Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes

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This secondary analysis of the CBTlate trial examines blood-based biomarkers associated with Alzheimer’s disease and cellular senescence in 228 adults aged 60 and older undergoing Cognitive Behavioral Therapy for late-life depression. The study identifies two distinct depression trajectories and correlates them with baseline levels of neurofilament light chain and CXCL5, noting that CXCL5 helps differentiate these groups. The resource is intended for researchers or clinicians interested in the biological underpinnings of treatment response variability in older adults.

ID
c779f2206c3c4206
Source org
PubMed Central
Author
Pamela V. Martino Adami (University Hospital Cologne), Frank Jessen (German Center for Neurodegenerative Diseases), Frederic Brosseron (German Center for Neurodegenerative Diseases), Bettina H. Bewernick (University of Bonn), Katharina Domschke (University of Freiburg), Melanie Luppa (Leipzig University), Michael Wagner (University of Bonn), O. Peters (Charité - Universitätsmedizin Berlin), Lutz Frölich (Heidelberg University), Steffi Riedel-Heller (Leipzig University), Elisabeth Schramm (University of Freiburg), Alfredo Ramirez (University of Bonn), Forugh S. Dafsari (University Hospital Cologne)
Published
2026-01-01
OA status
gold
DOI
10.1192/j.eurpsy.2026.10153
PMID
Not recorded
PMCID
Not recorded
Citations
0

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BibTeX

@article{allodium:c779f2206c3c4206,
  title = {Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes},
  author = {Pamela V. Martino Adami and Frank Jessen and Frederic Brosseron and Bettina H. Bewernick and Katharina Domschke and Melanie Luppa and Michael Wagner and O. Peters and Lutz Frölich and Steffi Riedel-Heller and Elisabeth Schramm and Alfredo Ramirez and Forugh S. Dafsari},
  year = {2026},
  journal = {PubMed Central},
  doi = {10.1192/j.eurpsy.2026.10153},
  url = {https://doi.org/10.1192/j.eurpsy.2026.10153}
}

RIS

TY  - JOUR
TI  - Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes
AU  - Adami, Pamela V. Martino
AU  - Jessen, Frank
AU  - Brosseron, Frederic
AU  - Bewernick, Bettina H.
AU  - Domschke, Katharina
AU  - Luppa, Melanie
AU  - Wagner, Michael
AU  - Peters, O.
AU  - Frölich, Lutz
AU  - Riedel-Heller, Steffi
AU  - Schramm, Elisabeth
AU  - Ramirez, Alfredo
AU  - Dafsari, Forugh S.
PY  - 2026
PB  - PubMed Central
DO  - 10.1192/j.eurpsy.2026.10153
UR  - https://doi.org/10.1192/j.eurpsy.2026.10153
ER  -

APA

Adami, P. V. M., Jessen, F., Brosseron, F., Bewernick, B. H., Domschke, K., Luppa, M., Wagner, M., Peters, O., Frölich, L., Riedel-Heller, S., Schramm, E., Ramirez, A., & Dafsari, F. S. (2026). Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes. PubMed Central. https://doi.org/10.1192/j.eurpsy.2026.10153

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