Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment

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This narrative review synthesizes evidence on late-onset depression (LOD), characterizing it as a distinct clinical phenotype marked by apathy, psychomotor slowing, and cognitive impairment. The resource covers epidemiological factors, neurobiological mechanisms such as vascular and inflammatory pathways, and treatment strategies including pharmacotherapy and neuromodulation for clinicians and researchers.

ID
71970cba8b0f48fc
Source org
PubMed Central
Author
Antonio Maria D’Onofrio (Università Cattolica del Sacro Cuore), Gaspare Filippo Ferrajoli, Lodovico Maria Balzoni (Università Cattolica del Sacro Cuore), Marco Massetti (Università Cattolica del Sacro Cuore), Andrea Zanzarri (Università Cattolica del Sacro Cuore), Giuseppe Marano (Agostino Gemelli University Polyclinic), Marianna Mazza (Agostino Gemelli University Polyclinic), Alexia Koukopoulos (Link Campus University), Georgios D. Kotzalidis (Università Cattolica del Sacro Cuore), Lorenzo Moccia (Agostino Gemelli University Polyclinic), Alessio Simonetti (Baylor College of Medicine), Delfina Janiri (Università Cattolica del Sacro Cuore), Marco Di Nicola (Agostino Gemelli University Polyclinic), Gabriele Sani (Università Cattolica del Sacro Cuore), Giovanni Camardese (Agostino Gemelli University Polyclinic)
Published
2026-01-26
OA status
gold
DOI
10.3390/geriatrics11010013
PMID
Not recorded
PMCID
Not recorded
Citations
1

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BibTeX

@article{allodium:71970cba8b0f48fc,
  title = {Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment},
  author = {Antonio Maria D’Onofrio and Gaspare Filippo Ferrajoli and Lodovico Maria Balzoni and Marco Massetti and Andrea Zanzarri and Giuseppe Marano and Marianna Mazza and Alexia Koukopoulos and Georgios D. Kotzalidis and Lorenzo Moccia and Alessio Simonetti and Delfina Janiri and Marco Di Nicola and Gabriele Sani and Giovanni Camardese},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.3390/geriatrics11010013},
  url = {https://doi.org/10.3390/geriatrics11010013}
}

RIS

TY  - JOUR
TI  - Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment
AU  - D’Onofrio, Antonio Maria
AU  - Ferrajoli, Gaspare Filippo
AU  - Balzoni, Lodovico Maria
AU  - Massetti, Marco
AU  - Zanzarri, Andrea
AU  - Marano, Giuseppe
AU  - Mazza, Marianna
AU  - Koukopoulos, Alexia
AU  - Kotzalidis, Georgios D.
AU  - Moccia, Lorenzo
AU  - Simonetti, Alessio
AU  - Janiri, Delfina
AU  - Nicola, Marco Di
AU  - Sani, Gabriele
AU  - Camardese, Giovanni
PY  - 2026
PB  - PubMed Central
DO  - 10.3390/geriatrics11010013
UR  - https://doi.org/10.3390/geriatrics11010013
ER  -

APA

D’Onofrio, A. M., Ferrajoli, G. F., Balzoni, L. M., Massetti, M., Zanzarri, A., Marano, G., Mazza, M., Koukopoulos, A., Kotzalidis, G. D., Moccia, L., Simonetti, A., Janiri, D., Nicola, M. D., Sani, G., & Camardese, G. (2026). Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment. PubMed Central. https://doi.org/10.3390/geriatrics11010013

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