioiri},
  year = {2025},
  journal = {PubMed Central},
  doi = {10.1038/s41380-025-03155-1},
  url = {https://doi.org/10.1038/s41380-025-03155-1}
}

RIS

TY  - JOUR
TI  - Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders
AU  - Ohi, Kazutaka
AU  - Fujikane, Daisuke
AU  - Takai, Kentaro
AU  - Kuramitsu, Ayumi
AU  - Muto, Yukimasa
AU  - Sugiyama, Shunsuke
AU  - Shioiri, Toshiki
PY  - 2025
PB  - PubMed Central
DO  - 10.1038/s41380-025-03155-1
UR  - https://doi.org/10.1038/s41380-025-03155-1
ER  - 

APA

Ohi, K., Fujikane, D., Takai, K., Kuramitsu, A., Muto, Y., Sugiyama, S., & Shioiri, T. (2025). Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders. PubMed Central. https://doi.org/10.1038/s41380-025-03155-1

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