Increased brain-derived neurotrophic factor following successful psychological treatment in generalized anxiety disorder: a randomized clinical trial

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This randomized clinical trial examines changes in plasma brain-derived neurotrophic factor (BDNF) levels among patients with generalized anxiety disorder undergoing either group acceptance-based behavior therapy or supportive therapy over a 14-week period. The study measures BDNF concentrations before and after treatment to assess potential biological correlates of psychological intervention. Results indicate that BDNF levels increased significantly in both treatment groups, although no correlation was found between these changes and reductions in anxiety symptom severity.

ID
6d7c5352c3314fc6
Source org
PubMed Central
Author
Lucas Marques Gandarela (Faculdade São Lucas), Thiago P. de A. Sampaio (Universidade de São Paulo), Lia Marçal (Universidade de São Paulo), Emmanuel A. Burdmann (Universidade de São Paulo), Francisco Lotufo Neto (Universidade de São Paulo), Márcio Bernik (Universidade de São Paulo)
Published
2026-04-07
OA status
gold
DOI
10.1186/s12888-026-08027-8
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:6d7c5352c3314fc6,
  title = {Increased brain-derived neurotrophic factor following successful psychological treatment in generalized anxiety disorder: a randomized clinical trial},
  author = {Lucas Marques Gandarela and Thiago P. de A. Sampaio and Lia Marçal and Emmanuel A. Burdmann and Francisco Lotufo Neto and Márcio Bernik},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1186/s12888-026-08027-8},
  url = {https://doi.org/10.1186/s12888-026-08027-8}
}

RIS

TY  - JOUR
TI  - Increased brain-derived neurotrophic factor following successful psychological treatment in generalized anxiety disorder: a randomized clinical trial
AU  - Gandarela, Lucas Marques
AU  - Sampaio, Thiago P. de A.
AU  - Marçal, Lia
AU  - Burdmann, Emmanuel A.
AU  - Neto, Francisco Lotufo
AU  - Bernik, Márcio
PY  - 2026
PB  - PubMed Central
DO  - 10.1186/s12888-026-08027-8
UR  - https://doi.org/10.1186/s12888-026-08027-8
ER  -

APA

Gandarela, L. M., Sampaio, T. P. D. A., Marçal, L., Burdmann, E. A., Neto, F. L., & Bernik, M. (2026). Increased brain-derived neurotrophic factor following successful psychological treatment in generalized anxiety disorder: a randomized clinical trial. PubMed Central. https://doi.org/10.1186/s12888-026-08027-8

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