Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial

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This randomized controlled trial investigates neural biomarkers of negative self-referential bias in remitted depressed outpatients undergoing Mindfulness-Based Cognitive Therapy or Cognitive Behavior Therapy. The study uses fMRI data to examine how pre- and post-treatment brain activity predicts depressive symptoms and relapse over a two-year period. It identifies specific patterns of prefrontal activation and somatosensory deactivation as indicators of relapse vulnerability.

ID
65dd18fa237748b4
Source org
PubMed Central
Author
Liliana C. Wu (Research Canada), Jordan Livingston (University of Toronto), Zindel V. Segal (University of Toronto), Norman A. S. Farb (University of Toronto)
Published
2026-01-01
OA status
gold
DOI
10.1016/j.nicl.2026.104025
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:65dd18fa237748b4,
  title = {Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial},
  author = {Liliana  C. Wu and Jordan Livingston and Zindel V. Segal and Norman A. S. Farb},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1016/j.nicl.2026.104025},
  url = {https://doi.org/10.1016/j.nicl.2026.104025}
}

RIS

TY  - JOUR
TI  - Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial
AU  - Wu, Liliana C.
AU  - Livingston, Jordan
AU  - Segal, Zindel V.
AU  - Farb, Norman A. S.
PY  - 2026
PB  - PubMed Central
DO  - 10.1016/j.nicl.2026.104025
UR  - https://doi.org/10.1016/j.nicl.2026.104025
ER  -

APA

Wu, L. C., Livingston, J., Segal, Z. V., & Farb, N. A. S. (2026). Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial. PubMed Central. https://doi.org/10.1016/j.nicl.2026.104025

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