Effectiveness of guided self-help, guided internet-delivered cognitive behavioral therapy, and face-to-face cognitive behavioral therapy for depression and anxiety: protocols of four parallel randomized controlled non-inferiority trials of the Finnish First-Line Therapies –Initiative (FLT-Step)

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This paper outlines the protocols for four parallel randomized controlled trials within the Finnish First-Line Therapies Initiative, comparing guided self-help, guided internet-delivered CBT, and face-to-face CBT for depression and anxiety. The study aims to evaluate the effectiveness and cost-effectiveness of these interventions in a stepped care model using non-inferiority margins based on patient-detectable improvement. It includes plans for recruiting adults with specific symptom thresholds and examining the impact of waiting times on treatment outcomes.

ID
61ffcdc238984ead
Source org
PubMed Central
Author
Eeva-Eerika Helminen (University of Helsinki), Suoma Saarni (Tampere University), Kasperi Mikkonen (University of Helsinki), M. Katariina Mattila (Helsinki University Hospital), Tom Rosenström (University of Helsinki), Max Karukivi (University of Turku), Erkki Isometsä (University of Helsinki), Jan‐Henry Stenberg (Helsinki University Hospital), Jesper Ekelund (Helsinki University Hospital), Samuli I. Saarni (Tampere University)
Published
2026-03-11
OA status
gold
DOI
10.1186/s12888-026-07962-w
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:61ffcdc238984ead,
  title = {Effectiveness of guided self-help, guided internet-delivered cognitive behavioral therapy, and face-to-face cognitive behavioral therapy for depression and anxiety: protocols of four parallel randomized controlled non-inferiority trials of the Finnish First-Line Therapies –Initiative (FLT-Step)},
  author = {Eeva-Eerika Helminen and Suoma Saarni and Kasperi Mikkonen and M. Katariina Mattila and Tom Rosenström and Max Karukivi and Erkki Isometsä and Jan‐Henry Stenberg and Jesper Ekelund and Samuli I. Saarni},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1186/s12888-026-07962-w},
  url = {https://doi.org/10.1186/s12888-026-07962-w}
}

RIS

TY  - JOUR
TI  - Effectiveness of guided self-help, guided internet-delivered cognitive behavioral therapy, and face-to-face cognitive behavioral therapy for depression and anxiety: protocols of four parallel randomized controlled non-inferiority trials of the Finnish First-Line Therapies –Initiative (FLT-Step)
AU  - Helminen, Eeva-Eerika
AU  - Saarni, Suoma
AU  - Mikkonen, Kasperi
AU  - Mattila, M. Katariina
AU  - Rosenström, Tom
AU  - Karukivi, Max
AU  - Isometsä, Erkki
AU  - Stenberg, Jan‐Henry
AU  - Ekelund, Jesper
AU  - Saarni, Samuli I.
PY  - 2026
PB  - PubMed Central
DO  - 10.1186/s12888-026-07962-w
UR  - https://doi.org/10.1186/s12888-026-07962-w
ER  -

APA

Helminen, E., Saarni, S., Mikkonen, K., Mattila, M. K., Rosenström, T., Karukivi, M., Isometsä, E., Stenberg, J., Ekelund, J., & Saarni, S. I. (2026). Effectiveness of guided self-help, guided internet-delivered cognitive behavioral therapy, and face-to-face cognitive behavioral therapy for depression and anxiety: protocols of four parallel randomized controlled non-inferiority trials of the Finnish First-Line Therapies –Initiative (FLT-Step). PubMed Central. https://doi.org/10.1186/s12888-026-07962-w

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